Control of delayed-type hypersensitivity by ocular-induced CD8+ regulatory T cells

Chemical Immunology and Allergy

Volumn 94, Issue , 2008, Pages 138-149

  Cone, R ^a   Chattopadhyay, S ^a   O'Rourke, J ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; TRANSFORMING GROWTH FACTOR BETA;

ANTERIOR EYE CHAMBER; ANTIGEN SPECIFICITY; CD8+ T LYMPHOCYTE; CILIARY BODY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; HUMAN; IMMUNOMODULATION; IMMUNOREGULATION; INTERFERON PRODUCTION; IRIS; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; REVIEW; SPLEEN; THYMUS;

ANIMALS; ANTERIOR CHAMBER; ANTIGENS, CD8; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNE TOLERANCE; INTERFERON-GAMMA; LYMPHOTOXIN-ALPHA; MONOCYTES; NATURAL KILLER T-CELLS; NEUROIMMUNOMODULATION; NOREPINEPHRINE; RECEPTORS, NEUROPEPTIDE Y; SYMPATHETIC NERVOUS SYSTEM; T-LYMPHOCYTES, REGULATORY;

EID: 52249111369     PISSN: 16602242     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000154998     Document Type: Review

References (61)

1. Gershon RK, Kondo K: Infectious immuno logical tolerance. Immunology 1971;21:903-914.
2. Green D, Flood PM, Gershon RK: Immunoregulatory T cell pathways. Annu Rev Immunol 1983;1:439-463.
3. Jiang H, Chess L: The specific regulation of immune responses by CD8+ T cells restricted by the MHC class IB molecule, Qa-1. Annu Rev Immunol 2000;18:185-216.
4. Dorf ME, Kuchroo VK, Collins M: Suppressor T cells: some answers but more questions. Immunol Today 1992;13:241-243.
5. Shevach EM: From vanilla to 28 flavors: multiple varieties of T regulatory cells. Immunity 2006;25:195-201.
6. Sakaguchi S, Fukuma K, Kuribayashi K, Masuda T: Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J Exp Med 1985;161:72-85.
7. Jiang H, Chess L: An integrated model of immunoregulation mediated by regulatory T cell subsets. Adv Immunol 2004;83:253-288.
8. Tang XL, Smith R, Kumar V: Specific control of immunity by regulatory CD8 T cells. Cell Mol Immunol 2006;2:1-9.
9. Li X, Taylor S, Zegarelli B, Shen S, O'Rourke J, Cone RE: The induction of splenic suppressor T cells through an immune-privileged site requires an intact sympathetic nervous system. J Neuroimmunol 2004;153:40-49.
10. Niederkorn JY: Regulatory T cells and the eye. Chem Immunol Allergy 2007;92:131-139.
11. Kosiewicz MM, Streilein JW: Intraocular injection of class II-restricted peptide induces an unexpected population of CD8 regulatory cells. J Immunol 1996;157:1905-1912.
12. Li X, Wang Y, Urso D, O'Rourke J, Cone RE: Thymocytes induced by antigen injection into the anterior chamber activate splenic CD8 suppressor cells and enhance the production of IgG1 antibodies. Immunology 2004;113:44-56.
13. Ptak W, Gershon RK: Immunological agnosis: a state that derives from T suppressor cell inhibition of antigen-presenting cells Proc Natl Acad Sci USA 1982;79:2645-2648.
14. Jiang H, Ware R, Stall A, Flaherty L, Chess L, Pernis B: CD8+ T cells that specifically delete autologous CD4+ T cells expressing Vβ8 TCR: role of the Qa-1 molecule. Immunity 1995;2:185-194.
15. Faunce DE, Terajewicz A, Stein-Streilein J: In vitro generated tolerogenic APC induce CD8+ T regulatory cells that can suppress ongoing experimental autoimmune encephalomyelitis. J Immunol 2004;172:1991-1998.
16. Szczepanik M, Bryniarski K, Tutaj M, Ptak M, Skrzeczynska J, Askenase PW, Ptak W: Epicutaneous immunization induces αβ T-cell receptor CD4 CD8 double-positive non-specific suppressor T cells that inhibit contact sensitivity via transforming growth factor-β. Immunology 2005;115:42-54.
17. Wang Y, Ghali Wa-el, Pingle P, Traboulsi A, Dalal T, O'Rourke J, Cone RE: Splenic T cells from mice receiving intracameral antigen suppress in-vitro antigen-induced proliferation and interferon-γ production by sensitized lymph node cells. Ocular Immunol Inflamm 2003;11:39-52.
18. Cone RE: Soluble extracellular antigen-specific T cell immunoproteins. J Leuk Biol 1996;59:605-612.
19. Marcinkiewicz J, Bryniarski K, Ptak W: Cyclophosphamide uncovers two separate macrophage subpopulations with opposite immunogenic potential and different patterns of monokine production. Cytokine 1994;6:472-477.
