Nicotine aerosol generation from thermally reversible zinc halide complexes using the Staccato® system

Drug Development and Industrial Pharmacy

Volumn 34, Issue 9, 2008, Pages 936-942

  Simis, Kathleen ^a   Lei, Mingzu ^a   Lu, Amy Tsai ^a   Sharma, Krishnamohan C V ^a   Hale, Ron L ^a   Timmons, Ryan ^a   Cassella, Jim ^a  

^a Alexza Pharmaceuticals   (United States)

Author keywords

Condensation aerosol; Nicotine; Staccato; Thermally reversible; Zinc halide

Indexed keywords

NICOTINE; UNCLASSIFIED DRUG; ZINC BROMIDE; ZINC CHLORIDE; ZINC DERIVATIVE; ZINC HALIDE;

AEROSOL; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; FILM COATING; HEATING; INHALER; PARTICLE SIZE; THERMOGRAVIMETRY; VAPORIZATION;

AEROSOLS; BROMIDES; CALORIMETRY, DIFFERENTIAL SCANNING; CHLORIDES; NEBULIZERS AND VAPORIZERS; NICOTINE; THERMOGRAVIMETRY; ZINC COMPOUNDS;

EID: 52149088333     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040802149061     Document Type: Article

References (27)

1. Airoldi, C., Silva, M., & Chagas, A. P. (1986). Heterocyclic nitrogen-containing electron-pair donor ligands: A thermochemical study of adducts with zinc, cadmium, and mercury chlorides. J. Chem. Soc., Dalton Trans., 1986(9), 1913-1916.
2. Benowitz, N. L. (1996). Pharmacology of nicotine: Addiction and therapeutics. Annu. Rev. Pharmacol. Toxicol., 36(1), 597-613.
3. Benowitz, N. L., & Jacob, P. (1984). Daily intake of nicotine during cigarette smoking. Clin. Pharmacol. Ther., 35(4), 499-504.
4. de Moura, M. F. V., de Oliveira, Ó., & de Farias, R. F. (2003). Synthesis, characterization and thermogravimetric study of zinc group halides adducts with Imidazole. Thermochim. Acta., 405(2), 219-224.
5. Fagerström K. O., P. O., & Giordani Stelson, B. F. (1994). Nicotine may relieve symptoms of Parkinson's disease. Psychopharmacology (Berl), 116(1), 117-119.
6. Ferm, M. (1979). Method for determination of atmospheric ammonia. Atmos. Environ., 1967; 13(10), 1385-1393.
7. Jones, G. M. M. Sahakian, B. J. Levy, R. Warburton, D. M. & Gray, J. A. (1992). Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease. Psychopharmacology, 108(4), 485-494.
8. Hammond, D., Fong, G. T., Cummings, K. M., O'Connor, R. J., Giovino, G. A., & McNeill, A. (2006). Cigarette yields and human exposure: A comparison of alternative testing regimens. Cancer Epidemiol. Biomarkers Prev., 15(8), 1495.
9. Hinds, W. C. (1999). Aerosol technology: Properties, behavior, and measurement of airborne particles (2nd ed.). New York: Wiley.
10. Kumari, V., & Postma, P. (2005). Nicotine use in schizophrenia: The self medication hypotheses. Neurosci. Biobehav. Rev., 29(6), 1021-1034.
11. Lewis, D. A., Colbeck, I., & Mariner, D. C. (1994). Diffusion denuder method for sampling vapor-phase nicotine in mainstream tobacco smoke. Anal. Chem., 66(20), 3525-3527.
12. 2.2 L(X= Cl, Br; L= ligand with O or N as electron donor atom). Polyhedron, 13(1), 27-37.
13. Macleod, D., Spyker, D. A., Habib, A., Ho, K. Y., & Gan, T. J. (2007, October). Pharmacodynamic response to fentanyl delivered by intravenous and inhaled thermal aerosol routes. Poster session presented at the Annual Meeting of the American Society of Anesthesiologists, San Francisco, CA.
14. Macleod, D., Spyker, D. A., Houghton, W. C., Ikeda, K., & Gan, T. J. (2007, October). Pharmacokinetic profiles of fentanyl delivered by intravenous and inhaled thermal aerosol routes. Poster session presented at the Annual Meeting of the American Society of Anesthesiologists, San Francisco, CA.
15. Muralidharan, S., Udupa, M. R., & Nagaraja, K. S. (1988). Nicotine complexes of zinc(II) cadmium(II) and mercury (II). Indian J. Chem., 27A, 76-77.
16. Myers, D. J., Timmons, R. D., Lu, A. T., Hale, R. L., Solas, D. W., & Soni, P., et al. (2007). The effect of film thickness on thermal aerosol generation. Pharm. Res., 24(2), 336-342.
17. Perfetti, T. A. (1983). Structural study of nicotine salts. Beitr. Zur Tabakforsch. Int., 12(2), 43-54.
18. Perfetti, T. A., Norman, A. B., Gordon, B. M., Coleman Iii, W. M., Morgan, W. T., & Dull, G. M., et al. (2000). The transfer of nicotine from nicotine salts to mainstream smoke. Beitr. Zur Tabakforsch. Int., 19, 141-158.
19. Prochazka, A. V. (2000). New developments in smoking cessation. Am. Coll. Chest Phys., 117, 169-175.
20. Rabinowitz, J. D., Lloyd, P. M., Munzar, P., Myers, D. J., Cross, S., & Damani, R., et al. (2006). Ultra-fast absorption of amorphous pure drug aerosols via deep lung inhalation. J. Pharm. Sci. 95(11), 2438-2451.
21. Rabinowitz, J. D., Wensley, M., Lloyd, P., Myers, D., Shen, W., & Lu, A., et al. (2004). Fast onset medications through thermally generated aerosols. J. Pharmacol. Exp. Ther., 309(2), 769-775.
22. Riggs, D. M., & Perfetti, T. A. (2001). Thermochemical properties of nicotine salts. Contrib. Tob. Res., 19(6), 289-295.
23. Schneider, N. G., Olmstead, R. E., Franzon, M. A., & Lunell, E. (2001). The nicotine inhaler: Clinical pharmacokinetics and comparison with other nicotine treatments. Clin. Pharmacokinet., 40(9), 661-684.
24. Seeman, J., Fournier, J. A., Paine III, J. B., & Waymack, B. E. (1999). The form of nicotine in tobacco. Thermal transfer of nicotine and nicotine acid salts to nicotine in the gas phase. J. Agric. Food Chem., 47(12), 5133-5145.
25. Steffen, W. L., & Palenik, G. J. (1974). Dichlorobis (pyridine) zinc (II). J. Amer. Chem. Soc., 96, 1502-1507.
26. Timmons, R. D., Simis, K. S., Lei, M., Lu, A. T., Sharma, K., Hale, R., et al. (2008, May 11-15, 2008). Feasibility study of nicotine aerosol generation using the Staccato® system. Paper presented at the Respiratory Drug Delivery, Scottsdale, AZ.
27. Villafane, G., Cesaro, P., Rialland, A., Baloul, S., Azimi, S., & Bourdet, C., et al. (2007). Chronic high dose transdermal nicotine in Parkinson's disease: An open trial. Eur. J. Neurol., 14(12), 1313-1316.