Effect of Indian herbal hypoglycemic agents on antioxidant capacity and trace elements content in diabetic rats

Journal of Medicinal Food

Volumn 11, Issue 3, 2008, Pages 506-512

  Chandra, Anu ^a,b   Mahdi, Abbas Ali ^a   Singh, Raj Kumar ^a   Mahdi, Farzana ^b   Chander, Ramesh ^b  

^a KING GEORGE'S MEDICAL UNIVERSITY   (India)

^b Era's Lucknow Medical College   (India)

Author keywords

Allium sativum; Antioxidant potential; Azadirachta indica; Diabetes mellitus; Herbal hypoglycemic agents; Momordica charantia; Ocimum sanctum

Indexed keywords

ANTIDIABETIC AGENT; ANTIOXIDANT; ASCORBIC ACID; AZADIRACHTA INDICA EXTRACT; CATALASE; COPPER; FERROUS ASCORBATE; GARLIC EXTRACT; GLIBENCLAMIDE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HERBACEOUS AGENT; IRON; LIPID PEROXIDE; MAGNESIUM; METAL ION; MOMORDICA CHARANTIA EXTRACT; OCIMUM SANCTUM EXTRACT; SELENIUM; SUPEROXIDE; SUPEROXIDE DISMUTASE; TRACE ELEMENT; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; COPPER BLOOD LEVEL; ENZYME ACTIVITY; ENZYME REACTIVATION; ERYTHROCYTE; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; IRON BLOOD LEVEL; LIPID PEROXIDATION; MAGNESIUM BLOOD LEVEL; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; STREPTOZOCIN DIABETES; ZINC BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; GLUTATHIONE; HYPOGLYCEMIC AGENTS; INDIA; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANTS, MEDICINAL; RATS; TRACE ELEMENTS; XANTHINE;

ALLIUM SATIVUM; AZADIRACHTA INDICA; MOMORDICA CHARANTIA; OCIMUM TENUIFLORUM; RATTUS;

EID: 52149089059     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2007.0042     Document Type: Article

References (49)

