Changes in the rewarding effects induced by tramadol and its active metabolite M1 after sciatic nerve injury in mice

Psychopharmacology

Volumn 200, Issue 3, 2008, Pages 307-316

  Nakamura, Atsushi ^a   Narita, Minoru ^a   Miyoshi, Kan ^a   Shindo, Keiko ^a   Okutsu, Daiki ^a   Suzuki, Masami ^a   Higashiyama, Kimio ^a   Suzuki, Tsutomu ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Opioid receptor; Active metabolite M1; Dopamine; G protein activation; Neuropathic pain; Nucleus accumbens; Opioid receptor binding; Rewarding effect; Tramadol; Ventral tegmental area

Indexed keywords

BETA FUNALTREXAMINE; DOPAMINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MORPHINE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; O NORTRAMADOL; TRAMADOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DRUG RECEPTOR BINDING; HYPERALGESIA; IC 50; MALE; MICRODIALYSIS; MOUSE; NERVE INJURY; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; PRIORITY JOURNAL; REWARD; SCIATIC NERVE; TACTILE STIMULATION; THERMAL STIMULATION;

ANIMALS; CONDITIONING, OPERANT; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); INJECTIONS, SUBCUTANEOUS; LIGATION; MALE; MICE; MICE, INBRED ICR; NEURAL INHIBITION; NEURALGIA; NUCLEUS ACCUMBENS; PAIN THRESHOLD; REACTION TIME; RECEPTORS, OPIOID, MU; REWARD; SCIATIC NERVE; TRAMADOL; VENTRAL TEGMENTAL AREA;

EID: 51849150675     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-008-1180-1     Document Type: Article

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