The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy

PLoS ONE

Volumn 3, Issue 7, 2008, Pages

  Ahmad, Ferhaan ^a,b,c   Banerjee, Sanjay K ^a   Lage, Michele L ^a   Huang, Xueyin N ^a   Smith, Stephen H ^d   Saba, Samir ^a   Rager, Jennifer ^a   Conner, David A ^c   Janczewski, Andrzej M ^d   Tobita, Kimimasa ^e   Tinney, Joseph P ^e   Moskowitz, Ivan P ^f   Perez Atayde, Antonio R ^f   Keller, Bradley B ^e   Mathier, Michael A ^a   Shroff, Sanjeev G ^d   Seidman, Christine E ^c   Seidman, J G ^c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d University of Pittsburgh   (United States)

^e CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^f BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; TROPONIN T;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CROSS BREEDING; DISEASE SEVERITY; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE OVEREXPRESSION; HEART DEVELOPMENT; HEART ELECTROPHYSIOLOGY; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART MUSCLE CONTRACTILE FORCE; HEART VENTRICLE WALL; HETEROZYGOSITY; HISTOPATHOLOGY; HOMOZYGOSITY; MOUSE; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PERICARDIAL EFFUSION; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; SARCOMERE LENGTH; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; ECHOCARDIOGRAPHY; EMBRYO (ANATOMY); GENETICS; HEART; HEART MUSCLE; HYPERTROPHIC CARDIOMYOPATHY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; PRENATAL DEVELOPMENT;

MUS; MUS MUSCULUS;

ANIMALS; CARDIOMYOPATHY, DILATED; CARDIOMYOPATHY, HYPERTROPHIC; ECHOCARDIOGRAPHY; EMBRYO, MAMMALIAN; HEART; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCARDIUM; PHENOTYPE; TROPONIN T;

EID: 50249146466     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002642     Document Type: Article

References (33)

