Anti-inflammatory activity of the methanol extract of Moutan Cortex in LPS-activated Raw264.7 cells

Evidence-based Complementary and Alternative Medicine

Volumn 4, Issue 3, 2007, Pages 327-333

  Chun, Seung Chul ^a   Jee, Seon Young ^a   Lee, Sang Gon ^a   Park, Sook Jahr ^a   Lee, Jong Rok ^a   Kim, Sang Chan ^a  

^a Daegu Haany University   (South Korea)

Author keywords

LPS; Moutan Cortex; NF B; Nitric oxide

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PAEONIA SUFFRUTICOSA EXTRACT; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL ACTIVITY; CELL CULTURE; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG EFFECT; DRUG INHIBITION; ENZYME INHIBITION; IMMUNE RESPONSE; MOUSE; NONHUMAN; PAEONIA SUFFRUTICOSA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

EID: 52449087221     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1093/ecam/nel093     Document Type: Article

References (39)

1. Huang KC. The pharmacology of Chinese herbs. New York: CRC Press, 1999, 403-4.
2. Shon YH, Nam KS. Protective effect of moutan cortex extract on acetaminophen-induced cytotoxicity in human Chang liver cells. Biol Pharm Bull 2002;25:1427-31.
3. Shon YH, Nam KS. Protective effect of Moutan Cortex extract on acetaminophen-induced hepatotoxicity in mice. J Ethnopharmacol 2004;90:415-9.
4. Yoshikawa M, Ohta T, Kawaguchi A, Matsuda H. Bioactive constituents of Chinese natural medicines. V. Radical scavenging effect of Moutan Cortex. (1): Absolute stereostructures of two monoterpenes, paeonisuffrone and paeonisuffral. Chem Pharm Bull (Tokyo) 2000;48:1327-31.
5. Okubo T, Nagai F, Seto T, Satoh K, Ushiyama K, Kano I. The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae Radix. Biol Pharm Bull 2000;23:199-203.
6. Rho S, Chung H-S, Kang M, Lee E, Cho C, Kim H, et al. Inhibition of production of reactive oxygen species and gene expression profile by treatment of ethanol extract of Moutan cortex radicis in oxidative stressed PC12 cells. Biol Pharm Bull 2005;28:661-6.
7. Hewett JA, Roth RA. Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides. Pharmacol Rev 1993;45:382-411.
8. Watson WH, Zhao Y, Chawla RK. S-adenosylmethionine attenuates the lipopolysaccharide-induced expression of the gene for tumour necrosis factor alpha. Biochem J 1999;342:21-5.
9. Kubes P, McCafferty DM. Nitric oxide and intestinal inflammation. Am J Med 2000;109:150-8.
10. Delgado AV, McManus AT, Chambers JP. Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance P. Neuropeptides 2003;37:355-61.
11. Ahmed S, Anuntiyo J, Malemud CJ, Haqqi TM. Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: A review. Evid Based Complement Alternat Med 2005;2:301-8.
12. Miyake K. Innate recognition of lipopolysaccharide by Toll-like receptor 4-MD-2. Trends Microbiol 2004;12:186-92.
13. Kunikata T, Tatefuji T, Aga H, Iwaki K, Ikeda M, Kurimoto M. Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity. Eur J Pharmacol 2000;410:93-100.
14. Lee BG, Kim SH, Zee OP, Lee KR, Lee HY, Han JW, et al. Suppression of inducible nitric oxide synthase expression in RAW264.7 macrophages by two-carboline alkaloids extracted from Melia azedarach. Eur J Pharmacol 2000;406:301-9.
15. Seo WG, Pae HO, Oh GS, Chai KY, Kwon TO, Yun YG, et al. Inhibitory effects of methanol extract of Cyperus rotundus rhizomes on nitric oxide and superoxide production by murine macrophage cell line, RAW264.7 cells. J Ethnopharmacol 2001;76:59-64.
16. Lee YS, Han OK, Shin SW, Park JH, Kwon YK. Effects of water-extracted Cyperus Rotundus on the nitric oxide production and cytokine gene expression. Korean J Oriental Physiol Pathol 2003;17:771-6.
17. Seo WG, Pae HO, Oh GS, Chai KY, Yun YG, Kwon TO, et al. Inhibitory effect of ethyl acetate fraction from Cudrania tricuspidata on the expression of nitric oxide synthase gene in RAW264.7 macrophages stimulated with interferon-and lipopolysaccharide. Gen Pharmacol 2000;35:21-8.
