Metabolism of territrem a by liver microsomes of Wistar rats: Identification of the metabolites and their metabolic sequence

Journal of Toxicology and Environmental Health - Part A

Volumn 64, Issue 7, 2001, Pages 579-592

  Peng, F C ^a   Wu, S W L ^a   Wag, B L ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIHYDRO 4BETA DEMETHYLTERRITREM A; 4BETA HYDROXYMETHYL 4BETA DEMETHYLTERRITREM A; 4BETA OXO 4BETA DEMETHYLTERRITREM A; CYTOCHROME P450; HYDROXYL GROUP; METHYL GROUP; METYRAPONE; MYCOTOXIN; PYRAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPERGILLUS TERREUS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; LIVER METABOLISM; LIVER MICROSOME; MALE; MASS SPECTROMETRY; METABOLITE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; PRIORITY JOURNAL; RAT; RAT STRAIN; REACTION ANALYSIS;

ANIMALIA; ASPERGILLUS TERREUS; RATTUS NORVEGICUS;

EID: 0035824382     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/15287390152627255     Document Type: Article

References (24)

1. Mechanistic studies on C-19 demethylation in oestrogen biosynthesis
2. Mechanistic studies on aromatase and related C-C bond cleaving P-450 enzymes
3. Two substrate kinetics of drug-metabolizing enzyme systems of hepatic microsomes
4. Yeast cytochrome P-450 catalyzing lanosterol 14α-demethylation. II. Lanosterol metabolism by purified P-450 14DM and by intact microsomes
5. Study on fungi of the stored unhulled rice of Taiwan. (2) Aflatoxin B-like compounds from the culture of Aspergillus genus
6. Phenobarbital-induced increase of NADPH-cytochrome b5 reductase activity in rat liver microsomes
7. In vitro metabolism of 1,3-dioxane, 1,3-oxathiolane, and 1,3-dithiane derivatives of theophylline: A structure-metabolism correlation study
8. NMR assignments of territrem A, B, and C and the structure of MB2, the major metabolite of territrem B by rat liver microsomal fraction
9. Study on mycotoxins contaminated in food in Taiwan. (2) Tremor inducing compounds from Aspergillus terreus
10. Territrems, tremorgenic mycotoxins isolated from Aspergillus terreus
11. Intoxication possibly caused by aflatoxin Bl in the moldy rice in Shuang-Chih township
12. Territrem, tremorgenic mycotoxins of Aspergillus terreus
13. Isolation, chemical structure, acute toxicity and some physicochemical properties of territrem C from Aspergillus terreus
14. Mechanism of action of the territrem, tremorgenic mycotoxin isolated from Aspergillus terreus
15. 9 fraction from rat liver
16. Protein measurement with the Folin phenol reagent
17. Selectivity in the inhibition of mammalian cytochromes P-450 by chemical agents
18. Phenobarbital induction of procyclidine metabolism: In vitro study
19. Structure and anti-acetylcholinesterase activity of 4α-(hydroxymethyl)-4α-demethylterritrem B
20. Effect of age and phenobarbital on liver activity of mixed function oxidase
21. Effect of phenobarbital and 3-methylcholanthrene treatment on NADPH- and NADH-dependent production of reactive oxygen intermediate by rat liver nuclei
22. Microsomal enzymes of cholesterol biosynthesis: Purification of lanosterol 14α-methyl demethylation cytochrome P-450 from hepatic microsomes
23. Study of fungi of the stored unhulled rice of Taiwan. (1) Mycological survey of the stored unhulled rice
24. Yeast cytochrome P-450 catalyzing lanosterol 14α-demethylation. I. Purification and spectral properties