Semiparametric mixed-effects analysis of PK/PD models using differential equations

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 35, Issue 4, 2008, Pages 443-463

  Wang, Yi ^a   Eskridge, Kent M ^a   Zhang, Shunpu ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Compartmental models; Mixed effects modeling; Splines

Indexed keywords

CEFAMANDOLE; OXYBUTYNIN;

ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; CALCULATION; COMPARTMENT MODEL; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MATHEMATICAL ANALYSIS; NONLINEAR MIXED EFFECTS MODEL; NONLINEAR SYSTEM; NORMAL HUMAN; ORDINARY DIFFERENTIAL EQUATION; PARAMETER; PERFORMANCE; PHARMACOKINETICS PHARMACODYNAMICS MODEL; PLASMA CONCENTRATION-TIME CURVE; POPULATION RESEARCH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEMIPARAMETRIC MIXED EFFECTS ANALYSIS; SIMULATION;

ALGORITHMS; HUMANS; MANDELIC ACIDS; MODELS, STATISTICAL; MUSCARINIC ANTAGONISTS; NONLINEAR DYNAMICS; PHARMACOKINETICS; PHARMACOLOGY; SOFTWARE;

EID: 52549092939     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-008-9096-2     Document Type: Article

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