A Randomized Trial Evaluating Different Modalities of Levosimendan Administration in Cardiac Surgery Patients With Myocardial Dysfunction

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 22, Issue 5, 2008, Pages 699-705

  De Hert, Stefan G ^a   Lorsomradee, Suraphong ^a   vanden Eede, Hervé ^a   Cromheecke, Stefanie ^a   Van der Linden, Philippe J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

cardiac bypass; cardiac surgery; levosimendan; milrinone

Indexed keywords

DOBUTAMINE; LEVOSIMENDAN; MILRINONE; NORADRENALIN; TROPONIN I;

ADULT; AGED; ANESTHESIA INDUCTION; ARTICLE; CARDIOPULMONARY BYPASS; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HEART ATRIUM FIBRILLATION; HEART EJECTION FRACTION; HEART STROKE VOLUME; HEART SURGERY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MYOCARDIAL DISEASE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL;

AGED; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; CARDIOTONIC AGENTS; FEMALE; HUMANS; HYDRAZONES; MALE; MIDDLE AGED; MILRINONE; PROSPECTIVE STUDIES; PYRIDAZINES; STROKE VOLUME; TROPONIN I;

EID: 52149102729     PISSN: 10530770     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jvca.2008.02.019     Document Type: Article

References (38)

1. Ukkonen H., Saraste M., Akkila J., et al. Myocardial efficiency during calcium sensitization with levosimendan: A noninvasive study with positron emission tomography and echocardiography in healthy volunteers. Clin Pharmacol Ther 61 (1997) 596-607
2. Lilleberg J., Nieminen M.S., Akkila J., et al. Effects of a new calcium sensitizer, levosimendan, on haemodynamics, coronary blood flow and myocardial substrate utilization early after coronary artery bypass grafting. Eur Heart J 19 (1998) 660-668
3. Ukkonen H., Saraste M., Akkila J., et al. Myocardial efficiency during levosimendan infusion in congestive heart failure. Clin Pharmacol Ther 68 (2000) 522-531
4. Toller W.G., and Stranz C. Levosimendan, a new inotropic and vasodilator agent. Anesthesiology 104 (2006) 556-569
5. + channel in rat ventricular cells. J Pharmacol Exp Ther 283 (1997) 375-383
6. Kersten J.R., Montgomery M.W., Pagel P.S., et al. Levosimendan, a new positive inotropic drug, decreases myocardial infarction size via activation of K(ATP) channels. Anesth Analg 90 (2000) 5-11
7. Yapici D., Altunkan Z., Ozeren M., et al. Effects of levosimendan on myocardial ischaemia-reperfusion injury. Eur J Anaesthesiol 25 (2008) 8-14
8. Nijhawan N., Nicolosi A.C., Montgomery M.W., et al. Levosimendan enhances cardiac performance after cardiopulmonary bypass: A prospective, randomized placebo-controlled trial. J Cardiovasc Pharmacol 34 (1999) 219-228
9. Barisin S., Husedzinovic I., Sonicki Z., et al. Levosimendan in off-pump coronary bypass: A four-times masked controlled study. J Cardiovasc Pharmacol 44 (2004) 703-708
10. Labriola C., Siro-Brigiani M., Carrata F., et al. Hemodynamic effects of levosimendan in patients with low-output heart failure after cardiac surgery. Int J Clin Pharmacol Ther 42 (2004) 204-211
11. Siirilä-Waris K., Suojaranta-Ylinen R., and Harjola V.-P. Levosimendan in cardiac surgery. J Cardiothor Vasc Anesth 19 (2005) 345-349
12. Braun J.P., Jasulaitis D., Moshirzadeh M., et al. Levosimendan may improve survival in patients requiring mechanical assist devices for post-cardiotomy heart failure. Crit Care 10 (2006) R17
13. De Luca L., Colucci W.S., Nieminen M.S., et al. Evidence-based use of levosimendan in different clinical settings. Eur Heart J 27 (2006) 1908-1920
14. Raja S.G., and Rayen B.S. Levosimendan in cardiac surgery: current best available evidence. Ann Thorac Surg 81 (2006) 1536-1546
15. De Hert S.G., Lorsomradee S., Cromheecke S., et al. The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesth Analg 104 (2007) 766-773
16. Tritapepe L., De Santis V., Vitale D., et al. Preconditioning effects of levosimendan in coronary artery bypass grafting-A pilot study. Br J Anaesth 96 (2006) 694-700
17. Van der Linden P., De Hert S., Daper A., et al. A standardized multidisciplinary approach reduces the use of allogeneic blood products in patients undergoing cardiac surgery. Can J Anaesth 48 (2001) 894-901
