VEGF signaling on hematopoietic precursors restricts B-lymphoid commitment in vitro and in vivo

Experimental Hematology

Volumn 36, Issue 10, 2008, Pages

  Fragoso, Rita ^a   Igreja, Cátia ^a   Clode, Nuno ^b   Henriques, Alexandra ^b   Appleton, Cláudia ^b   Zhu, Zhenping ^d   Wu, Yan ^d   Dias, Sérgio ^a,c,e  

^a INSTITUTO PORTUGUÊS DE ONCOLOGIA DE LISBOA FRANCISCO GENTIL   (Portugal)

^b HOSPITAL DE SANTA MARIA   (Portugal)

^c INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^d ELI LILLY AND COMPANY   (United States)

^e INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CD34 SELECTION; CELL DIFFERENTIATION; CONTROLLED STUDY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; INFLAMMATION; LYMPHOID CELL; LYMPHOPOIESIS; MOUSE; MYELOPOIESIS; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH;

MURINAE; MUS;

EID: 52049106841     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2008.04.023     Document Type: Article

References (25)

1. Choi K., Kennedy M., Kazarov A., Papadimitriou J.C., and Keller G. A common precursor for hematopoietic and endothelial cells. Development 125 (1998) 725-732
2. Kabrun N., Buhring H.J., Choi K., Ullrich A., Risau W., and Keller G. Flk-1 expression defines a population of early embryonic hematopoietic precursors. Development 124 (1997) 2039-2048
3. Gerber H.P., Malik A.K., Solar G.P., et al. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism. Nature 417 (2002) 954-958
4. Larrivee B., Lane D.R., Pollet I., Olive P.L., Humphries R.K., and Karsan A. Vascular endothelial growth factor receptor-2 induces survival of hematopoietic progenitor cells. J Biol Chem 278 (2003) 22006-22013
5. Miyagi T., Takeno M., Nagafuchi H., Takahashi M., and Suzuki N. Flk1+ cells derived from mouse embryonic stem cells reconstitute hematopoiesis in vivo in SCID mice. Exp Hematol 30 (2002) 1444-1453
6. Gabrilovich D., Ishida T., Oyama T., et al. Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood 92 (1998) 4150-4166
7. Dikov M.M., Ohm J.E., Ray N., et al. Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation. J Immunol 174 (2005) 215-222
8. Huang Y., Chen X., Dikov M.M., et al. Distinct roles of VEGFR-1 and -2 in the aberrant hematopoiesis associated with elevated levels of VEGF. Blood 15 (2007) 624-631
9. Ohm J.E., Gabrilovich D.I., Sempowski G.D., et al. VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression. Blood 101 (2003) 4878-4886
10. Larrivee B., Pollet I., and Karsan A. Activation of vascular endothelial growth factor receptor-2 in bone marrow leads to accumulation of myeloid cells: role of granulocyte-macrophage colony-stimulating factor. J Immunol 175 (2005) 3015-3024
11. Rafii S., Avecilla S., Shmelkov S., et al. Angiogenic factors reconstitute hematopoiesis by recruiting stem cells from bone marrow microenvironment. Ann N Y Acad Sci 996 (2003) 49-60
12. Hattori K., Heissig B., Wu Y., et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nat Med 8 (2002) 841-849
13. Heissig B., Hattori K., Dias S., et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 109 (2002) 625-637
14. Fluckiger A.C., Sanz E., Garcia-Lloret M., et al. In vitro reconstitution of human B-cell ontogeny: from CD34(+) multipotent progenitors to Ig-secreting cells. Blood 92 (1998) 4509-4520
15. Matthias P., and Rolink A.G. Transcriptional networks in developing and mature B cells. Nat Rev Immunol 5 (2005) 497-508
16. Gehling U.M., Ergun S., Schumacher U., et al. In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Blood 95 (2002) 3106-3112
17. Gerber H.P., Dixit V., and Ferrara N. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J Biol Chem 273 (1998) 13313-13316
18. Ferrara N., and Henzel W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem Biophys Res Commun 161 (1989) 851-858
19. Gerber H.P., and Ferrara N. The role of VEGF in normal and neoplastic hematopoiesis. J Mol Med 81 (2003) 20-31
20. Fragoso R., Pereira T., Wu Y., Zhu Z., Cabecadas J., and Dias S. VEGFR-1 (FLT-1) activation modulates acute lymphoblastic leukemia localization and survival within the bone marrow, determining the onset of extramedullary disease. Blood 107 (2006) 1608-1616
21. Barleon B., Sozzani S., Zhou D., Weich H.A., Mantovani A., and Marme D. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87 (1996) 3336-3343
22. Hiratsuka S., Minowa O., Kuno J., Noda T., and Shibuya M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci U S A 95 (1998) 9349-9354
23. Casella I., Feccia T., Chelucci C., et al. Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor. Blood 101 (2003) 1316-1323
24. Dias S., Hattori K., Zhu Z., et al. Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration. J Clin Invest 106 (2000) 511-521
25. Dias S., Hattori K., Heissig B., et al. Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias. Proc Natl Acad Sci U S A 98 (2001) 10857-10862