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Volumn 21, Issue 3, 2008, Pages 315-325

Differences in clinical disease and immune response of pigs challenged with a high-dose versus low-dose inoculum of porcine reproductive and respiratory syndrome virus

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; INTERFERON; MYXOVIRUS RESISTANCE PROTEIN; PROTEIN KINASE; VIRUS RNA;

EID: 51849112932     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.2008.0038     Document Type: Conference Paper
Times cited : (24)

References (44)
  • 1
    • 0032536578 scopus 로고    scopus 로고
    • Immune responses in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV)
    • Albina E, Piriou L, Hutet E, Cariolet R, and L'Hospitalier R: Immune responses in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV). Vet Immunol Immunopathol 1998;61:49-66.
    • (1998) Vet Immunol Immunopathol , vol.61 , pp. 49-66
    • Albina, E.1    Piriou, L.2    Hutet, E.3    Cariolet, R.4    L'Hospitalier, R.5
  • 2
    • 0033761397 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus: Description of persistence in individual pigs upon experimental infection
    • Allende R, Laegreid WW, Kutish GF, Galeota JA, Wills RW, and Osorio FA: Porcine reproductive and respiratory syndrome virus: description of persistence in individual pigs upon experimental infection. J Virol 2000;74:10834-10837.
    • (2000) J Virol , vol.74 , pp. 10834-10837
    • Allende, R.1    Laegreid, W.W.2    Kutish, G.F.3    Galeota, J.A.4    Wills, R.W.5    Osorio, F.A.6
  • 4
    • 14944343546 scopus 로고    scopus 로고
    • The mRNA regulation of porcine double-stranded RNA-activated protein kinase gene
    • Asano A, Kon Y, and Agui T: The mRNA regulation of porcine double-stranded RNA-activated protein kinase gene. J Vet Med Sci 2004;66:1523-1528.
    • (2004) J Vet Med Sci , vol.66 , pp. 1523-1528
    • Asano, A.1    Kon, Y.2    Agui, T.3
  • 5
    • 0036628966 scopus 로고    scopus 로고
    • Viruses and the type I interferon antiviral system: Induction and evasion
    • Basler CF, and Garcia-Sastre A: Viruses and the type I interferon antiviral system: induction and evasion. Int Rev Immunol 2000;21:305-337.
    • (2000) Int Rev Immunol , vol.21 , pp. 305-337
    • Basler, C.F.1    Garcia-Sastre, A.2
  • 6
    • 0030851930 scopus 로고    scopus 로고
    • Cell-mediated immunity to porcine reproductive and respiratory syndrome virus in swine
    • Bautista EM, and Molitor TW: Cell-mediated immunity to porcine reproductive and respiratory syndrome virus in swine. Viral Immunol 1997;10:83-94.
    • (1997) Viral Immunol , vol.10 , pp. 83-94
    • Bautista, E.M.1    Molitor, T.W.2
  • 7
    • 0032788693 scopus 로고    scopus 로고
    • IFN gamma inhibits porcine reproductive and respiratory syndrome virus replication in macrophages
    • Bautista EM, and Molitor TW: IFN gamma inhibits porcine reproductive and respiratory syndrome virus replication in macrophages. Arch Virol 1999;144:1191-1200.
    • (1999) Arch Virol , vol.144 , pp. 1191-1200
    • Bautista, E.M.1    Molitor, T.W.2
  • 8
    • 0030221837 scopus 로고    scopus 로고
    • The neglected role of type I interferon in the T-cell response: Implications for its clinical use
    • Belardelli F, and Gresser T: The neglected role of type I interferon in the T-cell response: implications for its clinical use. Immunol Today 1996;17:369-372.
    • (1996) Immunol Today , vol.17 , pp. 369-372
    • Belardelli, F.1    Gresser, T.2
  • 9
    • 38849178091 scopus 로고    scopus 로고
    • Coinfection of pigs with porcine respiratory coronavirus and Bordetella bronchiseptica
    • Brockmeier SL, Loving CL, Nicholson TL, and Palmer MV: Coinfection of pigs with porcine respiratory coronavirus and Bordetella bronchiseptica. Vet Microbiol 2008;128:36-47.