18. Despotis G.J., Santoro S.A., Spitznagel E., et al. Prospective evaluation and clinical utility of on-site monitoring of coagulation in patients undegoing cardiac operation. J Thorac Cardiovasc Surg 107 (1994) 271-279
19. Nashef S.A., Roques F., Michel P., et al. European system for cardiac operative risk evaluation (EuroSCORE). Eur J Cardiothor Surg 16 (1999) 9-13
20. De Hert S.G., Van der Linden P.J., Cromheecke S., et al. Choice of primary anesthetic regimen can influence intensive care unit length of stay after coronary surgery with cardiopulmonary bypass. Anesthesiology 101 (2004) 9-20
21. De Hert S.G., Van der Linden P.J., Cromheecke S., et al. Cardioprotective properties of sevoflurane in patients undergoing coronary surgery with cardiopulmonary bypass are related to the modalities of its administration. Anesthesiology 101 (2004) 299-310
22. Guarracino F., Landoni G., Tritapepe L., et al. Myocardial damage prevented by volatile anesthetics: A multicenter randomized controlled study. J Cardiothorac Vasc Anesth 20 (2006) 477-483
23. Landoni G., Biondi-Zoccai G.G., Zangrillo A., et al. Desflurane and sevoflurane in cardiac surgery: A meta-analysis of randomized clinical trials. J Cardiothorac Vasc Anesth 21 (2007) 502-511
24. Cromheecke S., Pepermans V., Hendrickx E., et al. Cardioprotective properties of sevoflurane in patients undergoing aortic valve replacement with cardiopulmonary bypass. Anesth Analg 103 (2006) 289-296
25. Landoni G., Calabrò M.G., Marchetti C., et al. Desflurane versus propofol in patients undergoing mitral valve surgery. J Cardiothorac Vasc Anesth 21 (2007) 672-677
26. Pollesello P., and Papp Z. The cardioprotective effects of levosimendan: Preclinical and clinical evidence. J Cardiovasc Pharmacol 50 (2007) 257-263
27. Tasouli A., Papadopoulos K., Antoniou T., et al. Efficacy and safety of perioperative infusion of levosminendan in patients with compromised cardiac function undergoing open-heart surgery: Importance of early use. Eur J Cardiothor Surg 32 (2007) 629-633
28. Takahashi R., Talukder M.A., and Endoh M. Effects of OR-1896, an active metabolite of levosimendan, on contractile force and aequorin light transients in intact rabbit ventricular myocardium. J Cardiovasc Pharmacol 36 (2000) 118-125
29. Takahashi R., Talukder M.A., and Endoh M. Effects of OR-1896, an active metabolite of levosimendan, on canine ventricular myocardium. Eur J Pharmacol 400 (2000) 103-112
30. Kivikko M., Lehtonen L., and Colucci W.S. Sustained hemodynamic effects of intravenous levosimendan. Circulation 107 (2003) 81-86
31. Kivikko M., Antila S., Eha J., et al. Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its metabolites during an extended infusion in patients with severe heart failure. J Clin Pharmacol 42 (2002) 43-51
32. Pagel P.S., Hettrick D.A., and Warltier D.C. Influence of levosimendan, pimobendan, and milrinone on the regional distribution of cardiac output in anaesthetized dogs. Br J Pharmacol 119 (1996) 609-615
33. Schwarte L.A., Picker O., Bornstein S.R., et al. Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs. Crit Care Med 33 (2005) 135-142
34. Morelli A., De Castro S., Teboul J.L., et al. Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Med 31 (2005) 638-644
35. Oldner A., Konrad D., Weitzberg E., et al. Effects of levosimendan, a novel inotropic calcium-sensitizing drug, in experimental septic shock. Crit Care Med 29 (2001) 2185-2193
36. Follath F., Cleland J.G., Just H., et al. Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): A randomized double-blind trial. Lancet 360 (2002) 196-202
37. Yilmaz M.B., Yalta K., Yontar C., et al. Levosimendan improves renal function in patients with acute decompensated heart failure: Comparison with dobutamine. Cardiovasc Drug Ther 21 (2007) 431-435
38. De Hert S.G., Moens M.M., Jorens P.G., et al. Comparison of two different loading doses of milrinone for weaning from cardiopulmonary bypass. J Cardiothorac Vasc Anesth 9 (1995) 264-271