Quantitative renal cortical perfusion in human subjects with magnetic resonance imaging using iron-oxide nanoparticles: Influence of T1 shortening

Acta Radiologica

Volumn 49, Issue 8, 2008, Pages 955-962

  Morell, A ^a,b   Ahlstrom, H ^c   Schoenberg, S O ^c   Abildgaard, A ^c   Bock, M ^c   Bjrnerud, A ^c  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b Diagnostic Radiology   (Sweden)

^c NONE

Author keywords

Contrast agents; Dynamic susceptibility contrast MRI (DSC MRI); Intravascular; Kidney; MR diffusion perfusion

Indexed keywords

AGENTS; ATOMS; BLOOD; GRADIENT METHODS; HEMODYNAMICS; IRON; IRON OXIDES; MAGNETIC FIELDS; MAGNETIC LEAKAGE; MAGNETIC RESONANCE; MAGNETIC RESONANCE IMAGING; MEDICAL IMAGING; NANOPARTICLES; NANOSTRUCTURES; RESONANCE;

BLOOD VOLUME; CONTRAST AGENT; CONTRAST AGENTS; CORTICAL BLOOD FLOW; CORTICAL PERFUSION; DYNAMIC SUSCEPTIBILITY CONTRAST MRI (DSC-MRI); ECHO DATA; HUMAN SUBJECTS; INTRAVASCULAR; KIDNEY; MEAN TRANSIT TIME; MEAN VALUES; MR DIFFUSION/PERFUSION; OXIDE NANO-PARTICLES; PERFUSION MEASUREMENTS; RELAXIVITY; RENAL ARTERY STENOSIS; T1 SHORTENING;

IMAGING TECHNIQUES;

CONTRAST MEDIUM; IRON; OXIDE; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE;

ARTICLE; CLINICAL TRIAL; HUMAN; KIDNEY ARTERY STENOSIS; KIDNEY CIRCULATION; KIDNEY CORTEX; METHODOLOGY; MULTICENTER STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY; VASCULARIZATION;

CONTRAST MEDIA; HUMANS; IRON; KIDNEY CORTEX; MAGNETIC RESONANCE IMAGING; OXIDES; RENAL ARTERY OBSTRUCTION; RENAL CIRCULATION;

EID: 51849153436     PISSN: 02841851     EISSN: 16000455     Source Type: Journal    
DOI: 10.1080/02841850802227139     Document Type: Article

References (23)

1. Aumann S, Schoenberg SO, Just A, Briley-Saebo K, Bjornerud A, Bock M, et al. Quantification of renal perfusion using an intravascular contrast agent (part 1): results in a canine model. Magn Reson Med 2003;49: 276-87.
2. Vallee JP, Lazeyras F, Khan HG, Terrier F. Absolute renal blood flow quantification by dynamic MRI and Gd-DTPA. Eur Radiol 2000;10:1245-52.
3. Williams DS, Zhang W, Koretsky AP, Adler S. Perfusion imaging of the rat kidney with MR. Radiology 1994;190:813-8.
4. Schoenberg SO, Aumann S, Just A, Bock M, Knopp MV, Johansson LO, et al. Quantification of renal perfusion abnormalities using an intravascular contrast agent (part 2): results in animals and humans with renal artery stenosis. Magn Reson Med 2003;49:288-98.
5. 2* effects in vivo and ex vivo using iron oxide nanoparticles in steady state - dependence on blood volume and water exchange. Magn Reson Med 2002;47:461-71.
6. 2 relaxivity in the kidney cortex of the pig - based on a two-compartment steady-state model. Magn Reson Imag 1998;16:933-42.
7. Bjornerud A, Johansson LO, Ahlstrom HK. Renal T(*)(2) perfusion using an iron oxide nanoparticle contrast agent - influence of T(1) relaxation on the first-pass response. Magn Reson Med 2002;47:298-304.
8. Bjornerud A, Briley-Saebo K, Johansson LO, Kellar KE. Effect of NC100150 injection on the (1)H NMR linewidth of human whole blood ex vivo: dependency on blood oxygen tension. Magn Reson Med 2000;44:803-7.
9. Kellar KE, Fujii DK, Gunther WH, Briley-Saebo K, Bjornerud A, Spiller M, et al. NC100150 Injection, a preparation of optimized iron oxide nanoparticles for positive-contrast MR angiography. J Magn Reson Imag 2000;11:488-94.
10. Rydland J, Bjornerud A, Haugen O, Torheim G, Torres C, Kvistad KA, et al. New intravascular contrast agent applied to dynamic contrast enhanced MR imaging of human breast cancer. Acta Radiol 2003;44:275-83.
11. Leiner T, Ho KY, Ho VB, Bongartz G, Mali WP, Rasch W, et al. Multicenter phase-II trial of safety and efficacy of NC100150 for steady-state contrast-enhanced peripheral magnetic resonance angiography. Eur Radiol 2003; 13:1620-7.
12. Briley Saebo K. Degradation, metabolism and relaxation properties of iron oxide particles for magnetic resonance imaging. Uppsala: Acta Universitatis Upsaliensis, Univ.-bibl. distributör; 2004.
13. Ostergaard L, Weisskoff RM, Chesler DA, Gyldensted C, Rosen BR. Highresolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: mathematical approach and statistical analysis. Magn Reson Med 1996;36:715-25.
14. Rempp KA, Brix G, Wenz F, Becker CR, Guckel F, Lorenz WJ. Quantification of regional cerebral blood flow and volume withdynamic susceptibility contrastenhanced MR imaging. Radiology 1994;193:637-41.
15. Dworkin LD, Brenner BM. The renal circulations. In: Brenner BM, Rector FC, editors. Brenner & Rector's the Kidney. 7th edn. Philadelphia, PA: Saunders; 2004. p. 309-52.
16. Giebisch G, Windhager E. Glomerular filtration and renal blood flow. In: Boron WF, Boulpaep EL, editors. Medical physiology: a cellular and molecular approach. Philadelphia, PA: Saunders; 2003. p. 757-73.
17. Greger R. Introduction to renal function, renal blood flow and the formation of filtrate. In: Greger R, Windhorst U, editors. Comprehensive human physiology: from cellular mechanisms to integration. Berlin: Springer; 1996. p. 1469-87.
18. Michoux N, Montet X, Pechere A, Ivancevic MK, Martin PY, Keller A, et al. Parametric and quantitative analysis of MR renographic curves for assessing the functional behaviour of the kidney. Eur J Radiol 2005; 54:124-35.
19. Roberts DA, Detre JA, Bolinger L, Insko EK, Lenkinski RE, Pentecost MJ, et al. Renal perfusion in humans: MR imaging with spin tagging of arterial water. Radiology 1995;196:281-6.
20. Karger N, Biederer J, Lusse S, Grimm J, Steffens J, Heller M, et al. Quantitation of renal perfusion using arterial spin labeling withFAIR-UFLARE. Magn Reson Imag 2000;18:641-7.
21. Martirosian P, Klose U, Mader I, Schick F. FAIR true-FISP perfusion imaging of the kidneys. Magn Reson Med 2004;51:353-61.
22. Butcher K, Parsons M, Baird T, Barber A, Donnan G, Desmond P, et al. Perfusion thresholds in acute stroke thrombolysis. Stroke 2003;34:2159-64.
23. Chinard FP, Enns T, Goresky CA, Nolan MF. Renal transit times and distribution volumes of T-1824, creatinine, and water. Am J Physiol 1965;209:243-52.