    • (2008) Vet Microbiol , vol.128 , pp. 36-47
    • Brockmeier, S.L.1    Loving, C.L.2    Nicholson, T.L.3    Palmer, M.V.4
  • 10
    • 0031751351 scopus 로고    scopus 로고
    • In vivo and in vitro interferon (IFN) studies with the porcine reproductive and respiratory syndrome virus (PRRSV)
    • Buddaert W, Van Reeth K, and Pensaert M: In vivo and in vitro interferon (IFN) studies with the porcine reproductive and respiratory syndrome virus (PRRSV). Adv Exp Med Biol 1998;440:461-467.
    • (1998) Adv Exp Med Biol , vol.440 , pp. 461-467
    • Buddaert, W.1    Van Reeth, K.2    Pensaert, M.3
  • 11
    • 20444393463 scopus 로고    scopus 로고
    • Reduction of porcine reproductive and respiratory syndrome virus (PRRSV) infection in swine alveolar macrophages by porcine circovirus 2 (PCV2)-induced interferon-alpha
    • Chang HW, Jeng CR, Liu JJ, et al.: Reduction of porcine reproductive and respiratory syndrome virus (PRRSV) infection in swine alveolar macrophages by porcine circovirus 2 (PCV2)-induced interferon-alpha. Vet Microbiol 2005;108:167-177.
    • (2005) Vet Microbiol , vol.108 , pp. 167-177
    • Chang, H.W.1    Jeng, C.R.2    Liu, J.J.3
  • 12
    • 0037063987 scopus 로고    scopus 로고
    • Evaluation of cytokine gene expression in porcine spleen cells, peripheral blood mononuclear cells, and alveolar macrophages by competitive RT-PCR
    • Choi IS, Collisson EW, Maheswaran SK, and Yoo HS: Evaluation of cytokine gene expression in porcine spleen cells, peripheral blood mononuclear cells, and alveolar macrophages by competitive RT-PCR. FEMS Immunol Med Microbiol 2002;34:119-126.
    • (2002) FEMS Immunol Med Microbiol , vol.34 , pp. 119-126
    • Choi, I.S.1    Collisson, E.W.2    Maheswaran, S.K.3    Yoo, H.S.4
  • 13
    • 0029005297 scopus 로고
    • Detection of porcine reproductive and respiratory syndrome virus in boar semen by PCR
    • Christopher-Hennings J, Nelson EA, Nelson JK, et al.: Detection of porcine reproductive and respiratory syndrome virus in boar semen by PCR. J Clin Microbiol 1995;33:1730-1734.
    • (1995) J Clin Microbiol , vol.33 , pp. 1730-1734
    • Christopher-Hennings, J.1    Nelson, E.A.2    Nelson, J.K.3
  • 14
    • 1842639409 scopus 로고    scopus 로고
    • Expression of interferon-alpha and Mx1 protein in pigs acutely infected with porcine reproductive and respiratory syndrome virus (PRRSV)
    • Chung HK, Lee JH, Kim SH, and Chae C: Expression of interferon-alpha and Mx1 protein in pigs acutely infected with porcine reproductive and respiratory syndrome virus (PRRSV). J Comp Pathol 2004;130:299-305.
    • (2004) J Comp Pathol , vol.130 , pp. 299-305
    • Chung, H.K.1    Lee, J.H.2    Kim, S.H.3    Chae, C.4
  • 15
    • 21444433341 scopus 로고    scopus 로고
    • Immune responses of pigs after experimental infection with a European strain of porcine reproductive and respiratory syndrome virus
    • Diaz I, Darwich L, Pappaterra G, Pujols J, and Mateu E: Immune responses of pigs after experimental infection with a European strain of porcine reproductive and respiratory syndrome virus. J Gen Virol 2005;86:1943-51.
    • (2005) J Gen Virol , vol.86 , pp. 1943-1951
    • Diaz, I.1    Darwich, L.2    Pappaterra, G.3    Pujols, J.4    Mateu, E.5
  • 16
    • 0030739090 scopus 로고    scopus 로고
    • Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV)
    • Duan X, Nauwynck HJ, and Pensaert MB: Virus quantification and identification of cellular targets in the lungs and lymphoid tissues of pigs at different time intervals after inoculation with porcine reproductive and respiratory syndrome virus (PRRSV). Vet Microbiol 1997;56:9-19.
    • (1997) Vet Microbiol , vol.56 , pp. 9-19
    • Duan, X.1    Nauwynck, H.J.2    Pensaert, M.B.3
  • 17
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • Gallucci S, Lolkema M, and Matzinger P: Natural adjuvants: endogenous activators of dendritic cells. Nat Med 1999;5:1249-1255.