20. Waldrep JC, Kaplan HJ: Anterior chamber-associated immune deviation induced by TNP-splenocytes (TNP-ACAID). II. Suppressor T-cell networks. Invest Ophthalmol Vis Sci 1983;24:1339-1345.
21. Niederkorn JY, Streilein JW: Characterization of the suppressor cell(s) responsible for anterior chamber-associated immune deviation (ACAID)-induced in BALB/c mice by P815 cells. J Immunol 1985;134:1381-1387.
22. Marchal G, Seman M, Milon G, Truffa-Bachi P, Zilberfarb V: Local adoptive transfer of skin delayed-type hypersensitivity initiated by a single T lymphocyte. J Immunol 1982;129:954-958.
23. Wilbanks GA, Streilein JW: Macrophages capable of inducing anterior chamber-associated immune deviation demonstrate spleen-seeking migratory properties. Reg Immunol 1991;4:130-137.
24. Wilbanks GA, Mammolenti M, Streilein JW: Studies on the induction of anterior chamber-associated immune deviation (ACAID). II. Eye-derived cells participate in generating blood-borne signals that induce ACAID. J Immunol 1991;146:3018-3924.
25. Wang Y, Goldschneider I, O'Rourke J, Cone RE: Blood mononuclear cells induce regulatory NK thymocytes in anterior chamber-associated immune deviation. J Leukoc Biol 2001;69:741-746.
26. Li X, Shen S, Urso D, Kalique S, Park SH, Sharafieh S, O'Rourke J, Cone RE: Phenotypic and immunoregulatory characteristics of monocytic iris cells. Immunology 2006;117:566-575.
27. Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, Kerley M, Mucenski ML, Gordon S, Stein-Streilein J: The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. J Exp Med 2005;201:1615-1625.
28. Camelo S, Voon ASP, Blunt S, McMenamin PG: Local retention of soluble antigen by potential antigen presenting cells in the anterior segment of the eye. Invest Ophthamol Vis Sci 2003;44:5315-5320.
29. Dulforce PA, Garman KL, Seitz GW, Fleischmann RI, Crespo SM, Planck SR, Parker DC, Rosenbaum JT: APCs in the anterior uveal tract do not migrate to draining lymph nodes. J Immunol 2004;172:6701-6708.
30. Cone RE, Chattopadhyay S, Sharafieh R, Li JC, O'Rourke J, Goldschneider I: Intracameral injection of antigen attracts circulating monocytic cells associated with anterior chamber-associated immune deviation to iris, blood and thymus. Association for Research in Vision and Ophthalmology, Annual Meeting, Fort Lauderdale, 2007, Abstr No 5208.
31. Hara Y, Caspi RR, Wiggert B, Dorf M, Streilein JW: Analysis of an in vitro-generated signal that induces systemic immune deviation similar to that elicited by antigen injected into the anterior chamber of the eye. J Immunol 1992;149:1531-1538.
32. D'Orazio TJ, Mayhew E, Niederkorn JY: Ocular immune privilege promoted by the presentation of peptide on tolergenic B cells in the spleen. II. Evidence for presentation by Qa-1. J Immunol 2001;166:26-32.
33. Faunce DE, Sonoda K-H, Stein-Streilein J: MIP-2 mediated recruitment of NKT cells to the spleen during tolerance induction. J Immunol 2001;166:313-321.
34. Cone RE, Li X, Sharafieh R, O'Rourke J, Vella AT: The suppression of delayed-type hypersensitivity by CD8+ regulatory T cells requires interferon-γ. Immunology 2007;120:112-119.
35. Elenkov IJ, Wilder RL, Chrousos GP, Vizi SS: The sympathetic nerve - an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000;52:595-628.
36. Li X, Taylor S, Zegarelli B, Shen S, O'Rourke J, Cone RE: The induction of splenic suppressor T cells through an immune-privileged site requires an intact sympathetic nervous system. J Neuroimmunol 2004;153:40-49.
37. Madden KS, Felten SY, Felten DF, Sundaresan PR, Livnat S: Sympathetic neural modulation of the immune system. Brain Behav Immun 1989;3:72-83.
38. Wheway J, Mackay CR, Newton RA, Sainsbury A, Boey D, Herzog H, Mackay FA: fundamental bimodal role for neuropeptide Y1 receptor in the immune system. J Exp Med 2005;202:1527-1538.
39. Campos RA, Szczepanik M, Lisbonne M, Itakura A, Leite-de-Moraes M, Askenase PW: Invariant NKT cells rapidly activated via immunization with diverse contact antigens collaborate in vitro with B-1 cells to initiate contact sensitivity. J Immunol 2006;177:3686-3694.
40. Pal E, Tabira T: Autonomic regulation of experimental autoimmune encephalomyelitis: the role of interferon-γ. Neuroimmunomodulation 2002;10:80-84.
