Protein kinase A (PKA) isoform RIIβ mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells

Journal of Biological Chemistry

Volumn 283, Issue 32, 2008, Pages 21920-21925

  Ji, Zhenyu ^a   Mei, Fang C ^a   Miller, Aaron L ^a   Thompson, E Brad ^a   Cheng, Xiaodong ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CLONING; ENZYME ACTIVITY; LAWS AND LEGISLATION;

ACUTE LYMPHOBLASTIC LEUKEMIAS; APOPTOSIS; CELL KILLINGS; CELLULAR ACTIVITIES; EXCHANGE PROTEINS; EXPRESSION LEVELS; FORSKOLIN; GLUCOCORTICOID; INDUCED APOPTOSIS; ISOFORM; LYMPHOID CELLS; LYMPHOID MALIGNANCIES; PKA ACTIVITIES; PROTEIN KINASES; REGULATORY SUBUNITS; SYNERGISTIC EFFECTS;

FETAL MONITORING;

ADENYLATE CYCLASE; COMPLEMENTARY DNA; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN D; DEXAMETHASONE; FORSKOLIN; GLUCOCORTICOID; PROTEIN BCL 2; SHORT HAIRPIN RNA; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IIBETA; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; ONCOPROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL STRAIN HEK293; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBUNIT; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LENTIVIRINAE; LEUKEMIA CELL; LYMPHOID CELL; PHENOTYPE; PRIORITY JOURNAL; RETROVIRUS INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; DRUG RESISTANCE; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; LYMPHATIC LEUKEMIA; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; CELL LINE, TUMOR; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIIBETA SUBUNIT; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOCORTICOIDS; HUMANS; ONCOGENE PROTEIN V-AKT; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 52049119312     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803193200     Document Type: Article

References (31)

1. Kofler, R. (2000) Histochem. Cell Biol. 114, 1-7
2. Kofler, R., Schmidt, S., Kofler, A., and Ausserlechner, M. J. (2003) J. Endocrinol. 178, 19-27
3. Hongo, T., Yajima, S., Sakurai, M., Horikoshi, Y., and Hanada, R. (1997) Blood 89, 2959-2965
4. Kaspers, G. J., Pieters, R., Van Zantwijk, C. H., van Wering, E. R., Van Der Does-Van Den Berg, and Veerman, A. J. (1998) Blood 92, 259-266
5. Moalli, P. A., and Rosen, S. T. (1994) Leuk. Lymphoma 15, 363-374
6. Tissing, W. J., Meijerink, J. P., den Boer, M. L., and Pieters, R. (2003) Leukemia (Basingstoke) 17, 17-25
7. Klumper, E., Pieters, R., Veerman, A. J., Huismans, D. R., Loonen, A. H., Hahlen, K., Kaspers, G. J., van Wering, E. R., Hartmann, R., and Henze, G. (1995) Blood 86, 3861-3868
8. Medh, R. D., Saeed, M. F., Johnson, B. H., and Thompson, E. B. (1998) Cancer Res. 58, 3684-3693
9. Ji, Z., Mei, F. C., Johnson, B. H., Thompson, E. B., and Cheng, X. (2007) J. Biol. Chem. 282, 37370-37377
10. Cho-Chung, Y. S., Pepe, S., Clair, T., Budillon, A., and Nesterova, M. (1995) Crit. Rev. Oncol.-Hematol. 21, 33-61
11. Taylor, S. S., Buechler, J. A., and Yonemoto, W. (1990) Annu. Rev. Biochem. 59, 971-1005
12. Lee, D. C., Carmichael, D. F., Krebs, E. G., and McKnight, G. S. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 3608-3612
13. Clegg, C. H., Cadd, G. G., and McKnight, G. S. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 3703-3707
14. Scott, J. D., Glaccum, M. B., Zoller, M. J., Uhler, M. D., Helfman, D. M., McKnight, G. S., and Krebs, E. G. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 5192-5196
15. Jahnsen, T., Hedin, L., Kidd, V. J., Beattie, W. G., Lohmann, S. M., Walter, U., Durica, J., Schulz, T. Z., Schiltz, E., and Browner, M. (1986) J. Biol. Chem. 261, 12352-12361
16. Beebe, S. J., Oyen, O., Sandberg, M., Froysa, A., Hansson, V., and Jahnsen, T. (1990) Mol. Endocrinol. 4, 465-475
17. Cheng, X., Phelps, C., and Taylor, S. S. (2001) J. Biol. Chem. 276, 4102-4108
18. Beavo, J. A., Bechtel, P. J., and Krebs, E. G. (1974) Proc. Natl. Acad. Sci. U. S. A. 71, 3580-3583
19. Mei, F. C., Qiao, J., Tsygankova, O. M., Meinkoth, J. L., Quilliam, L. A., and Cheng, X. (2002) J. Biol. Chem. 277, 11497-11504
20. Zhang, L., and Insel, P. A. (2004) J. Biol. Chem. 279, 20858-20865
21. Miller, A. L., Webb, M. S., Copik, A. J., Wang, Y., Johnson, B. H., Kumar, R., and Thompson, E. B. (2005) Mol. Endocrinol. 19, 1569-1583
22. Brandon, E. P., Logue, S. F., Adams, M. R., Qi, M., Sullivan, S. P., Matsumoto, A. M., Dorsa, D. M., Wehner, J. M., McKnight, G. S., and Idzerda, R. L. (1998) J. Neurosci. 18, 3639-3649
23. Danel-Moore, L., Kawa, S., Kalmaz, G. D., Bessman, D., and Thompson, E. B. (1993) Leuk. Res. 17, 501-506
24. Norman, M. R., and Thompson, E. B. (1977) Cancer Res. 37, 3785-3791
25. Kim, S., Jee, K., Kim, D., Koh, H., and Chung, J. (2001) J. Biol. Chem. 276, 12864-12870
26. Hanahan, D., and Weinberg, R. A. (2000) Cell 100, 57-70
27. Fesik, S. W. (2005) Nat. Rev. Cancer 5, 876-885
28. Holleman, A., Cheok, M. H., den Boer, M. L., Yang, W., Veerman, A. J., Kazemier, K. M., Pei, D., Cheng, C., Pui, C. H., Relling, M. V., Janka-Schaub, G. E., Pieters, R., and Evans, W. E. (2004) N. Engl. J. Med. 351, 533-542
29. Wei, G., Twomey, D., Lamb, J., Schlis, K., Agarwal, J., Stam, R. W., Opferman, J. T., Sallan, S. E., den Boer, M. L., Pieters, R., Golub, T. R., and Armstrong, S. A. (2006) Cancer Cell 10, 331-342
30. Miller, A. L., Garza, A. S., Johnson, B. H., and Thompson, E. B. (2007) Cancer Cell Int. 7, 3
31. Myklebust, J. H., Josefsen, D., Blomhoff, H. K., Levy, F. O., Naderi, S., Reed, J. C., and Smeland, E. B. (1999) J. Cell Physiol. 180, 71-80