    • (1999) Nat Med , vol.5 , pp. 1249-1255
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 18
    • 12144288183 scopus 로고    scopus 로고
    • Genomic characterization of virulent, attenuated, and revertant passages of a North American porcine reproductive and respiratory syndrome virus strain
    • Grebennikova TV, Clouser DF, Vorwald AC, et al.: Genomic characterization of virulent, attenuated, and revertant passages of a North American porcine reproductive and respiratory syndrome virus strain. Virology 2004;321:383-390.
    • (2004) Virology , vol.321 , pp. 383-390
    • Grebennikova, T.V.1    Clouser, D.F.2    Vorwald, A.C.3
  • 19
    • 0029678766 scopus 로고    scopus 로고
    • Comparative pathogenicity of nine U.S. porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig model
    • Halbur PG, Paul PS, Meng XJ, Lum MA, Andrews JJ, and Rathje JA: Comparative pathogenicity of nine U.S. porcine reproductive and respiratory syndrome virus (PRRSV) isolates in a five-week-old cesarean-derived, colostrum-deprived pig model. J Vet Diagn Invest 1996;8:11-20.
    • (1996) J Vet Diagn Invest , vol.8 , pp. 11-20
    • Halbur, P.G.1    Paul, P.S.2    Meng, X.J.3    Lum, M.A.4    Andrews, J.J.5    Rathje, J.A.6
  • 20
    • 0030626866 scopus 로고    scopus 로고
    • Temporal and morphologic characterization of the distribution of porcine reproductive and respiratory syndrome virus (PRRSV) by in situ hybridization in pigs infected with isolates of PRRSV that differ in virulence
    • Haynes JS, Halbur PG, Sirinarumitr T, Paul PS, Meng XJ, and Huffman EL: Temporal and morphologic characterization of the distribution of porcine reproductive and respiratory syndrome virus (PRRSV) by in situ hybridization in pigs infected with isolates of PRRSV that differ in virulence. Vet Pathol 1997;34:39-43.
    • (1997) Vet Pathol , vol.34 , pp. 39-43
    • Haynes, J.S.1    Halbur, P.G.2    Sirinarumitr, T.3    Paul, P.S.4    Meng, X.J.5    Huffman, E.L.6
  • 21
    • 7044253008 scopus 로고    scopus 로고
    • Pathogenic and humoral immune responses to porcine reproductive and respiratory syndrome virus (PRRSV) are related to viral load in acute infection
    • Johnson W, Roof M, Vaughn E, Christopher-Hennings J, Johnson CR, and Murtaugh MP: Pathogenic and humoral immune responses to porcine reproductive and respiratory syndrome virus (PRRSV) are related to viral load in acute infection. Vet Immunol Immunopathol 2004;102:233-147.
    • (2004) Vet Immunol Immunopathol , vol.102 , pp. 233-147
    • Johnson, W.1    Roof, M.2    Vaughn, E.3    Christopher-Hennings, J.4    Johnson, C.R.5    Murtaugh, M.P.6
  • 22
    • 0036715591 scopus 로고    scopus 로고
    • Viruses and interferon: A fight for supremacy
    • Katze MG, He Y, and Gale M Jr: Viruses and interferon: a fight for supremacy. Nat Rev Immunol 2002;2:675-687.
    • (2002) Nat Rev Immunol , vol.2 , pp. 675-687
    • Katze, M.G.1    He, Y.2    Gale Jr, M.3
  • 23
    • 0141994737 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus persistence in blood, spleen, lymph nodes, and tonsils of experimentally infected pigs depends on the level of CD8high T cells
    • Lamontagne L, Page C, Larochelle R, and Magar R: Porcine reproductive and respiratory syndrome virus persistence in blood, spleen, lymph nodes, and tonsils of experimentally infected pigs depends on the level of CD8high T cells. Viral Immunol 2003;16:395-406.
    • (2003) Viral Immunol , vol.16 , pp. 395-406
    • Lamontagne, L.1    Page, C.2    Larochelle, R.3    Magar, R.4
  • 24
    • 7044249190 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus field isolates differ in in vitro interferon phenotypes
    • Lee SM. Schommer SK, and Kleiboeker SB: Porcine reproductive and respiratory syndrome virus field isolates differ in in vitro interferon phenotypes. Vet Immunol Immunopathol 2004;102:217-231.
