Multi-centre pilot study of 2-chlorodeoxyadenosine and cytosine arabinoside combined chemotherapy in refractory Langerhans cell histiocytosis with haematological dysfunction

European Journal of Cancer

Volumn 41, Issue 17, 2005, Pages 2682-2689

  Bernard, F ^a   Thomas, C ^b   Bertrand, Y ^c   Munzer, M ^d   Landman Parker, J ^e   Ouache, M ^f   Colin, V Minard ^f   Perel, Y ^g   Chastagner, P ^h   Vermylen, C ⁱ   Donadieu, J ^e  

^a HÔPITAL ARNAUD DE VILLENEUVE   (France)

^b HÔTEL DIEU   (France)

^c HÔPITAL DEBROUSSE   (France)

^d REIMS UNIVERSITY HOSPITAL   (France)

^e SERVICE DE DERMATOLOGIE   (France)

^f HÔPITAL NECKER ENFANTS MALADES   (France)

^g HÔPITAL PELLEGRIN   (France)

^h CHU NANCY BRABOIS   (France)

ⁱ CHU Bruxelles   (Belgium)

Author keywords

2 CdA; Ara C; Haematopoietic dysfunction; Langerhans cell histiocytosis; Pilot study; Thrombocytopaenia

Indexed keywords

ANTIEMETIC AGENT; CLADRIBINE; CLONAZEPAM; CORTICOSTEROID; COTRIMOXAZOLE; CYTARABINE; ETOPOSIDE; INFLIXIMAB; METHOTREXATE; RETINOIC ACID; THYMOCYTE ANTIBODY; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; VINBLASTINE;

ACUTE TOXICITY; ARTICLE; ASPERGILLOSIS; AUTOIMMUNE HEMOLYTIC ANEMIA; BACTERIAL INFECTION; BLOOD TOXICITY; BONE MARROW DEPRESSION; CANCER COMBINATION CHEMOTHERAPY; CANCER DIAGNOSIS; CAUSE OF DEATH; CHEMOTHERAPY INDUCED EMESIS; CHILDHOOD DISEASE; CHRONIC DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE ACTIVITY; DISEASE CONTROL; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; FEMALE; FOLLOW UP; HEMATOLOGIC DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC SYSTEM; HEMOPHAGOCYTIC SYNDROME; HISTIOCYTOSIS X; HUMAN; INFANT; INFECTION PREVENTION; LUNG ASPERGILLOSIS; MALE; MONOTHERAPY; MULTICENTER STUDY; NEUROPATHIC PAIN; NEUTROPENIA; ONSET AGE; PANCYTOPENIA; PATIENT COMPLIANCE; PILOT STUDY; PNEUMOCYSTIS PNEUMONIA; PRESCHOOL CHILD; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PURPURA; REFRACTORY LANGERHANS CELL HISTIOCYTOSIS; SALVAGE THERAPY; SEIZURE; SEPSIS; SIDE EFFECT; SPLENECTOMY; STAPHYLOCOCCUS EPIDERMIDIS; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; TREATMENT INDICATION; TREATMENT OUTCOME; VIRUS INFECTION; WORLD HEALTH ORGANIZATION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHRONIC DISEASE; CLADRIBINE; CYTARABINE; DRUG THERAPY, COMBINATION; FEMALE; HEMATOLOGIC DISEASES; HISTIOCYTOSIS, LANGERHANS-CELL; HUMANS; INFANT; INFUSIONS, INTRAVENOUS; MALE; PILOT PROJECTS; SURVIVAL ANALYSIS;

EID: 27744590986     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2005.02.007     Document Type: Article

References (40)