18. Kim ND, Kim EM, Kang KW, Cho MK, Choi SY, Kim SG. Ginsenoside Rg3 inhibits phenylephrine-induced vascular contraction through induction of nitric oxide synthase. Br J Pharmacol 2003;140:661-70.
19. Lee AK, Sung SH, Kim YC, Kim SG. Inhibition of lipopolysaccharide- inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-κBα phosphorylation, C/EBP and AP-1 activation. Br J Pharmacol 2003;139:11-20.
20. Hwang BY, Lee JH, Jung HS, Kim KS, Nam JB, Hong YS, et al. Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB. Planta Med 2003;69:1096-101.
21. Tohda C, Nakayama N, Hatanaka F, Komatsu K. Comparison of anti-inflammatory activities of six Curcuma rhizomes: A possible curcuminoid-independent pathway mediated by curcuma phaeocaulis extract. Evid Based Complement Alternat Med 2006;2:255-60.
22. Yoon TG, Byun BH, Kwon TK, Suh SI, Byun SH, Kwon YK, et al. Inhibitory effect of Farfarae Flos water extract on COX-2, iNOS expression and Nitric Oxide production in lipopolysaccharide-activated RAW264.7 cells. Korean J Oriental Physiol Pathol 2004;18:908-13.
23. Kim SH, Kim S-A, Park M-K, Kim S-H, Park Y-D, Na H-J, et al. Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-α. Int Immunopharmacol 2004;4:279-87.
24. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, et al. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mutat Res 2001;480-481:243-68.
25. Surh YJ. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol 2002;40:1091-7.
26. Tannenbaum H, Davis P, Russell AS, Atkinson MH, Maksymowych W, Huang SH, et al. An evidence-based approach to prescribing NSAIDs in musculoskeletal disease: a Canadian consensus. Can Med Assoc J 1996;155:77-88.
27. Nozaki K, Hikiami H, Goto H, Nakagawa T, Shibahara N, Shimada Y. Keishibukuryogan (Gui-Zhi-Fu-Ling-Wan), a kampo formula, decreases disease activity and soluble vascular adhesion molecule-1 in patients with rheumatoid arthritis. Evid Based Complement Alternat Med 2006;3:359-64.
28. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from l-arginine. Nature 1988;333:664-6.
29. MacMicking J, Xie QW, Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol 1997;15:323-50.
30. Bogdan C. Nitric oxide and the immune response. Nat Immunol 2001;2:907-16.
31. Miljkovic D, Trajkovic V. Inducible nitric oxide synthase activation by interleukin-17. Cytokine Growth Factor Rev 2004;15(1):21-32.
32. Shimada Y, Yokoyama K, Goto H, Sekiya N, Mantani N, Tahara E, et al. Protective effect of keishi-bukuryo-gan and its constituent medicinal plants against nitric oxide donor-induced neuronal death in cultured cerebellar granule cells. Phytomedicine 2004;11:404-10.
33. Vane JR, Bakhle YS, Botting RM. Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 1998;38:97-120.
34. Lim BV, Lee CY, Kang JO, Kim CJ, Cho SH. Bee venom suppresses ischemia-induced increment of apoptosis and cell proliferation in hippocampal dentate gyrus. Korean J Oriental Physiol Pathol 2004;18:236-42.
35. Park WH, Lee SK, Oh HK, Bae JY, Kim CH. Tumor initiation inhibition through inhibition COX-1 activity of a traditional Korean herbal prescription, Geiji-Bokryung-Hwan, in human hepatocarcinoma cells. Immunopharmacol Immunotoxicol 2005;27:473-83.
36. Tatsumi S, Nabuchi T, Abe T, Xu L, Minami T, Ito S. Analgesic effect of extracts of Chinese medicinal herbs moutan cortex and coicis semen on neuropathic pain in mice. Neurosci Lett 2004;370:130-4.
37. Kim SH, Kim SA, Park MK, Kim SH, Park YD, Na HJ, et al. Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-α. Int Immunopharmacol 2004;4:279-87.
38. Hsieh CL, Cheng CY, Tsai TH, Lin IH, Lin CH, Chiang SY, et al. Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. J Ethnopharmacol 2006;106:208-15.
39. Ishiguro K, Ando T, Maeda O, Hasegawa M, Kadomatsu K, Ohmiya N, et al. Paeonol attenuates TNBS-induced colitis by inhibiting NF-κB and STAT1 transactivation. Toxicol Appl Pharmacol 2006;217:35-42.