Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation

Biochemical and Biophysical Research Communications

Volumn 376, Issue 1, 2008, Pages 158-163

  Cho, Seung Woo ^a   Hartle, Lauren ^b   Son, Sun Mi ^a   Yang, Fan ^a   Goldberg, Michael ^c   Xu, Qiaobing ^a   Langer, Robert ^a,c   Anderson, Daniel G ^c  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Apoptosis; Endothelial cell; Hypoxia; RNA interference; Serum deprivation

Indexed keywords

ANGIOGENIC FACTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LIPOSOME; PROTEIN BAX; PROTEIN BCL XL; PROTEIN TYROSINE PHOSPHATASE SHP 1; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 1; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYPOXIA; ISCHEMIA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; RNA SYNTHESIS; SERUM; SIMULATION; UMBILICAL VEIN;

APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIAL CELLS; HUMANS; ISCHEMIA; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RNA INTERFERENCE; RNA, SMALL INTERFERING; SERUM; TRANSFECTION;

EID: 52049101120     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.08.123     Document Type: Article

References (24)

1. Lee C.N., Cheng W.F., Chang M.C., Su Y.N., Chen C.A., and Hsieh F.J. Hypoxia-induced apoptosis in endothelial cells and embryonic stem cells. Apoptosis 10 (2005) 887-894
2. Hogg N., Browning J., Howard T., Winterford C., Fitzpatrick D., and Gobé G. Apoptosis in vascular endothelial cells caused by serum deprivation, oxidative stress and transforming growth factor-beta. Endothelium 7 (1999) 35-49
3. Matsushita H., Morishita R., Nata T., Aoki M., Nakagami H., Taniyama Y., Yamamoto K., Higaki J., Yasufumi K., and Ogihara T. Hypoxia-induced endothelial apoptosis through nuclear factor-kappaB (NF-kappaB)-mediated bcl-2 suppression: in vivo evidence of the importance of NF-kappaB in endothelial cell regulation. Circ. Res. 86 (2000) 974-981
4. Meeson A.P., Argilla M., Ko K., Witte L., and Lang R.A. VEGF deprivation-induced apoptosis is a component of programmed capillary regression. Development 126 (1999) 1407-1415
5. Nakagami H., Cui T.X., Iwai M., Shiuchi T., Takeda-Matsubara Y., Wu L., and Horiuchi M. Tumor necrosis factor-α inhibits growth factor-mediated cell proliferation through SHP-1 activation in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 238-242
6. Guo D.Q., Wu L.W., Dunbar J.D., Ozes O.N., Mayo L.D., Kessler K.M., Gustin J.A., Baerwald M.R., Jaffe E.A., Warren R.S., and Donner D.B. Tumor necrosis factor employs a protein-tyrosine phosphatase to inhibit activation of KDR and vascular endothelial cell growth factor-induced endothelial cell proliferation. J. Biol. Chem. 275 (2000) 11216-11221
7. Sugano M., Tsuchida K., Tomita H., and Makino N. Increased proliferation of endothelial cells with overexpression of soluble TNF-alpha receptor I gene. Atherosclerosis 162 (2002) 77-84
8. Seo D.W., Li H., Qu C.K., Oh J., Kim Y.S., Diaz T., Wei B., Han J.W., and Stetler-Stevenson W.G. Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells. J. Biol. Chem. 281 (2006) 3711-3721
9. Bhattacharya R., Kwon J., Wang E., Mukherjee P., and Mukhopadhyay D. Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration. J. Mol. Signal. 3 (2008) 8
10. Mizuno K., Tagawa Y., Mitomo K., Watanabe N., Katagiri T., Ogimoto M., and Yakura H. Src homology region 2 domain-containing phosphatase 1 positively regulates B cell receptor-induced apoptosis by modulating association of B cell linker protein with Nck and activation of c-Jun NH2-terminal kinase. J. Immunol. 169 (2000) 778-786
11. Thangaraju M., Sharma K., Leber B., Andrews D.W., Shen S.H., and Srikant C.B. Regulation of acidification and apoptosis by SHP-1 and Bcl-2. J. Biol. Chem. 274 (1999) 29549-29557
12. Sugano M., Tsuchida K., Hata T., and Makino N. RNA interference targeting SHP-1 attenuates myocardial infarction in rats. FASEB J. 19 (2005) 2054-2056
13. Wishcamper C.A., Brooks D.M., Douglas Coffin J., and Lurie D.I. Focal cerebral ischemia upregulates SHP-1 in reactive astrocytes in juvenile mice. Brain Res. 974 (2003) 88-98
14. Sugano M., Koyanagi M., Tsuchida K., Hata T., and Makino N. In vivo gene transfer of soluble TNF-alpha receptor 1 alleviates myocardial infarction. FASEB J. 16 (2002) 1421-1422
15. Sugano M., Tsuchida K., and Makino N. Intramuscular gene transfer of soluble tumor necrosis factor-alpha receptor 1 activates vascular endothelial growth factor receptor and accelerates angiogenesis in a rat model of hindlimb ischemia. Circulation 109 (2004) 797-802
16. Krichevsky A.M., and Kosik K.S. RNAi functions in cultured mammalian neurons. Proc. Natl. Acad. Sci. USA 99 (2002) 11926-11929
17. Kim J., Moon S.H., Lee S.H., Lee D.R., Koh G.Y., and Chung H.M. Effective isolation and culture of endothelial cells in embryoid body differentiated from human embryonic stem cells. Stem Cells Dev. 16 (2007) 269-280
18. Lai P.F., Mohamed F., Monge J.C., and Stewart D.J. Downregulation of eNOS mRNA expression by TNFalpha: identification and functional characterization of RNA-protein interactions in the 3′UTR. Cardiovasc. Res. 59 (2003) 160-168
19. Anderson H.D., Rahmutula D., and Gardner D.G. Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. J. Biol. Chem. 279 (2004) 963-969
20. Shen B.Q., Lee D.Y., and Zioncheck T.F. Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway. J. Biol. Chem. 274 (1999) 33057-33063
21. Pathak A.K., Bhutani M., Nair A.S., Ahn K.S., Chakraborty A., Kadara H., Guha S., Sethi G., and Aggarwal B.B. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol. Cancer Res. 5 (2007) 943-955
22. Daigle I., Yousefi S., Colonna M., Green D.R., and Simon H.U. Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils. Nat. Med. 8 (2002) 61-67
23. Lucas R., Garcia I., Donati Y.R., Hribar M., Mandriota S.J., Giroud C., Buurman W.A., Fransen L., Suter P.M., Nunez G., Pepper M.S., and Grau G.E. Both TNF receptors are required for direct TNF-mediated cytotoxicity in microvascular endothelial cells. Eur. J. Immunol. 28 (1998) 3577-3586
24. Aragonés J., Schneider M., Van Geyte K., Fraisl P., Dresselaers T., Mazzone M., Dirkx R., Zacchigna S., Lemieux H., Jeoung N.H., Lambrechts D., Bishop T., Lafuste P., Diez-Juan A., Harten S.K., Van Noten P., De Bock K., Willam C., Tjwa M., Grosfeld A., Navet R., Moons L., Vandendriessche T., Deroose C., Wijeyekoon B., Nuyts J., Jordan B., Silasi-Mansat R., Lupu F., Dewerchin M., Pugh C., Salmon P., Mortelmans L., Gallez B., Gorus F., Buyse J., Sluse F., Harris R.A., Gnaiger E., Hespel P., Van Hecke P., Schuit F., Van Veldhoven P., Ratcliffe P., Baes M., Maxwell P., and Carmeliet P. Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat. Genet. 40 (2008) 170-180