Mutation of Y925F in focal adhesion kinase (FAK) suppresses melanoma cell proliferation and metastasis

Cancer Letters

Volumn 270, Issue 2, 2008, Pages 354-361

  Kaneda, Tomonori ^a   Sonoda, Yoshiko ^a   Ando, Kumi ^a   Suzuki, Takaharu ^a   Sasaki, Yasuhiro ^a   Oshio, Tomoyuki ^a   Tago, Megumi ^a   Kasahara, Tadashi ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

B16F10 cells; Erk; FAK; Metastasis; Paxillin; Y925F mutation

Indexed keywords

FOCAL ADHESION KINASE; PAXILLIN; PROTEIN TYROSINE KINASE; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ADHESION; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; MELANOMA; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; CELL ADHESION; CELL LINE, TUMOR; CELL PROLIFERATION; EXTRACELLULAR MATRIX; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FOCAL ADHESION KINASE 1; GENE EXPRESSION REGULATION, NEOPLASTIC; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MUTATION; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; PAXILLIN; PHOSPHORYLATION; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 52149083736     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.05.042     Document Type: Article

References (25)

1. Fidler I.J. The pathogenesis of cancer metastasis the 'seed and soil' hypothesis revisited. Nat. Rev. Cancer 3 (2003) 453-458
2. MacDonald I.C., Groom A.C., and Chambers A.F. Cancer spread and micrometastasis development: quantitative approaches for in vivo models. Bioessays 24 (2002) 885-893
3. Hendrix M.J., Seftor E.A., Seftor R.E., Kasemeier-Kulesa J., Kulesa P.M., and Postovit L.M. Reprogramming metastatic tumour cells with embryonic microenvironments. Nat. Rev. Cancer 7 (2007) 246-255
4. Uphal S., Bauer R., and Bosserhoff A.K. Integrin signaling in malignant melanoma. Cancer Metastasis Rev. 24 (2005) 195-222
5. Hanks S.K., Ryzhova L., Shin N.Y., and Brábek J. Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Front. Biosci. 8 (2003) 982-996
6. van Nimwegen M.J., and van de Water B. Focal adhesion kinase: a potential target in cancer therapy. Biochem. Pharmacol. 73 (2007) 597-609
7. Sonoda Y., Watanabe S., Matsumoto Y., Aizu-Yokota E., and Kasahara T. FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line. J. Biol. Chem. 274 (1999) 10566-10570
8. Sonoda Y., Matsumoto Y., Funakoshi M., Yamamoto D., Hanks S.K., and Kasahara T. Anti-apoptosis of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J. Biol. Chem. 275 (2000) 16309-16315
9. Chan P.C., Lai J.F., Cheng C.H., Tang M.J., Chiu C.C., and Chen H.C. Suppression of ultraviolet irradiation-induced apoptosis by overexpression of focal adhesion kinase in Madin-Darby canine kidney cells. J. Biol. Chem. 274 (1999) 26901-26906
10. Li X., Regezi J., Ross F.P., Blystone S., Ili D., Leong S.P., and Ramos D.M. Integrin alphavbeta3 mediates K1735 murine melanoma cell motility in vivo and in vitro. J. Cell Sci. 114 (2001) 2665-2672
11. Sawhney R.S., Cookson M.M., Omar Y., Hauser J., and Brattain M.G. Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway. J. Biol. Chem. 281 (2006) 8497-8510
12. Brunton V.G., Avizienyte E., Fincham V.J., Serrels B., Metcaf III C.A., Sawyer T.K., and Frame M.C. Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. Cancer Res. 65 (2005) 1335-1342
13. Burridge K. Foot in mouth: do focal adhesions disassemble by endocytosis?. Nat. Cell Biol. 7 (2005) 545-547
14. Ezratty E.J., Partridge M.A., and Gundersen G.G. Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase. Nat. Cell Biol. 7 (2005) 581-590
15. Raz A., Bucana C., McLellan W., and Fidler I.J. Distribution of membrane anionic sites on B16 melanoma variants with differing lung colonising potential. Nature 284 (1980) 363-364
16. Calalb M.B., Polte T.R., and Hanks S.K. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol. Cell. Biol. 15 (1995) 954-963
17. Silletti S., Yebra M., Perez B., Cirulli V., McMahon M., and Montgomery A.M. Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. J. Biol. Chem. 279 (2004) 28880-28888
18. Tsuji T., Kawada Y., Kai-Murozono M., Komatsu S., Han S.A., Takeuchi K., Mizushima H., Miyazaki K., and Irimura T. Regulation of melanoma cell migration and invasion by laminin-5 and alpha3beta1 integrin (VLA-3). Clin. Exp. Metastasis 19 (2002) 127-134
19. Danen E.H.J., and Yamada K.M. Fibronectin, integrins, and growth control. J. Cell Physiol. 189 (2001) 1-13
20. Mitra S.K., Mikolon D., Molina J.E., Hsia D.A., Hanson D.A., Chi A., Lim S.T., Bernard-Trifilo J.A., Ilic D., Stupack D.G., Cheresh D.A., and Schlaepfer D.D. Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors. Oncogene 25 (2006) 5969-5984
21. Trevino J.G., Summy J.M., Lesslie D.P., Parikh N.U., Hong D.S., Lee F.Y., Donato N.J., Abbruzzese J.L., Baker C.H., and Gallick G.E. Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model. Am. J. Pathol. 168 (2006) 962-972
22. Smith K.D., Wells A., and Lauffenburger D.A. Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts. Exp. Cell Res. 312 (2006) 1970-1982
23. Carragher N.O., Levkau B., Ross R., and Raines E.W. Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talin. J. Cell Biol. 147 (1999) 619-623
24. Brown M.C., and Turner C.E. Paxillin: adapting to change. Physiol. Rev. 84 (2004) 1315-1339
25. Webb D.J., Donais K., Whitmore L.A., Thomas S.M., Turner C.E., Parsons J.T., and Horwitz A.F. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat. Cell Biol. 6 (2004) 154-161