Erythropoietin with retrobulbar administration protects retinal ganglion cells from acute elevated intraocular pressure in rats

Journal of Ocular Pharmacology and Therapeutics

Volumn 24, Issue 5, 2008, Pages 453-459

  Zhong, Yi Sheng ^a   Liu, Xiao Hong ^a   Cheng, Yu ^a   Min, Ying Jun ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DRUG EFFECT; EYE PROTECTION; IMMUNOCYTOCHEMISTRY; INTRAOCULAR PRESSURE ABNORMALITY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; RETINA GANGLION CELL;

ACUTE DISEASE; ANIMALS; CELL SURVIVAL; ERYTHROPOIETIN, RECOMBINANT; IMMUNOHISTOCHEMISTRY; INTRAOCULAR PRESSURE; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; NEUROPROTECTIVE AGENTS; OCULAR HYPERTENSION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ERYTHROPOIETIN; RETINAL GANGLION CELLS;

EID: 52449120403     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2008.0021     Document Type: Article

References (33)

1. Genc, S., Koroglu, T.F., and Genc, K. Erythropoietin and the nervous system. Brain Res. 1000:19-31, 2004.
2. Morishita, E., Masuda, S., Nagao, M., et al. Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 6:105-116, 1997.
3. Dame, C., Bartmann, P., Wolber, E.M., et al. Erythropoietin gene expression in different areas of the developing human central nervous system. Dev. Brain Res. 125:69-74, 2000.
4. Digicaylioglu, M., Bichet, S., Marti, H.H., et al. Localization of specific erythropoietin binding sites in defined areas of the mouse brain. Proc. Natl. Acad. Sci. USA. 92:3717-3720, 1995.
5. Bernaudin, M., Bellail, A., Marti, H.H., et al. Neurons and astrocytes express Epo mRNA: Oxygen-sensing mechanisms that involve the redox state of the brain. Glia 30:271-278, 2000.
6. Liu R, Suzuki A, Guo Z, Mizuno Y, Urabe T. Intrinsic and extrinsic erythropoietin enhances neuroprotection against ischemia and reperfusion injury in vitro. J. Neurochem. 96:1101-1110, 2006.
7. Siren, A.L., Fratelli, M., Brines, M., et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc. Natl. Acad. Sci. U.S.A. 98:4044-4049, 2001.
8. Bernaudin, M., Marti, H.H., Roussel, S., et al. A potential role for erythropoietin in focal permanent cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 19:643-651, 1999.
9. Sakanaka, M., Wen, T.C., Matsuda, S., et al. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc. Natl. Acad. Sci. U.S.A. 95:4635-4640, 1998.
10. Brines, M.L., Ghezzi, P., Keenan, S., et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc. Natl. Acad. Sci. U.S.A.. 97:10526-10531, 2000.
11. Calapai, G., Marciano, M.C., Corica, F., et al. Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation. Eur. J. Pharmacol. 401:349-356, 2000.
12. Masuda, S., Nagao, M., and Sasaki, R. Erythropoietic, neurotrophic, and angiogenic functions of erythropoietin and regulation of erythropoietin production. [review]. Int. J. Hematol. 70:1-6, 1999.
13. Grimm, C., Wenzel, A., Groszer, M., et al. HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat. Med. 8:718-724, 2002.
14. Junk, A.K., Mammis, A., Savitz, S.I., et al. Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury. Proc. Natl. Acad. Sci. U.S.A.. 99:10659-10664, 2002.
15. Tsai, J.C., Wu, L., Worgul, B., et al. Intravitreal administration of erythropoietin and preservation of retinal ganglion cells in an experimental rat model of glaucoma. Curr. Eye Res. 30:1025-1031, 2005.
16. Kilic, Ü., Kilic, E., Soliz, J., et al. Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2. FASEB J. 19:249-251, 2005.
17. Heeschen, C., Aicher, A., Lehmann, R., et al. Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization. Blood 102:1340-1346, 2003.
18. Jaquet, K., Krause, K., Tawakol-Khodai, M., et al. Erythropoietin and VEGF exhibit equal angiogenic potential. Microvasc Res. 64:326-333, 2002.
19. Wen, T.C., Sadamoto, Y., Tanaka, J., et al. Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by upregulating Bcl-xL expression. J. Neurosci. Res. 67:795-803, 2002.
20. Klocker, N., Kermer, P., Weishaupt, J.H., et al. Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3′- kinase/protein kinase B signaling. J. Neurosci. 20:6962-6967, 2000.
21. Digicaylioglu, M., and Lipton, S.A. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signaling cascades. Nature 412:641-647, 2001.
22. Ekshyyan, O., and Aw, T.Y. Apoptosis in acute and chronic neurological disorders. Front Biosci. 9:1567-1576, 2004.
23. Maiese, K., and Chong, Z.Z. Insights into oxidative stress and potential novel therapeutic targets for Alzheimer's disease. Restor. Neurol. Neurosci. 22:87-104, 2004.
24. Kang, J.Q., Chong, Z.Z., and Maiese, K. Akt1 protects against inflammatory microglial activation through maintenance of membrane asymmetry and modulation of cysteine protease activity. J. Neurosci. Res. 74:37-51, 2003.
25. Kang, J.Q., Chong, Z.Z., and Maiese, K. Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation. Mol. Pharmacol. 64:557-569, 2003.
26. Grasso, G., Buemi, M., Alafaci, C., et al. Beneficial effects of systemic administration of recombinant human erythropoietin in rabbits subjected to subarachnoid hemorrhage. Proc. Natl. Acad. Sci. U.S.A. 99:5627-5631, 2002.
27. Martínez-Estrada, O.M., Rodríguez-Millán, E., González-De Vicente, E., et al. Erythropoietin protects the in vitro blood-brain barrier against VEGF-induced permeability. Eur. J. Neurosci. 18:2538-2544, 2003.
28. Chong, Z.Z., Kang, J.Q., and Maiese, K. Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation 106:2973-2979, 2002.
29. Chong, Z.Z., Kang, J.Q., and Maiese, K. Angiogenesis and plasticity: Role of erythropoietin in vascular systems. J. Hematother. Stem Cell Res. 11:863-871, 2002.
30. Chong, Z.Z., Kang, J.Q., and Maiese, K. Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin. J. Cereb. Blood Flow Metab. 23:320-330, 2003.
31. Heidbreder, M., Fröhlich, F., Jöhren, O., et al. Hypoxia rapidly activates HIF-3alpha mRNA expression. FASEB J. 17:1541-1543, 2003.
32. Cheung, W.K., Goon, B.L., Guilfoyle, M.C., et al. Pharmacokinetics and pharmacodynamics of recombinant human erythropoietin after single and multiple subcutaneous doses to healthy subjects. Clin. Pharmacol. Ther. 64:412-423, 1998.
33. Ehrenreich, H., Hasselblatt, M., Dembowski, C., et al. Erythropoietin therapy for acute stroke is both safe and beneficial. Mol. Med. 8:495-505, 2002.