Fast Onset Medications through Thermally Generated Aerosols

Journal of Pharmacology and Experimental Therapeutics

Volumn 309, Issue 2, 2004, Pages 769-775

  Rabinowitz, Joshua D ^a   Wensley, Martin ^a   Lloyd, Peter ^a   Myers, Daniel ^a   Shen, William ^a   Lu, Amy ^a   Hodges, Craig ^a   Hale, Ron ^a   Mufson, Daniel ^a   Zaffaroni, Alejandro ^a  

^a Alexza Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMIGRAINE AGENT; ATROPINE; METAL; MIDAZOLAM; RIZATRIPTAN; SILDENAFIL; ZOLPIDEM;

AEROSOL; ARTICLE; DEGRADATION; DRUG ABSORPTION; DRUG DECOMPOSITION; DRUG DELIVERY SYSTEM; DRUG EXPOSURE; FILM COATING; HEATING; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; RELIABILITY; VAPOR;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; DOGS; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; SEROTONIN AGENTS; SOLUTIONS; TRIAZOLES; TRYPTAMINES;

EID: 11144353889     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.062893     Document Type: Article

References (29)

1. Atkins PW (1990) Physical Chemistry, W. H. Freeman, New York.
2. Edwards DA, Hanes J, Caponetti G, Hrkach J, Ben-Jebria A, Eskew ML, Mintzes J, Deaver D, Lotan N, and Langer R (1997) Large porous particles for pulmonary drug delivery. Science (Wash DC) 276:1868-1871.
3. Ehrhardt C, Fiegel J, Fuchs S, Abu-Dahab R, Schaefer UF, Hanes J, and Lehr CM (2002) Drug absorption by the respiratory mucosa: cell culture models and particulate drug carriers. J Aerosol Med 15:131-139.
4. Farr SJ, Rowe AM, Rubsamen R, and Taylor G (1995) Aerosol deposition in the human lung following administration from a microprocessor controlled pressurised metered dose inhaler. Thorax 50:639-644.
5. Feniuk W, Humphrey PPA, and Perren MJ (1989) The selective carotid arterial vasoconstrictor action of GR43175 in anaesthetized dogs. Br J Pharmacol 96:83-90.
6. Freeman AS and Martin BR (1981) Quantification of phencyclidine in mainstream smoke and identification of phenylcydohex-1-ene as pyrolysis product. J Pharm Sci 70:1002-1004.
7. Friberg L, Olesen J, Iversen HK, and Sperling B (1991) Migraine pain associated with middle cerebral artery dilatation: reversal by sumatriptan. Lancet 338:13-17.
8. Friedlander SK (1977) Smoke Dust and Haze. John Wiley & Sons, New York.
9. Goldfarb T, Girtz ER, Jarvik ME, and Stolerman IP (1976) Reactions to cigarettes as a function of nicotine and "tar". Clin Pharm Ther 19:767-772.
10. Gonda I (1997) Particle deposition in the human respiratory tract, in The Lung: Scientific Foundations (Crystal RG, West JB, Barnes PJ, and Weibel ER eds) pp 2289-2294, Lippincott Williams & Wilkins, Philadelphia, PA.
11. Graves DA, Foster TS, Batenhorst RL, Bennett RL, and Baumann TJ (1983) Patient-controlled analgesia. Ann Internal Med 99:360-366.
12. Henry RR, Mudaliar SR, Howland WC, Chu N, Kim D, An B, and Reinhardt RR (2003) Dose-response relationships of inhaled insulin delivered via the Aerodose insulin inhaler and subcutaneously injected insulin in patients with type 2 diabetes. Diabetes Care 26:764-769.
13. Heyder J (1982) Particle transport onto human airway surfaces. Eur J Respir Dis Suppl 199:29-50.
14. Hinds WC (1999) Aerosol Technology: Properties, Behavior and Measurement of Airborne Particles, John Wiley & Sons, Inc., New York.
15. Hong JN, Hindle M, and Byron PR (2002) Control of particle size by coagulation of novel condensation aerosols in reservoir chambers. J Aerosol Med 15:359-368.
16. Johnson KA (1997) Preparation of peptide and protein powders for inhalation. Adv Drug Deliv Rev 26:3-15.
17. Kim CS, Trujillo D, and Sackner MA (1985) Size aspects of metered-dose inhaler aerosols. Am Rev Respir Dis 132:137-142.
18. Lee M, Jeng J, Hsiang W, and Hwang B (1999) Determination of pyrolysis products of smoked methamphetamine mixed with tobacco by tandem mass spectrometry. J Anal Toxicol 23:41-45.
19. Mather LW, Woodhouse A, Ward ME, Farr SJ, Rubsamen RA, and Eltherington LG (1998) Pulmonary administration of aerosolised fentanyl: pharmacokinetic analysis of systemic delivery. Br J Clin Pharmacol 46:37-43.
20. Martin BR, Lue LP, and Boni JP (1989) Pyrolysis and volatilization of cocaine. J Anal Toxicol 13:158-162.
21. Newhouse MT and Corkery KJ (2001) Aerosols for systemic delivery of macromolecules. Respir Care Clin N Am 7:261-275.
22. Porstendorfer J and Schraub A (1972) Concentration and mean particle size of the main and side stream of cigarette smoke. Staub-Reinhalt Luft 32:33-36.
23. Schmeltz I and Hoffmann D (1977) Nitrogen-containing compounds in tobacco and tobacco smoke. Chem Rev 77:295-311.
24. Schuster J, Rubsamen R, Lloyd P, and Lloyd J (1997) The AERX aerosol delivery system. Pharm Res (NY) 14:354-357.
25. Snyder CA, Wood RW, Graefe JF, Bowers A, and Magar K (1988) "Crack smoke" is a respirable aerosol of cocaine base. Pharmacol Biochem Behav 29:93-95.
26. Stedman RL (1968) The chemical composition of tobacco and tobacco smoke. Chem Rev 68:153-207.
27. Thippawong JB, Babul N, Morishige RJ, Findlay HK, Reber KR, Millward GJ, and Otulana BA (2003) Analgesic efficacy of inhaled morphine in patients after bunionectomy surgery. Anesthesiology 99:693-700.
28. Thurlbeck WM (1967) The internal surface area of nonemphysematous lungs. Am Rev Respir Dis 95:765-773.
29. West JB (1990) Respiratory Physiology - The Essentials, Lippincott Williams & Wilkins, Baltimore, MD.