Negative regulation of AβPP gene expression by Pur-alpha

Journal of Alzheimer's Disease

Volumn 15, Issue 1, 2008, Pages 71-82

  Darbinian, Nune ^a   Cui, Jianqi ^a   Basile, Anna ^a   Valle, Luis Del ^a   Otte, Jessica ^a   Miklossy, Judith ^b   Sawaya, Bassel E ^a   Amini, Shohreh ^a   Khalili, Kamel ^a   Gordon, Jennifer ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Alzheimer's disease; Mouse model; Pur alpha; Transcription

Indexed keywords

AMYLOID PRECURSOR PROTEIN; NUCLEIC ACID BINDING PROTEIN; PROTEIN PUR ALPHA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; PRIMER DNA; PURA PROTEIN, HUMAN; SINGLE STRANDED DNA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE SEQUENCE; GLIA CELL; HELA CELL; HUMAN; HUMAN CELL; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; RAT; ALZHEIMER DISEASE; ANIMAL; CELL DIFFERENTIATION; GENETICS; GLIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOUSE; NERVE CELL; PATHOLOGY; PLASMID; TRANSACTIVATION; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; NEUROGLIA; NEURONS; PLASMIDS; RNA, SMALL INTERFERING; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 52449118027     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2008-15106     Document Type: Article

References (29)

