Dynamic changes in lipids and proteins of maternal, fetal, and pup blood and milk during perinatal development in CD and wistar rats

Toxicological Sciences

Volumn 105, Issue 2, 2008, Pages 260-274

  Mcmullin, Tami S ^a   Lowe, Ezra R ^a   Bartels, Michael J ^a   Marty, Mary Sue ^a  

^a DOW CHEMICAL COMPANY   (United States)

Author keywords

Gestation; Lactation; Lipids; Perinatal; Pharmacokinetics; Pregnancy; Proteins

Indexed keywords

ALBUMIN; GLOBULIN; LIPID; LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; TRIACYLGLYCEROL;

ACCURACY; ALBUMIN BLOOD LEVEL; AMNION FLUID LEVEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; FEMALE; FETUS; FETUS BLOOD; GESTATIONAL AGE; LACTATION; LIPID BLOOD LEVEL; LIPOPHILICITY; LIPOPROTEIN BLOOD LEVEL; MALE; MATERNAL BLOOD; MILK LEVEL; NEWBORN; NONHUMAN; PERINATAL DEVELOPMENT; PERINATAL PERIOD; PHOSPHOLIPID BLOOD LEVEL; PREDICTION; PRENATAL EXPOSURE; PROTEIN BLOOD LEVEL; RAT; TOXICOKINETICS; TRIACYLGLYCEROL BLOOD LEVEL; WISTAR RAT;

AMNIOTIC FLUID; ANIMALS; ANIMALS, NEWBORN; FEMALE; FETAL BLOOD; GESTATIONAL AGE; HUMANS; HYDROGEN-ION CONCENTRATION; LACTATION; LIPIDS; MALE; MILK; MODELS, BIOLOGICAL; PHARMACOKINETICS; PROTEIN BINDING; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SPECIES SPECIFICITY; TIME FACTORS; TOXICITY TESTS;

RATTUS NORVEGICUS; RODENTIA;

EID: 51849104238     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn124     Document Type: Article

References (55)