1. Ahmad F, Seidman JG, Seidman GE (2005) The genetic basis for cardiac remodeling. Annu Rev Genomics Hum Genet 6: 185-216.
2. Kamisago M, Sharma SD, DePalma SR, Solomon S, Sharma P, et al. (2000) Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy. N Engl J Med 343: 1688-96.
3. Blanchard EM, Iizuka K, Christe M, Conner DA, Geisterfer-Lowrance A, et al. (1997) Targeted ablation of the murine alpha-tropomyosin gene. Girc Res 81: 1005-10.
4. Rethinasamy P, Muthuchamy M, Hewett T, Boivin G, Wolska BM, et al. (1998) Molecular and physiological effects of alpha-tropomyosin ablation in the mouse. Circ Res 82: 116-23.
5. Harris SP, Bartley CR, Hacker TA, McDonald KS, Douglas PS, et al. (2002) Hypertrophic cardiomyopathy in cardiac myosin binding protein-G knockout mice. Girc Res 90: 594-601.
6. Huang X, Pi Y, Lee KJ, Henkel AS, Gregg RG, et al. (1999) Cardiac troponin I gene knockout: a mouse model of myocardial troponin I deficiency. Circ Res 84: 1-8.
7. Hernandez OM, Szczesna-Cordary D, Knollmann BC, Miller T, Bell M, et al. (2005) F110I and R278G troponin T mutatious that cause familial hypertrophic cardiomyopathy affect muscle contraction in transgenic mice and reconstituted human cardiac fibers. J Biol Chem 280: 37183-94.
8. Gafurov B, Fredricksen S, Cai A, Brenner B, Chase PB, et al. (2004) The Delta 14 mutation of human cardiac troponin T enhances ATPase activity and alters the cooperative binding of S1-ADP to regulated actin. Biochemistry 43: 15276-85.
9. Chandra M, Rundell VL, Tardiff JC, Leinwand LA, De Tombe PP, et al. (2001) Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T. Am J Physiol Heart Circ Physiol 280: H705-H713.
10. Montgomery DE, Tardiff JC, Chandra M (2001) Cardiac troponin T mutations: correlation between the type of mutation and the nature of myofilament dysfunction in transgenic mice. J Physiol 536: 583-592.
11. Morimoto S, Yanaga F, Minakami R, Ohtsuki I (1998) Ga2+-sensitizing effects of the mutations at Ile-79 and Arg-92 of troponin T in hypertrophic cardiomyopathy. Am J Physiol 275: C200-7.
12. Yanaga F, Morimoto S, Ohtsuki I (1999) Ca2+ sensitization and potentiation of the maximum level of myofibrillar ATPase activity caused by mutations of troponin T found in familial hypertrophic cardiomyopathy. J Biol Chem 274: 8806-12.
13. Mirza M, Marston S, Willott R, Ashley C, Mogeusen J, et al. (2005) Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype. J Biol Chem 280: 28498-506.
14. Venkatraman G, Gomes AV, Kerrick WG, Potter JD (2005) Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform. J Biol Chem 280: 17584-92.
15. Morimoto S, Lu Q W, Harada K, Takahashi-Yanaga F, Minakami R, et al. (2002) Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy. Proc. Natl. Acad. Sci. U.S.A 99: 913-918.
16. Lu Q W, Morimoto S, Harada K, Du CK, Takahashi-Yanaga F, et al. (2003) Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T-tropomyosin interaction and causes a Ca2+ desensitization. J Mol Cell Cardiol 35: 1421-7.
17. Robinson P, Mirza M, Knott A, Abdulrazzak H, Willott R, et al. (2002) Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy. J Biol Chem 277: 40710-6.
18. Venkatraman G, Harada K, Gomes AV, Kerrick WG, Potter JD (2003) Different functional properties of troponin T mutants that cause dilated cardiomyopathy. J Biol Chem 278: 41670-6.
19. Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, et al. (2001) A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106: 709-21.
20. Gulick J, Subramaniam A, Neumann J, Robbins J (1991) Isolation and characterization of the mouse cardiac myosin heavy chain genes. J Biol Chem 266: 9180-5.
21. Ramani R, Mathier M, Wang P, Gibson G, Togel S, et al. (2004) Inhibition of tumor necrosis factor receptor-1-mediated pathways has beneficial effects in a murine model of postischemic remodeling. Am J Physiol Heart Circ Physiol 287: H1369-77.
22. Ahmad F, Arad M, Musi N, He H, Wolf C, et al. (2005) Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy. Circulation 112: 3140-3148.
23. Chen HH, Baty CJ, Maeda T, Brooks S, Baker LC, et al. (2004) Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation. Circulation 110: 2980-7.
24. Saba S, Janczewski AM, Baker LC, Shusterman V, Gursoy EG, et al. (2005) Atrial contractile dysfunction, fibrosis, and arrhythmias in a mouse model of cardiomyopathy secondary to cardiac-specific overexpression of tumor necrosis factor-{alpha}. Am J Physiol Heart Circ Physiol 289: H1456-67.
25. Adhikari BB, Regnier M, Rivera AJ, Kreutziger KL, Martyn DA (2004) Cardiac length dependence of force and force redevelopment kinetics with altered crossbridge cycling. Biophys J 87: 1784-94.
26. Sehnert AJ, Huq A, Weinstein BM, Walker C, Fishman M, et al. (2002) Cardiac troponin T is essential in sarcomere assembly and cardiac contractility. Nat Genet 31: 106-10.
27. Fyrberg E, Fyrberg CC, Beall C, Saville DL (1990) Drosophila melanogaster troponin-T mutations engender three distinct syndromes of myofibrillar abnormalities. J Mol Biol 216: 657-75.
28. Henderson SA, Goldhaber JI, So JM, Han T, Motter C, et al. (2004) Functional adult myocardium in the absence of Na+Ca2+ exchange: cardiac-specific knockout of NCX1. Circ Res 95: 604-11.
29. Hurtado C, Ander BP, Maddaford TG, Lukas A, Hryshko LV, et al. (2005) Adenovirally delivered shRNA strongly inhibits Na+-Ca2+ exchanger expression but does not prevent contraction of neonatal cardiomyocytes. J Mol Cell Cardiol 38: 647-54.
30. James J, Zhang Y, Osinska H, Sanbe A, Klevitsky R, et al. (2000) Transgenic modeling of a cardiac troponin I mutation linked to familial hypertrophic cardiomyopathy. Circ Res 87: 805-11.
31. Du CK, Morimoto S, Nishii K, Minakami R, Ohta M, et al. (2007) Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation. Circ Res 101: 185-94.
32. Schmitt JP, Debold EP, Ahmad F, Armstrong A, Frederico A, et al. (2006) Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. Proc Natl Acad Sci U S A 103: 14525-30.
33. Sirenko SG, Potter JD, Knollmann BC (2006) Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts-role of myofilament Ca2+ sensitivity increase. J Physiol 575: 201-13.