Organic anion transporters OAT1 and OAT4 mediate the high affinity transport of glutarate derivatives accumulating in patients with glutaric acidurias

Pflugers Archiv European Journal of Physiology

Volumn 457, Issue 1, 2008, Pages 223-231

  Hagos, Yohannes ^a   Krick, Wolfgang ^a   Braulke, Thomas ^b   Mühlhausen, Chris ^b   Burckhardt, Gerhard ^a   Burckhardt, Birgitta C ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

NaDC3; OAT1; OAT4; Organic anion transporters; Renal excretion of glutarate derivatives; Sodium dependent dicarboxylate transporters

Indexed keywords

3 HYDROXYGLUTARATE; 4 AMINOHIPPURIC ACID; ESTRONE SULFATE; GLUTACONIC ACID; GLUTARIC ACID; GLUTARIC ACID DERIVATIVE; LEVO 2 HYDROXYGLUTARATE; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; ORGANIC ANION TRANSPORTER 4; TRITIUM; UNCLASSIFIED DRUG;

ACIDURIA; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; GLUTARIC ACIDURIA; HUMAN; HUMAN CELL; ISOTOPE LABELING; KIDNEY CLEARANCE; MEMBRANE TRANSPORT; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL;

ANIMALS; CELL LINE; DICARBOXYLIC ACID TRANSPORTERS; ESTRONE; FEMALE; GLUTARATES; HUMANS; KIDNEY; KINETICS; OOCYTES; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; P-AMINOHIPPURIC ACID; RNA, COMPLEMENTARY; SODIUM CHANNELS; SUBSTRATE SPECIFICITY; SYMPORTERS; TRANSFECTION; XENOPUS LAEVIS;

EID: 52549111946     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-008-0489-2     Document Type: Article

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