1. Davi G, Falco A, Patrono C: Lipid peroxidation in diabetes mellitus. Antioxid Redox Signal 2006;7:256-268.
2. Denneary PA: The role of oxidative stress in diabetes mellitus. Free Radic Biol Med 2006;40:1-2.
3. La Selva M, Beltramo E, Passera P, Porta M, Molinatti GM: The role of endothelium in the pathogenesis of diabetic microangiopathy. Acta Diabetol 1993;30:190-200.
4. Abbat S: Diabetes and Cardiovascular Disease Review, Issue 3: Diabetic Dyslipidemia. American Diabetes Association, Alexandria, VA, 2003, pp. 1-8. http://www.diabetes.org/uedocuments/ADACardioReview3.pdf (accessed 9 June 2008).
5. Bonnefont RD, Bastard JP, Jandon MC, Delatte J: Consequences of the diabetic status on oxidant and antioxidant balance. Diabetes Metab 2000;26:163-176.
6. Sullivan RE, Blotcky AJ, Jetton MM, Hahn HKJ, Burch RE: Serum levels of selenium, calcium, copper, magnesium, manganese and zinc in various human diseases. J Nutr 1979;109:1432-1437.
7. Walter RM Jr, Uri-Hare JY, Olin KL, Oster MH, Anawalt BD, Critchfield JW, Keen CL: Copper, zinc, magnesium status and complications of diabetes mellitus. Diabetes Care 1991;14:1050-1056.
8. Marchioli R, Schweiger C, Levantesi G, Gavazzi L, Valagussa F: Antioxidant vitamins and prevention of cardiovascular disease: epidemiological and clinical trail data. Lipids 2001;36:553-563.
9. Vanella A, Russo A, Acquavivo R, Campisi A, DiGiacoma SV, Barecellona ML: L-Propionyl carnitine as superoxide scavenger, antioxidant and DNA damage protector. Cell Biol Toxicol 2000;16:99-104.
10. Packer L, Kraemer K, Rimbach G: Molecular aspects of lipoic acid in the prevention of diabetic complications. Nutrition 2001;17:888-895.
11. Khan A, Safdar M: Role of nutrients, spices and natural products in diabetes mellitus. Pak J Nutr 2003;2:1-12.
12. Shukla R, Sharma SB, Puri D, Murthy PS: Medicinal plants for treatment of diabetes mellitus. Indian J Clin Biochem 2000;15:169-177.
13. Mahdi AA, Chandra A, Singh RK, Shukla S, Mishra LC, Ahmad S: Effect of herbal hypoglycemic agents on oxidative stress and antioxidant status in diabetic rats. Indian J Clin Biochem 2003;18:8-15.
14. Chandra A, Mahdi AA, Ahmad S, Singh RK: Indian herbal results in hypoglycemic responses in streptozotocin-induced diabetic rats. Nutr Res 2007;27:161-168.
15. Sharma MK, Khare AK, Feroz H: Effect of neem oil on blood sugar levels of normal, hyperglycemic and diabetic animals. Indian Med Gazette 1983;117:380-383.
16. Srinivasan K: Plant foods in the management of diabetes mellitus: spices as beneficial anti diabetic food adjuncts. Int J Food Sci Nutr 2005;56:399-416.
17. Hannan JMA, Marenah L, Ali L, Rokeya B, Flatt PR, Abdel-Wahab YHA: Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic β-cells. J Endocrinol 2006;189:127-136.
18. Zacharis NT, Sepastian KL, Babu Philip, Augusti KT: Hypoglycemic and hypolipidemic effects of garlic in sucrose fed rabbits. Indian J Physiol Pharmacol 1980;24:151-153.
19. Satyanarayana Murty K, Narayana Rao D, Krishna Rao D, Gopalakrishna Murty LB: A preliminary study on hypoglycaemic and antihyperglycaemic effects of Azadirachta indica. Indian J Pharmacol 1978;10:247-250.
20. Karunanayake HE, Jeevathayaparan S, Tennekoon HK: Effect of Momordica charantia fruit juice on streptozotocin induced diabetes in rats. J Ethnopharmacol 1990;30:199-204.
21. Luthy N, Ortelio M: A study of a possible oral hypoglycemic factor in Albahaca morada (O. sanctum). Ohio J Sci 1964;64:222-224.
22. Gupta RA, Dixit VP: Dose dependent alterations in lipid and carbohydrate metabolites in streptozotocin induced diabetic rats. Endocrinology 1982;80:332-340.
23. Trinder P: Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem 1969;6:24-30.
24. Xu B, Chia SE, Ong CH: Concentrations of cadmium, lead selenium and zinc in human blood and seminal plasma. Biol Trace Elem Res 1994;40:49-57.
25. Mahdi AA, Singh R, Singh RK: Role of reactive oxygen species and antioxidants in human diseases: an overview. In: Perspective in Biological Sciences (Rai V, Naik ML, Manoharacharry C, eds.). World Laser Graphics, Raipur, India, 1996, pp. 55-70.
26. Ohkawa H, Ohishi N: Reaction of linoleic acid hydroperoxide with thiobarbituric acid. J Lipid Res 1978;19:1053-1057.
27. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
28. Hazelton GA, Lang CA: GSH content of tissue in aging mouse. Biochem J 1985;188:25-30.
