Pro-apoptotic effects of anti-β1-adrenergic receptor antibodies in cultured rat cardiomyocytes: Actions on endoplasmic reticulum and the prosurvival PI3K-Akt pathway

Autoimmunity

Volumn 41, Issue 6, 2008, Pages 434-441

  Liang, Chang Seng ^a   Mao, Weike ^a   Liu, Jiahao ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Caspase 12, Akt; Myocyte apoptosis; P38 MAP kinase

Indexed keywords

AUTOANTIBODY; BETA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR ANTIBODY; CALCIUM ION; CASPASE 12; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE B; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CALCIUM CELL LEVEL; CELL STRESS; CELL SURVIVAL; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; HEART CELL CULTURE; HEART MUSCLE CELL; IMMUNOPATHOGENESIS; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROCESSING; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIBODIES; APOPTOSIS; AUTOIMMUNE DISEASES; CARDIOMYOPATHIES; CASPASE 12; CELLS, CULTURED; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; IMMUNOGLOBULIN G; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTORS, ADRENERGIC, BETA-1; SIGNAL TRANSDUCTION;

EID: 51849154376     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930802031710     Document Type: Article

References (20)

1. 1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure. Circulation, 99, pp. 649-654.
2. Iwata, M., Yoshikawa, T., Baba, A., Anzai, T., Mitamura, H. and Ogawa, S. (2001) Autoantibodies against the second extracellular loop of beta1-adrenergic receptors predict ventricular tachycardia and sudden death in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol, 37, pp. 418-424.
3. 1-adrenoceptor autoantibodies with chronotropic activity from the serum of patients with dilated cardiomyopathy: Mapping of epitopes in the first and second extracellular loops. J Mol Cell Cardiol, 27, pp. 397-406.
4. 1-adrenoceptor antibodies induce apoptosis in adult isolated cardiomyocytes. Eur J Pharmacol, 466, pp. 1-6.
5. Staudt, A., Staudt, Y., Dorr, M., Bohm, M., Knebel, F., Hummel, A., Wunderle, L., Tiburcy, M., Wernecke, KD, Baumann, G. and Felix, SB (2004) Potential role of humoral immunity in cardiac dysfunction of patients suffering from dilated cardiomyopathy. J Am Coll Cardiol, 44, pp. 829-836.
6. 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest, 113, pp. 1419-1429.
7. -/- mouse: Participation of the ER stress. J Mol Cell Cardiol, 44, pp. 304-314.
8. 1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmue cardiomyopathy improved cardiac structure and function. J Mol Cell Cardiol, 41, pp. 78-85.
9. 1-adrenergic antibodies from patients with idiopathic dilated cardiomyopathy. N Engl J Med, 347, p. 1806.
10. Mao, W., Fukuoka, S., Iwai, C., Liu, J., Sharma, VL, Sheu, SS, Fu, M. and Liang, C-S (2007) Cardiomyocyte apoptosis in autoimmune cardiomyopathy: Mediated via endoplasmic reticulum stress and exaggerated by norepinephrine. Am J Physiol Heart Circ Physiol, 293, pp. H1636-H1645.
11. Lamkanfi, M., Kalai, M. and Vandenabeele, P. (2004) Caspase-12: An overview. Cell Death Differ, 11, pp. 365-368.
12. Morishima, N., Nakanishi, K., Takenouchi, H., Shibata, T. and Yasuhiko, Y. (2002) An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem, 277, pp. 34287-34294.
13. 2+ disturbance, and cell death in renal epithelial cells. J Biol Chem, 272, pp. 21751-21759.
14. Rao, RV, Hermel, E., Castro-Obregon, S., del Rio, G, Ellerby, LM, Ellerby, HM and Bredesen, DE (2001) Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J Biol Chem, 276, pp. 33869-33874.
15. Rao, RV, Peel, A., Logvinova, A., del Rio, G, Hermel, E., Yokota, T., Goldsmith, PC, Ellerby, LM, Ellerby, HM and Bredesen, DE (2002) Coupling endoplasmic reticulum stress to the cell death program: Role of the ER chaperone GRP78. FEBS Lett, 514, pp. 122-128.
16. 2+ induced p38 MAP kinase activation. EMBO Rep, 5, pp. 161-166.
17. Staudt, A., Eichler, P., Trimpert, C., Felix, SB and Greinacher, A. (2007) Fcγ receptors IIa on cardiomyocytes and their potential functional relevance in dilated cardiomyopathy. J Am Coll Cardiol, pp. 1684-1692.
18. Mao, W., Iwai, C., Keng, P., Vulapalli, R. and Liang, C-S (2006) NE-induced oxidative stress causes PC12 cell apoptosis by both ER stress and mitochondrial intrinsic pathway: Inhibition of the phosphatidylinositol 3-kinase survival pathway. Am J Physiol Cell Physiol, 290, pp. C1373-C1384.
19. Srinivasan, S., Ohsugi, M., Liu, Z., Fatrai, S., Bernaal-Mizrachi, E. and Permutt, MA (2005) Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3β in mouse insulinoma cells. Diabetes, 54, pp. 968-975.
20. Hyoda, K., Hosoi, T., Horie, N., Okuma, Y., Ozawa, K. and Nomura, Y. (2006) PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells. Biochem Biophys Res Commun, 340, pp. 286-290.