41. Jiang X, Wang Y, Hand AR, Gillies C, Cone RE, Kirk J, O'Rourke J: Storage and release of tissue plasminogen activator by sympathetic axons in resistance vessel walls. Microvasc Res 2002;64:438-447.
42. Gomez-Duran A, Mulero-Navarro S, Chang X, Fernandez-Salguero PM: LTBP-1 blockade in dioxin receptor-null mouse embryo fibroblasts decreases TGF-β activity: role of extracellular proteases plasmin and elastase. J Cell Biochem 2006;97:380-392.
43. Jiang H, Curran S, Ruiz-Vazquez E, Liang B, Winchester R, Chess L: Regulatory CD8+ T cells fine-tune the myelin basic protein-reactive T cell receptor Vβ repertoire during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2003;100:8378-8383.
44. Tang X, Maricic I, Purohit N, Bakamjian B, Reed-Loisel LM, Beeston T, Jensen P, Kumar V: Regulation of immunity by a novel population of Qa-1-restricted CD8ααTCRαβ+>+T cells. J Immunol 2006;177:7645-7655.
45. Noble A, Zhao ZS, Cantor H: Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of Thelper 2 responses. J Immunol 1998;160:566-571.
46. Bertone S, Schiavetti F, Bellomo R, Vitale C, Ponte M, Moretta L, Mingari MC: Transforming growth factor-β-induced expression of CD94/NKG2A inhibitory receptors in human T lymphocytes. Eur J Immunol 1999;29:23.
47. Gunturi A, Berg RE, Crossley E, Murray S, Forman J: The role of TCR stimulation and TGF-β in controlling the expression of CD94/NKG2A receptors on CD8 T cells. Eur J Immunol 2005;35:766-775.
48. Cone RE, Sharafieh R, O'Rourke J, Vella AT: Intracameral antigen induces Qa-1-restricted splenic regulatory (suppressor) T cells that required interferon-γ to induce suppression. Association of Research in Vision and Ophthalmology, Annual Meeting, Fort Lauderdale, 2006, abstr 5152.
49. Chattopadhyay S, O'Rourke J, Cone RE: Implication for the CD94/NKG2A-Qa-1 system in the generation and function of ocular-induced splenic CD8+ regulatory T cells. Int Immunol 2008;20:509-516.
50. Myers L, Croft M, Kwon BS, Mittler RS, Vella AT: Peptide-specific CD8 regulatory T cells use IFN-γ to elaborate TGF-β-based suppression. J Immunol 2005;174:7625-7632.
51. Sawitzki B, Kingsley CI, Oliveira V, Karim M, Herber M, Wood KJ: IFN-γ production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J Exp Med 2005;201:1925-1935.
52. Hachem PM, Lisbonne M, Michel L, Diem S, Roongapinun S, Lefort J, Marchal G, Herbelin A, Askenase PW, Dy M, Leite-de-Moraes MC: α- Galactosylceramide-induced iNKT cells suppress experimental allergic asthma in sensitized mice: role of IFN-γ. Eur J Immunol 2005;35:2793-2802.
53. Cone RE, Li X, Sharafieh R, O'Rourke J, Vella AT: The suppression of delayed-type hypersensitivity by CD8+ regulatory T cells requires interferon-γ. Immunology 2006;120:112-119.
54. Keino H, Masli S, Sasaki S, Streilein JW, Stein-Streilein J: CD8+ T regulatory cells use a novel genetic program that includes CD103 to suppress Th1 immunity in eye-derived tolerance. Invest Ophthalmol Vis Sci 2006;47:1533-1542.
55. Wahl SM, Wen J, Moutsopoulos N: TGF-β: a mobile purveyor of immune privilege. Immunol Rev 2006;213:213-227.
56. Bickerstaff AA, Xia D, Pelletier RP, Orosz CG: Mechanisms of graft acceptance: evidence that plasminogen activator controls donor-reactive delayed-type hypersensitivity responses in cardiac allograft acceptor mice. J Immunol 2000;164:5132-5139.
57. Kezuka T, Streilein JW: In vitro generation of regulatory CD8+ T cells similar to those found in mice with anterior chamber-associated immune deviation. Invest Ophthalmol Vis Sci 2000;41:1803-1811
58. Menoret A, Myers LM, Lee S-J, Mittler RS, Rossi RJ, Vella AT: TGF-β protein processing and activity through TCR triggering of primary CD8+ T regulatory cells. J Immunol 2006;177:6091-6097.
59. Fahlen L, Read S, Gorelik L, Hurst SD, Coffman RL, Flavell RA, Powrie F: T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells. J Exp Med 2005;201:737-746.
60. Wohlfert EA, Gorelik L, Mittler R, Flavell RA, Clark RB: Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-β sensitivity in vitro and in vivo. J Immunol 2006;176:1316-1320.
61. Kapp JA, Honjo K, Kapp LM, Xu X, Cozier A, Bucy RP: TCR transgenic CD8+ T cells activated in the presence of TGF-β express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection. Int Immunol 2006;18:1549-1562.