Predicting the contribution of rat cytochrome P-450 3A1, 3A2 and human cytochrome P-450 3A4, 3A5 to territrem a 4beta-C hydroxylation using the relative activity factor

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 71, Issue 21, 2008, Pages 1407-1414

  Lin, Yu Husan ^a   Peng, Fu Chuo ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 3A1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBUNIT; FEMALE; HUMAN; HYDROXYLATION; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WISTAR RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; FEMALE; HUMANS; HYDROXYLATION; ISOENZYMES; MALE; MEMBRANE PROTEINS; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; PYRANS; RATS; RATS, WISTAR; SPECIES SPECIFICITY;

RATTUS; RATTUS NORVEGICUS;

EID: 52149095159     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390802240942     Document Type: Article

References (25)

1. 19 steroids by five highly purified and reconstituted rat hepatic cytochrome P450 isoenzymes J. Biol. Chem. 258:8839-8847.
2. Alvares, A. P., and Mannering, G. J. 1970. Two-substrate kinetics of drug-metabolizing enzyme systems of hepatic microsomes. Mol. Pharmacol. 6:206-212.
3. Becquemont, L., Le Bot, M. A., Riche, C., Funck-Brentano, C., Jaillon, P., and Beaune, P. 1998. Use of heterologously expressed human cytochrome P450 1A2 to predict tacrine-fluvoxamine drug interaction in man. Pharmacogenetis 8:101-108.
4. Chen, J. W., Luo, Y. L., Hwang, M. J., Peng, F. C., and Ling, K. H. 1999. Territrem B, tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. J. Biol. Chem. 274:34916-34923.
5. Crespi, C. L. 1995. Xenobiotic-metabolizing human cells as tools for pharmacological and toxicological research. Adv. Drug Res. 26:180-235.
6. Hirota, N., Ito, K., Iwatsubo, T., Green, C. E., Tyson, C. A., Shimada, N., Suzuki, H., and Sugiyama, Y. 2001. In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans. Biopharm. Drug Dispos. 22:53-71.
7. Imai, Y., Ito, R., and Sato, R. 1966. Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. J. Chem. (Tokyo) 60:417-428.
8. Ito, K., Iwatsubo, T., Kanamitsu, S., Nakajima, Y., and Sugiyama, Y. 1998. Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport. Annu. Rev. Pharmacol. Toxicol. 38:461-499.
9. Iwatsubo, T., Hirota, N., Ooie, T., Suzuki, H., Shimada, N., Chiba, K., Ishizaki, T., Green, C. E., Tyson, C. A., and Sugiyama, Y. 1997. Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data. Pharmacol. Ther. 73:147-171.
10. Kobayshi, K., Chiba, K., Yagi, T., Shimada, N., Taniguchi, T., Horie, T., Tani, M., Yamamoto, T., Ishizaki, T., and Kuroiwa, Y. 1997. Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes. J. Pharmacol. Exp.Ther. 280:927-933.
11. Kuriya, S. I., Ohmori, S., Hino, M., Ishii, I., Nakamura, H., Senda, C., Igarashi, T., Kiuchi, M., and Kitada, M. 2000. Identification od cytochrome P-450 isoform(s) responsible for the metabolism of pimbendan in human liver microsomes. Drug Metab. Dispos. 28:73-78.
12. 1 from territrem A in liver microsomes of 7-week-old female Wistar rats. J. Toxicol. Environ. Health A 66:453-467.
13. Ling, K. H., Yang, C. K., and Peng, F. T. 1979. Territrems, tremorgenic mycotoxins of Aspergillus terreus. Appl. Environ. Microbiol. 37:355-357.
14. Ling, K. H., Yang, C. K., Kuo, C. A., and Kuo, M. D. 1982. Solvent systems for improved isolation and separation of territrems A and B. Appl. Environ. Microbiol. 44:860-863.
15. Ling, K. H., Liou, H. H., Yang, C. M., and Yang, C. K. 1984. Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem C from Aspergillus terreus. Appl. Environ. Microbiol. 47:98-100.
16. Ling, K. H. 1994. Territrem, tremorgenic mycotoxins isolated from Aspergillus terreus. J. Toxicol. Toxin Rev. 13:243-252.
17. Lu, A., Wang, R., and Lin, J. 2003. Cytochrome P450 in vitro reaction phenotyping: A reevaluation of approaches used for P450 isoform identification. Drug Metab. Dispos. 31:345-350.
18. Nakajima, M., Tane, K., Nakamura, S., Shimada, N., Yamazaki, H., and Yokoi, T. 2002. Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: Effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b (5) in expression system and the differences in the marker activities. J. Pharm. Sci. 91:952-963.
19. Nerurkar, P. V., Park, S. S., Thomas, P. E., Nims, R. W., and Lubet, R. A. 1993. Methoxresorufin and benzyloxyresorufin: Substrates preferentially metabolized by cytochromes P450 1A2 and 2B, respectiviely, in the rat and mouse. Biochem. Pharmacol. 46:933-943.
20. Peng, F. C., Lin Wu, S. W., and Wang, B. L. 2001. Metabolism of TRA in liver microsomes from male Wistar rats. 1. Identification of metabolites and their metabolic pathway. J. Toxicol. Environ. Health A 64:579-593.
21. Peng, F. C., and Lin Wu, S. W. 2002. Metabolism of territrem A in liver microsomes from male Wistar rats: 3. Cytochrome P-450 isoforms catalyzing TRA metabolism. J. Toxicol. Environ. Health A 65:2163-2175.
22. Peng, F. C., Tseng, H. Y., Tasi, J. C., Lin, C., and Doehmer, J. 2003. Role of human hepatic cytochrome P-450s in territrem A metabolism. J. Toxicol. Environ. Health A 66:1237-1248.
23. Peng, F. C., Chang, C. C., Yang C. Y., Edwards, R. J., and Doehmer, J. 2006. Territrem B and C metabolism in human liver microsomes: Major role of CYP3A4 and CYP3A5. Toxicology 218:172-185.
24. Strömer, E., Von Moltke, L. L., and Greenblatt, D. J. 2000. Scaling drug biotransformation data from cDNA-expressed cytochrome P-450 to human liver: A comparison of relative activity factors and human liver abundance in studies of mirtazapine metabolism. J. Pharmacol. Exp. Ther. 295:793-810.
25. Venkatakrishnan, K., Von Moltke, L. L., and Greenblatt, D. J. 2001. Application of the relative activity factor approach in scaling from heterologously expressed cytochrome P450 to human liver microsomes: Studies on amitriptyline as a model substrate. J. Pharmacol. Exp. Ther. 297:326-337.