    • (2004) Vet Immunol Immunopathol , vol.102 , pp. 217-231
    • Lee, S.M.1    Schommer, S.K.2    Kleiboeker, S.B.3
  • 25
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001;25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 26
    • 33845410148 scopus 로고    scopus 로고
    • Innate cytokine responses in porcine macrophage populations: Evidence for differential recognition of double-stranded RNA
    • Loving CL, Brockmeier SL, Ma W, Richt JA, and Sacco RE: Innate cytokine responses in porcine macrophage populations: evidence for differential recognition of double-stranded RNA. J Immunol 2006;177:8432-8439.
    • (2006) J Immunol , vol.177 , pp. 8432-8439
    • Loving, C.L.1    Brockmeier, S.L.2    Ma, W.3    Richt, J.A.4    Sacco, R.E.5
  • 27
    • 33845973334 scopus 로고    scopus 로고
    • Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus
    • Loving CL, Brockmeier SL, and Sacco RE: Differential type I interferon activation and susceptibility of dendritic cell populations to porcine arterivirus. Immunology 2007;120:217-229.
    • (2007) Immunology , vol.120 , pp. 217-229
    • Loving, C.L.1    Brockmeier, S.L.2    Sacco, R.E.3
  • 28
    • 0033081259 scopus 로고    scopus 로고
    • Type I interferons keep activated T cells alive
    • Marrack P, Kappler J, and Mitchell T: Type I interferons keep activated T cells alive. J Exp Med 1999;189:521-530.
    • (1999) J Exp Med , vol.189 , pp. 521-530
    • Marrack, P.1    Kappler, J.2    Mitchell, T.3
  • 29
    • 1642422416 scopus 로고    scopus 로고
    • Toll-like receptor 3: A link between toll-like receptor, interferon and viruses
    • Matsumoto M, Funami K, Oshiumi H, and Seya T: Toll-like receptor 3: a link between toll-like receptor, interferon and viruses. Microbiol Immunol 2004;48:147-154.
    • (2004) Microbiol Immunol , vol.48 , pp. 147-154
    • Matsumoto, M.1    Funami, K.2    Oshiumi, H.3    Seya, T.4
  • 30
    • 0242500999 scopus 로고    scopus 로고
    • Gradual development of the interferon-gamma response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination
    • Meier WA, Galeota J, Osorio FA, Husmann RJ, Schnitzlein WM, and Zuckermann FA: Gradual development of the interferon-gamma response of swine to porcine reproductive and respiratory syndrome virus infection or vaccination. Virology 2003;309:18-31.
    • (2003) Virology , vol.309 , pp. 18-31
    • Meier, W.A.1    Galeota, J.2    Osorio, F.A.3    Husmann, R.J.4    Schnitzlein, W.M.5    Zuckermann, F.A.6
  • 31
    • 0032238986 scopus 로고    scopus 로고
    • Clinical consequences of exposing pregnant gilts to strains of porcine reproductive and respiratory syndrome (PRRS) virus isolated from field cases of "atypical" PRRS
    • Mengeling WL, Lager KM, and Vorwald AC: Clinical consequences of exposing pregnant gilts to strains of porcine reproductive and respiratory syndrome (PRRS) virus isolated from field cases of "atypical" PRRS. Am J Vet Res 1998;59:1540-1544.
    • (1998) Am J Vet Res , vol.59 , pp. 1540-1544
    • Mengeling, W.L.1    Lager, K.M.2    Vorwald, A.C.3
  • 32
    • 7044286680 scopus 로고    scopus 로고
    • Interferon type I response in porcine reproductive and respiratory syndrome virus-infected MARC-145 cells
    • Miller LC, Laegreid WW, Bono JL, Chitko-McKown CG, and Fox JM: Interferon type I response in porcine reproductive and respiratory syndrome virus-infected MARC-145 cells. Arch Virol 2004;149:2453-2463.
    • (2004) Arch Virol , vol.149 , pp. 2453-2463
    • Miller, L.C.1    Laegreid, W.W.2    Bono, J.L.3    Chitko-McKown, C.G.4    Fox, J.M.5
  • 33
    • 0027059237 scopus 로고
    • Molecular cloning of porcine Mx cDNAs: New members of a family of interferon-inducible proteins with homology to GTP-binding proteins
    • Muller M, Winnacker EL, and Brem G: Molecular cloning of porcine Mx cDNAs: new members of a family of interferon-inducible proteins with homology to GTP-binding proteins. J Interferon Res 1992;12:119-129.