1. H. Gadner, N. Grois, and M. Arico A randomized trial of treatment for multisystem langerhans'cell histiocytosis J Pediatr 138 2001 728 734
2. M. Minkov, N. Grois, and A. Heitger Response to initial treatment of multisystem Langerhans cell histiocytosis: an important prognostic indicator Med Pediatr Oncol 39 2002 581 585
3. The French Langerhans' Cell Histiocytosis Study Group. A multicentre retrospective survey of Langerhans' cell histiocytosis: 348 cases observed between 1983 and 1993. Arch Dis Child 1996, 75, 17-24.
4. M. Minkov, N. Grois, and A. Heitger Treatment of multisystem Langerhans cell histiocytosis. Results of the DAL-HX 83 and DAL-HX 90 studies. DAL-HX Study Group Klin Padiatr 212 2000 139 144
5. A. Saven, and L.D. Piro 2-Chlorodeoxyadenosine: a potent antimetabolite with major activity in the treatment of indolent lymphoproliferative disorders Hematol Cell Ther 38 suppl. 2 1996 93 101
6. A. Saven, and C. Burian Cladribine activity in adult langerhans-cell histiocytosis Blood 93 1999 4125 4130
7. S. Weitzman, A.S. Wayne, and R. Arceci Nucleoside analogues in the therapy of Langerhans cell histiocytosis: a survey of members of the histiocyte society and review of the literature Med Pediatr Oncol 33 1999 476 481
8. M.A. Dimopoulos, M. Theodorakis, and E. Kostis Treatment of Langerhans cell histiocytosis with 2-chlorodeoxyadenosine Leuk Lymphoma 25 1997 187 189
9. J.D. Frost, and S.R. Wiersma Progressive Langerhans cell histiocytosis in an infant with Klinefelter syndrome successfully treated with allogeneic bone marrow transplantation J Pediatr Hematol Oncol 18 1996 396 400
10. J. Grau, J.M. Ribera, and M. Tormo Results of treatment with 2-chlorodeoxyadenosine in refractory or relapsed Langerhans cell histiocytosis. Study of 9 patients Med Clin (Barc) 116 2001 339 342
11. K.C. Stine, R.L. Saylors, and L.L. Williams 2-Chlorodeoxyadenosine (2-CDA) for the treatment of refractory or recurrent Langerhans cell histiocytosis (LCH) in pediatric patients Med Pediatr Oncol 29 1997 288 292
12. K.C. Stine, R.L. Saylors, and S. Saccente Efficacy of continuous infusion 2-CDA (cladribine) in pediatric patients with Langerhans cell histiocytosis Pediatr Blood Cancer 43 2004 81 84
13. R.M. Egeler, J. de Kraker, and P.A. Voute Cytosine-arabinoside, vincristine, and prednisolone in the treatment of children with disseminated Langerhans cell histiocytosis with organ dysfunction: experience at a single institution Med Pediatr Oncol 21 1993 265 270
14. K.R. Crews, V. Gandhi, and D.K. Srivastava Interim comparison of a continuous infusion versus a short daily infusion of cytarabine given in combination with cladribine for pediatric acute myeloid leukemia J Clin Oncol 20 2002 4217 4224
15. S.M. Kornblau, V. Gandhi, and H.M. Andreef Clinical and laboratory studies of 2-chlorodeoxyadenosine cytosine arabinoside for relapsed or refractory acute myelogenous leukemia in adults Leukemia 10 1996 1563 1569
16. S.W. Choi, B.S. Bangaru, and C.D. Wu Gastrointestinal involvement in disseminated Langerhans cell histiocytosis (LCH) with durable complete response to 2-chlorodeoxyadenosine and high-dose cytarabine J Pediatr Hematol Oncol 25 2003 503 506
17. R. Nagarajan, J. Neglia, and N. Ramsay Successful treatment of refractory Langerhans cell histiocytosis with unrelated cord blood transplantation J Pediatr Hematol Oncol 23 2001 629 632
18. Histiocyte Society Writing Group Histiocytosis syndrome in children. Lancet 1987, 15, 208-209.
19. J. Donadieu, C. Piguet, and F. Bernard A new clinical score for disease activity in Langerhans cell histiocytosis Pediatr Blood Cancer 43 2004 1 7
