Clofarabine in refractory Langerhans cell histiocytosis

Pediatric Blood and Cancer

Volumn 51, Issue 5, 2008, Pages 703-706

  Rodriguez Galindo, Carlos ^a   Jeng, Michael ^b   Khuu, Phuong ^b   McCarville, M Beth ^a   Jeha, Sima ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Clofarabine; LCH

Indexed keywords

CLADRIBINE; CLOFARABINE; DEOXYADENOSINE DERIVATIVE; PREDNISONE; VINBLASTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CASE REPORT; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; FEMALE; HISTIOCYTOSIS X; HUMAN; HUMAN TISSUE; LEUKEMIA; PRESCHOOL CHILD; PRIORITY JOURNAL; RELAPSE; SALVAGE THERAPY; SYSTEMIC DISEASE; TREATMENT OUTCOME; TREATMENT RESPONSE;

ADENINE NUCLEOTIDES; ANTINEOPLASTIC AGENTS; ARABINONUCLEOSIDES; CHILD, PRESCHOOL; FEMALE; HISTIOCYTOSIS, LANGERHANS-CELL; HUMANS; INFANT;

EID: 52249098576     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.21668     Document Type: Article

References (20)

1. Weitzman S, Egeler RM. Langerhans cell histiocytosis: Update for the pediatrician. Curr Opin Pediatr 2008;20:23-29.
2. Egeler RM, Annels NE, Hogendoom PC. Langerhans cell histiocytosis: a pathologic combination of oncogenesis and immune dysregulation. Pediatr Blood Cancer 2004;42:401-403.
3. Gadner H, Heiger A, Grois N, et al. Treatment strategy for disseminated Langerhans cell histiocytosis. Med Pediatr Oncol 1994;23:72-80.
4. Gadner H, Grois N, Pötschger U, et al. Improved outcome in multisystem Langerhans cell histiocytosis is associated with therapy intensification. Blood 2008;111:2556-2562.
5. Egeler RM, de Kraker J, Voûte PA. Cytosine-arabinoside, vincristine, and prednisolone in the treatment of children with disseminated Langerhans cell histiocytosis with organ dysfunction: experience at a single institution. Med Pediatr Oncol 1993;21:265-270.
6. Saven A, Burian C. Cladribine activity in adult Langerhans-cell histiocytosis. Blood 1999;93:4125-4130.
7. Rodriguez-Galindo C, Kelly P, Jeng M, et al. Treatment of children with Langerhans Cell Histiocytosis with 2-Chlorodeoxyadenosine. Am J Hematol 2002;69:179-184.
8. Weitzman S, Wayne AS, Arceci R, et al. Nucleoside analogues in the therapy of Langerhans cell histiocytosis: A survey of members of the Histiocyte Society and review of the literature. Med Pediatr Oncol 1999;33:476-481.
9. Stine KC, Saylors RL, Saccente S, et al. Efficacy of continuous infusion 2-CDA (cladribine) in pediatric patients with Langerhans cell histiocytosis. Pediatr Blood Cancer 2004;43:81-84.
10. Dhall G, Finlay JL, Dunkel IJ, et al. Analysis of outcome for patients with mass lesions of the central nervous system due to Langerhans cell histiocytosis treated with 2-chlorodeoxyadenosine. Pediatr Blood Cancer 2008;50:72-79.
11. Bernard F, Thomas C, Bertrand Y, et al. Multicentre pilot study of 2-chlorodeoxyadenosine and cytosine arabinoside combined chemotherapy in refractory Langerhans cell histiocytosis with hematological dysfunction. Eur J Cancer 2005;41:2682-2689.
12. Montgomery JA, Shortnacy-Fowler AT, Clayton SD, et al. Synthesis and biologic activity of 2.-fluoro-2-halo derivatives of 9-â-D- arabinofuranosyladenine. J Med Chem 1992;35:397-401.
13. Jeha S, Kantarjian H. Clofarabine for the treatment of acute lymphoblastic leukemia. Expert Rev Anticancer Ther 2007;7:113-118.
14. Gadner H, Grois N, Arico M, et al. A randomized trial of treatment for multisystem Langerhans' cell histiocytosis. J Pediatr 2001;138:728-734.
15. Womer RB, Anunciato KR, Chehrenama M. Oral methotrexate and alternate-day prednisone for low-risk Langerhans cell histiocytosis. Med Pediatr Oncol 1995;25:70-73.
16. Munn SE, Olliver L, Broadbent V, et al. Use of indomethacin in Langerhans cell histiocytosis. Med Pediatr Oncol 1999;32:247-249.
17. Farran RP, Zaretski E, Egeler RM. Treatment of Langerhans cell histiocytosis with Pamidronate. J Pediatr Hematol Oncol 2001;23:54-56.
18. Carrera CJ, Terai C, Lotz M, et al. Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. J Clin Invest 1990;86:1480-1488.
19. Jeha S, Gandhi V, Chan K, et al. Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia. Blood 2004;103:784-789.
20. Kantarjian HM, Gandhi V, Kozuch P, et al. Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers. J Clin Oncol 2003;21:1167-1173.