1. B. Anliker and U. Muller, The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins, Neurodegener Dis 3 (2006), 239-246.
2. A.D. Bergemann and E.M. Johnson, The HeLa Pur factor binds single-stranded DNA at a specific element conserved in gene flanking regions and origins of DNA replication, Mol Cell Biol 12 (1992), 1257-1265.
3. A.D. Bergemann, Z.W. Ma and E.M. Johnson, Sequence of cDNA comprising the human pur gene and sequence-specific single stranded-DNA-binding properties of the encoded protein, Mol Cell Biol 12 (1992), 5673-5682.
4. N. Darbinian, G.L. Gallia, M. Kundu, N. Shcherbik, A. Tretiakova, A. Giordano and K. Khalili, Association of Pur alpha and E2F-1 suppresses transcriptional activity of E2F-1, Oncogene 18 (1999), 6398-6402.
5. N. Darbinian, M.K. White and K. Khalili, Regulation of the Pur-alpha promoter by E2F-1, J Cell Biochem 99 (2006), 1052-1063.
6. G.L. Gallia, N. Darbinian, E.M. Johnson and K. Khalili, Self-association of Puralpha is mediated by RNA, J Cell Biochem 74 (1999), 334-348.
7. G.L. Gallia, E.M. Johnson and K. Khalili, Purα: a multifunctional single-stranded DNA and RNA-binding protein, Nucl Acids Res 28 (2000), 3197-3205.
8. F.L. Graham and A.J. van der Eb, A new technique for the assay of infectivity of human adenovirus 5 DNA, Virology 52 (1973), 456-467.
9. S. Haas, J. Gordon and K. Khalili, A developmentally regulated DNA-binding protein from mouse brain stimulates myelin basic protein gene expression, Mol Cell Biol 13 (1993), 3103-3112.
10. P.W. Hoffman and J.M. Chernak, The rat amyloid precursor protein promoter contains two DNA regulatory elements which influence high level gene expression, Biochem Biophys Res Commun 201 (1994), 610-617.
11. R. Izumi, T. Yamada, S. Yoshikai, H. Sasaki, M. Hattori and Y. Sakaki, Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse, Gene 112 (1992), 189-195.
12. E.M. Johnson, The Pur protein family: clues to function from recent studies on cancer and AIDS, Anticancer Res 23 (2003), 2093-2100.
13. E.M. Johnson, P.L. Chen, C.P. Krachmarov, S.M. Barr, M. Kanovsky, Z.W. Ma and W.H. Lee, Association of human Pur alpha with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Pur alpha recognition element, J Biol Chem 270 (1995), 24352-24360.
14. E.M. Johnson, Y. Kinoshita, D.B. Weinreb, M.J. Wortman, R. Simon, S. Amini, K. Khalili, B. Winckler and J. Gordon, Role of Pur-alpha in targeting mRNA to sites of translation in hippocampal neuronal dendrites, J Neurosci Res 83 (2006), 929-943.
15. K. Khalili, L. Del Valle, V. Muralidharan, N. Darbinian, J. Otte, E. Meier, E.M. Johnson, D.C. Daniel, S. Amini and J. Gordon, Pur-alpha is essential for postnatal brain development and developmentally-coupled cellular proliferation as revealed by genetic inactivation in the mouse, Mol Cell Biol 23 (2003), 6857-6875.
16. T. Kong, M. Scully, C.S. Shelley and S.P. Colgan, Identification of Pur alpha as a new hypoxia response factor responsible for coordinated induction of the beta 2 integrin family, J Immunol 179 (2007), 1934-1941.
17. G. La Fauci, D.K. Lahiri, S.R. Salton and N.K. Robakis, Characterization of the 5'-end region of the first two exons of the beta-protein precursor gene, Biochem Biophys Res Commun 159 (1989), 297-304.
18. D.K. Lahiri, C. Ghosh andY.W. Ge, Aproximal gene promoter region for the beta-amyloid precursor protein provides a link between development, apoptosis, and Alzheimer's disease, Ann N Y Acad Sci 1010 (2003), 643-647.
19. D.K. Lahiri and Y.-W. Ge, Role of the APP promoter in Alzheimer's disease: cell type-specific expression of the β-amyloid precursor protein, Ann N Y Acad Sci 1030 (2004), 310-316.
20. D.K. Lahiri, Y.-W. Ge and B. Maloney, Characterization of the APP proximal promoter and 5;-untranslated regions: identification of cell-type specific domains and implications in APP gene expression and Alzheimer's disease, FASEB J 19 (2005), 653-655.
21. B. Maloney, Y.-W. Ge, G.M. Alley and D.K. Lahiri, Important differences between human and mouse APOEgene promoters: limitation of mouse APOE model in studying Alzheimer's disease, J Neurochem 103 (2007), 1237-1257.
22. M.P. Mattson, Cellular actions of β-amyloid precursor protein and its soluble and fibrillogenic derivatives, Physiol Rev 77 (1997), 1081-1132.
23. S.S. Mirra and B.T. Hyman, Ageing and dementia in Greenfield's Neuropathology (Eds: D. I. Graham and P.L. Lantos). Arnold Press, London, UK, Vol 2, 200-226.
24. R.L. Neve and D.L. McPhie, Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis, Biochim Biophys Acta 1772 (2007), 430-437.
25. M. Ohta, T. Kitamoto, T. Iwaki, T. Ohgami, M. Fukui and J. Tateishi, Immunohistochemical distribution of amyloid precursor protein during normal rat development, Brain Res Dev Brain Res 75 (2003), 151-161.
26. J.T. Rogers, L.M. Leiter, J. McPhee, C.M. Cahill, S.-S. Zhan. H. Potter and L.N.G Nilsson, Translation of the Alzheimer amyloid precursor protein mRNA is upregulated by interleukin-1 through 5′-untranslated region sequences, J Biol Chem 274 (1999), 6421-6431.
27. M. Santarosa and A. Ashworth, Haploinsufficiency for tumour suppressor genes: when you don't need to go all the way, Biochim Biophys Acta 1654 (2004), 105-122.
28. C.J. Westmark and J.S. Malter, FMRP mediates mGluR5-dependent translation of amyloid precursor protein, PLOS Biol 5 (2007), e52.
29. H. Zheng, M. Jiang, M.E. Trumbauer, D.J. Sirinathsinghji, R. Hopkins, D.W. Smith, R.P. Heavens, G.R. Dawson, S. Boyce, M.W. Conner, K.A. Stevens, H.H. Slunt, S.S. Sisoda, H.Y. Chen and L.H. Van der Ploeg, beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity, Cell 81 (1995), 525-531.