20. M. Schemper, and T.L. Smith A note on quantifying follow-up in studies of failure time Control Clin Trials 17 1996 343 346
21. M. Arico, R. Colella, and V. Conter Cyclosporine therapy for refractory Langerhans cell histiocytosis Med Pediatr Oncol 25 1995 12 16
22. A.M. Jakobson, A. Kreuger, and H. Hagberg Treatment of Langerhans cell histiocytosis with alpha-interferon Lancet 2 1987 1520 1521
23. F. Bertolini, W. Mingrone, and A. Alietti Thalidomide in multiple myeloma, myelodysplastic syndromes and histiocytosis. Analysis of clinical results and of surrogate angiogenesis markers Ann Oncol 12 2001 987 990
24. J.I. Henter, J. Karlen, and U. Calming Successful treatment of Langerhans'-cell histiocytosis with etanercept N Engl J Med 345 2001 1577 1578
25. G.B. McCowage, D.P. Frush, and J. Kurtzberg Successful treatment of two children with Langerhans' cell histiocytosis with 2′-deoxycoformycin J Pediatr Hematol Oncol 18 1996 154 158
26. V. Akkari, J. Donadieu, and C. Piguet Hematopoietic stem cell transplantation in patients with severe Langerhans cell histiocytosis and hematological dysfunction: experience of the French Langerhans Cell Study Group Bone Marrow Transpl 31 2003 1097 1103
27. D.C. Betticher, M.F. Fey, and A. von Rohr High incidence of infections after 2-chlorodeoxyadenosine (2-CDA) therapy in patients with malignant lymphomas and chronic and acute leukaemias Ann Oncol 5 1994 57 64
28. S.E. Chang, G.J. Koh, and J.H. Choi Widespread skin-limited adult Langerhans cell histiocytosis: long-term follow-up with good response to interferon alpha Clin Exp Dermatol 27 2002 135 137
29. S. Conias, G. Strutton, and G. Stephenson Adult cutaneous Langerhans cell histiocytosis Australas J Dermatol 39 1998 106 108
30. S. Dallafior, P. Pugin, and T. Cerny Successful treatment of a case of cutaneous Langerhans cell granulomatosis with 2-chlorodeoxyadenosine and thalidomide Hautarzt 46 1995 553 560
31. N.S. Goh, C.E. McDonald, and D.P. MacGregor Successful treatment of Langerhans cell histiocytosis with 2-chlorodeoxyadenosine Respirology 8 2003 91 94
32. F. Ottaviano, and J.L. Finlay Diabetes insipidus and Langerhans cell histiocytosis: a case report of reversibility with 2-chlorodeoxyadenosine J Pediatr Hematol Oncol 25 2003 575 577
33. A. Pardanani, R.L. Phyliky, and C.Y. Li 2-Chlorodeoxyadenosine therapy for disseminated Langerhans cell histiocytosis Mayo Clin Proc 78 2003 301 306
34. T. Robak, R. Kordek, and E. Robak Langerhans cell histiocytosis in a patient with systemic lupus erythematosus: a clonal disease responding to treatment with cladribine, and cyclophosphamide Leuk Lymphoma 43 2002 2041 2046
35. C. Rodriguez-Galindo, P. Kelly, and M. Jeng Treatment of children with Langerhans cell histiocytosis with 2-chlorodeoxyadenosine Am J Hematol 69 2002 179 184
36. A. Saven, M.L. Figueroa, and L.D. Piro 2-Chlorodeoxyadenosine to treat refractory histiocytosis X N Engl J Med 329 1993 734 735
37. A. Saven, K.A. Foon, and L.D. Piro 2-Chlorodeoxyadenosine-induced complete remissions in Langerhans-cell histiocytosis Ann Int Med 121 1994 430 432
38. J. Watts, and B. Files Langerhans cell histiocytosis: central nervous system involvement treated successfully with 2-chlorodeoxyadenosine Pediatr Hematol Oncol 18 2001 199 204
39. V. Gandhi, E. Estey, and M.J. Keating Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharmacokinetic, pharmacodynamic, and molecular interactions Blood 87 1996 256 264
40. R.C. Chasty, H. Myint, and D.G. Oscier Autoimmune haemolysis in patients with B-CLL treated with chlorodeoxyadenosine (CDA) Leuk Lymphoma 29 1998 391 398