29. Bindoli A, Valente M, Cavallin L: Inhibition of xanthine oxidase and xanthine dehydrogenase activity. Pharmacol Res Commun 1985;17:831-839.
30. McCord JM, Fridovich J: Superoxide dismutase. An enzymic function for erythrocuprin (hemocuprin). J Biol Chem 1969;244:6049-6055.
31. Devasagayam TPA, Tarachand U: Decreased lipid peroxidation in rat kidney during gestation. Biochem Biophys Res Commun 1987;145:134-138.
32. Shibib BA, Khan LA, Rahman R: Hypoglycemic activity of Coccinia indica and Momordica charantia in diabetic rats: depression of the hepatic glycogenic enzymes glucose-6-phosphatase and fructose 1,6 bisphosphatase and elevation of both liver and red cell count enzyme glucose-6-phosphate dehydrogenase. Biochem J 1993;292:267-270.
33. Chattopadhyay RR: Hypoglycemic effect of Ocimum sanctum leaf extract in normal and streptozotocin diabetic rats. Indian J Exp Biol 1993;31:891-893.
34. Kumari K, Augusti KT: Antidiabetic effect of S-methylcysteine sulphoxide on alloxan diabetes. Planta Med 1995;61:72-76.
35. Gedik N, Kabasakal L, Sehirli O, Ercan F, Sirvanci S, Keyer-Uysal M, Sener G: Long-term administration of aqueous garlic extract (AGE) alleviates liver fibrosis and oxidative damage induced by biliary obstruction in rats. Life Sci 2005;76:2593-2606.
36. Arivazhagan S, Velmusugan B, Bhuvaneswari V, Nagini S: Effect of aqueous extract of garlic (Allium sativum) and neem (Azadirachta indica) leaf on hepatic and blood oxidant-antioxidant status during experimental gastric carcinoma. J Med Food 2004;7:334-339.
37. Saravanan R, Pari L: Antihyperlipidemic and antiperoxidative effect of diasulin, a poly herbal formulation in alloxan induced hyperglycemic rats. BMC Comp Alternative Med 2005;5:14-17.
38. Banerjee S, Prashar R, Kumar A, Rao AR: Modulatory influence of alcoholic extract of Ocimum sanctum leaves on carcinogen metabolizing enzyme activities and reduced glutathione levels in mouse. Nutr Cancer 1996;25:205-217.
39. Seshiah V: Oral antidiabetic drugs. In: A Hand Book on Diabetes Mellitus (Seshiah V, Harinarayan CV, Ganesan VS, eds.). Diabetes Education and Research Foundation, Chennai, India, 1998, pp. 43-54.
40. Griesmacher A, Kinghauser M, Andert SE, Schreiner W, Toma C, Knoebl P, Pietschmann P, Prager R, Schnack C, Schernthaner G, Mueller MM: Enhanced serum levels of thiobarbituric acid reactive substances in diabetes mellitus. Am J Med 1995;98:469-475.
41. Martin-Gallan P, Garrascosa A, Gussinye M, Dominguez C: Biomarkers of diabetes associated oxidative stress and antioxidant status in young diabetic patient with or without subclinical complications. Free Radic Biol Med 2003;34:1563-1574.
42. Lonnerdal B, Sandstrom B: Factor influencing the uptake of metal ions from the digestive tract. In: Hand Book of Metal-Ligand Interactions in Biological Fluids. Bioinorganic Medicine, Vol. 2 (Berthon G, ed.). Marcel Dekker, New York, 1995, pp. 331-337.
43. Evans JL, Goldfine ID, Maddux BA, Gordskey GM: Oxidative and stress activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 2002;23:599-622.
44. Du XL, Edelstem D, Rossetti L, Fantus IG, Goldberg H, Ziyadeh F, Wu J, Brownlee M: Hyperglycemia induced mitochondrial superoxide over production activates the hexosamine pathway and induces plasminogen activator inhibitor expression by increasing sp-1 glucosylation. Proc Natl Acad Sci U S A 2002;97:12222-12226.
45. Brodsky SV, Gao S, Li H, Goligorsky MS: Hyperglycemia switches from mitochondrial nitric oxide to superoxide production in endothelial cells. Am J Physiol Heart Circ Physiol 2002;283:H2130-H2139.
46. Jabeen R, Saleemudin M: Polyclonal antibodies inhibit the glycation-induced inactivation of bovine Cu,Zn-superoxide dismutase. Biotechnol Appl Biochem 2006;43:49-53.
47. Sreedhar B, Nair KM: Modulation of aconitase metallothionein, and oxidative stress in zinc deficient rat intestine during zinc and iron repletion. Free Radic Biol Med 2005;39:999-1008.
48. Herle UN, Gaikwad NJ: Effect of Momordica charantia and Tinospora cardiofolia extract on intestinal drug transporter pump: P-glycoprotein. Indian J Pharmacol 2004;36:312-320.
49. Upadhyay L, Mehrotra A, Srivastava AK, Rai NP, Tripathi K: An experimental study of some indigenous drugs with special reference to hydraulic permeability. Indian J Exp Biol 2001;39:1308-1310.