    • (1992) J Interferon Res , vol.12 , pp. 119-129
    • Muller, M.1    Winnacker, E.L.2    Brem, G.3
  • 34
    • 0036452972 scopus 로고    scopus 로고
    • Immunological responses of swine to porcine reproductive and respiratory syndrome virus infection
    • Murtaugh MP, Xiao Z, and Zuckermann F: Immunological responses of swine to porcine reproductive and respiratory syndrome virus infection. Viral Immunol 2002;15:533-547.
    • (2002) Viral Immunol , vol.15 , pp. 533-547
    • Murtaugh, M.P.1    Xiao, Z.2    Zuckermann, F.3
  • 36
    • 0035096556 scopus 로고    scopus 로고
    • Inhibition of porcine reproductive and respiratory syndrome virus by interferongamma and recovery of virus replication with 2-aminopurine
    • Rowland RR, Robinson B, Stefanick J, Kim TS, Guanghua L, Lawson SR, and Benfield DA: Inhibition of porcine reproductive and respiratory syndrome virus by interferongamma and recovery of virus replication with 2-aminopurine. Arch Virol 2001;146:539-555.
    • (2001) Arch Virol , vol.146 , pp. 539-555
    • Rowland, R.R.1    Robinson, B.2    Stefanick, J.3    Kim, T.S.4    Guanghua, L.5    Lawson, S.R.6    Benfield, D.A.7
  • 38
    • 0034578082 scopus 로고    scopus 로고
    • The role of pulmonary intravascular macrophages in porcine reproductive and respiratory syndrome virus infection
    • Thanawongnuwech R, Halbur PG, and Thacker EL: The role of pulmonary intravascular macrophages in porcine reproductive and respiratory syndrome virus infection. Anim Health Res Rev 2000;1:95-102.
    • (2000) Anim Health Res Rev , vol.1 , pp. 95-102
    • Thanawongnuwech, R.1    Halbur, P.G.2    Thacker, E.L.3
  • 40
    • 0033175579 scopus 로고    scopus 로고
    • Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: Correlations with pathogenicity
    • Van Reeth K, Labarque G, Nauwynck H, and Pensaert M: Differential production of proinflammatory cytokines in the pig lung during different respiratory virus infections: correlations with pathogenicity. Res Vet Sci 1999;67:47-52.
    • (1999) Res Vet Sci , vol.67 , pp. 47-52
    • Van Reeth, K.1    Labarque, G.2    Nauwynck, H.3    Pensaert, M.4
  • 41
    • 11144240264 scopus 로고    scopus 로고
    • Inverse interference: How viruses fight the interferon system
    • Weber F, Kochs G, and Haller O: Inverse interference: how viruses fight the interferon system. Viral Immunol 2004;17:498-515.
    • (2004) Viral Immunol , vol.17 , pp. 498-515
    • Weber, F.1    Kochs, G.2    Haller, O.3
  • 42
    • 33746385915 scopus 로고    scopus 로고
    • Infection with porcine reproductive and respiratory syndrome virus stimulates an early gamma interferon response in the serum of pigs
    • Wesley RD, Lager KM, and Kehrli ME, Jr: Infection with porcine reproductive and respiratory syndrome virus stimulates an early gamma interferon response in the serum of pigs. Can J Vet Res 2006;70:176-182.
    • (2006) Can J Vet Res , vol.70 , pp. 176-182
    • Wesley, R.D.1    Lager, K.M.2    Kehrli Jr, M.E.3
  • 43
    • 0037232194 scopus 로고    scopus 로고
    • Duration of infection and proportion of pigs persistently infected with porcine reproductive and respiratory syndrome virus
    • Wills RW, Doster AR, Galeota JA, Sur JH, and Osorio FA: Duration of infection and proportion of pigs persistently infected with porcine reproductive and respiratory syndrome virus. J Clin Microbiol 2003;41:58-62.
    • (2003) J Clin Microbiol , vol.41 , pp. 58-62
    • Wills, R.W.1    Doster, A.R.2    Galeota, J.A.3    Sur, J.H.4    Osorio, F.A.5
  • 44
    • 0030814740 scopus 로고    scopus 로고
    • Porcine reproductive and respiratory syndrome virus: A persistent infection
    • Wills RW, Zimmerman JJ, Yoon KJ, et al.: Porcine reproductive and respiratory syndrome virus: a persistent infection. Vet Microbiol 1997;55:231-240.
    • (1997) Vet Microbiol , vol.55 , pp. 231-240
    • Wills, R.W.1    Zimmerman, J.J.2    Yoon, K.J.3


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