1. Alvarez, J. J., Montelongo, A., Iglesias, A., Lasuncion, M. A., and Herrera, E. (1996). Longitudinal study on lipoprotein profile, high density lipoprotein subclass, and postheparin lipases during gestation in women. J. Lipid Res. 37, 299-308.
2. Barron, W. M. (1987). Volume homeostasis during pregnancy in the rat. Am. J. Kidney Dis. 9, 296-302.
3. Byczkowski, J. Z., Gearhart, J. M., and Fisher, J. W. (1994). "Occupational" exposure of infants to toxic chemicals via breast milk. Nutrition 10, 43-48.
4. Cooper, R. L., Lamb, J. C., Barlow, S. M., Bentley, K., Brady, A. M., Doerrer, N. G., Eisenbrandt, D. L., Fenner-Crisp, P. A., Hines, R. N., Irvine, L. F., et al. (2006). A tiered approach to life stages testing for agricultural chemical safety assessment. Crit. Rev. Toxicol. 36, 69-98.
5. Corley, R. A., Mast, T. J., Carney, E. W., Rogers, J. M., and Daston, G. P. (2003). Evaluation of physiologically based models of pregnancy and lactation for their application in children's health risk assessments. Crit. Rev. Toxicol. 33, 137-211.
6. Dean, M., Stock, B., Patterson, R. J., and Levy, G. (1980). Serum protein binding of drugs during and after pregnancy in humans. Clin. Pharmacol. Ther. 28, 253-261.
7. Duvekot, J. J., Cheriex, E. C., Pieters, F. A., and Peeters, L. L. H. (1995). Maternal volume homeostasis in early pregnancy in relation to fetal growth restriction. Obstet. Gynecol. 85, 361-367.
8. Ecobichon, D. J. (1984). The perinatal guinea pig as a model for toxicological studies. In Toxicology and the Newborn (S. Kacew and M. J. Reasor, Eds.), pp. 34-65. Elsevier Science Publisher B.V., New York.
9. Food Quality Protection Act. (1996). Legislation enacted by the United States government (P.L. 104-170, formerly known as H. R. 1627).
10. Geursen, A., Carne, A., and Grigor, M. R. (1987). Protein synthesis in mammary acini isolated from lactating rats: Effect of maternal diet. J. Nutr. 117, 769-775.
11. Girard, J. R., Cuendet, G. S., Marliss, E. B., Kervran, A., Rieutort, M., and Assan, R. (1973). Fuels, hormones and liver metabolism at term and during the early postnatal period in the rat. J. Clin. Invest. 52, 3190-3200.
12. Godbole, V. Y., Grundleger, M. L., Pasquine, T. A., and Thenen, S. W. (1981). Composition of rat milk from day 5 to 20 of lactation and milk intake of lean and preobese Zucker pups. J. Nutr. 111, 480-487.
13. Green, M. H., Dohner, E. L., and Green, J. B. (1981). Influence of dietary fat and cholesterol on milk lipids and on cholesterol metabolism in the rat. J. Nutr. 111, 276-286.
14. Grigor, M. R., Poczwa, Z., and Arthur, P. G. (1986). Milk lipid synthesis and secretion during milk stasis in the rat. J. Nutr. 116, 1789-1797.
15. Gugler, R., Shoeman, D. W., Huffman, D. H., Cohlima, J. B., and Azarnoff, D. L. (1975). Pharmacokinetics of drugs in patients with nephrotic syndrome. J. Clin. Invest. 55, 1182-1189.
16. Haddad, S., Poulin, P., and Krishnan, K. (2000). Relative lipid content as the sole mechanistic determinant of the adipose tissue:bLood partition coefficients of highly lipophilic organic chemicals. Chemosphere 40, 839-843.
17. Harris, R. A., MacNintch, J. E., and Quackenbush, F. W. (1966). Mechanism of suckling rat hypercholesterolemia: Dietary and drug studies. J. Nutr. 90, 40-46.
18. Herrera, E., and Lasuncion, M. A. (2004). Lipid metabolism. In Fetal and Neonatal Physiology, 3rd ed. (W. A. Polin, W. W. Fox and S. H. Abman, Eds.), Vol. 1, pp. 375-388. Saunders, Philadelphia, PA.
19. Herrera, E. (2000). Metabolic adaptations in pregnancy and their implications for the availability of substrates to the fetus. Eur. J. Clin. Nutr. 54 (Suppl. 1), S47-S51.
20. Herrera, E. (2002). Implications of dietary fatty acids during pregnancy on placental, fetal and postnatal development - A review. Placenta 23 (Suppl. A),S9-S19.
21. Herrera, E., Lasuncion, M. A., Huerta, L., and Martin-Hidalgo, A. (2000). Plasma leptin levels in rat mother and offspring during pregnancy and lactation. Biol. Neonate 78, 315-320.
22. Keen, C. L., Lonnerdal, B., Clegg, M., and Hurley, L. S. (1981). Developmental changes in composition of rat milk: Trace elements, minerals, protein, carbohydrate and fat. J. Nutr. 111, 226-236.
23. Keen, C. L., Lonnerdal, B., Sloan, M. V., and Hurley, L. S. (1980). Effects of milking procedure on rat milk composition. Physiol. Behav. 24, 613-615.
24. Kimmel, C. A., Kavlock, R. J., and Francis, E. Z. (1992). Animal models for assessing developmental toxicity. In Similarities and Differences between Children and Adults. Implications for Risk Assessment (P. S. Guzelian, C. J. Henry and S. S. Olin, Eds.), pp. 43-65. ILSI Press, Washington, DC.
25. King, J. C. (2000). Physiology of pregnancy and nutrient metabolism. Am. J. Clin. Nutr. 71, 1218S-25S.
26. Knopp, R. H., Herrera, E., and Freinkel, N. (1970). Carbohydrate metabolism in pregnancy. 8. Metabolism of adipose tissue isolated from fed and fasted pregnant rats during late gestation. J. Clin. Invest. 49, 1438-1446.
27. Krauer, B. (1987). Physiological changes and drug disposition during pregnancy. In Pharmacokinetics in Teratogenesis (H. Nau, W. J. Scott, Jr, Eds.), pp. 3-12. CRC Press, Boca Raton.
28. Kulski, J. K., and Hartmann, P. E. (1981). Changes in human milk composition during the initiation of lactation. Aust. J. Exp. Biol. Med. Sci. 59, 101-114.
29. LaBorde, J. B., Wall, K. S., Bolon, B., Kumpe, T. S., Patton, R., Zheng, Q., Kodell, R., and Young, J. F. (1999). Haematology and serum chemistry parameters of the pregnant rat. Lab. Anim. 33, 275-287.
30. LaKind, J. S., Wilkins, A. A., and Berlin, C. M., Jr. (2004). Environmental chemicals in human milk: A review of levels, infant exposures and health, and guidance for future research. Toxicol. Appl. Pharmacol. 198, 184-208.
31. Lee, S. K. (2005). Perinatal pharmacokinetics. In Physiologically based Pharmacokinetic Modeling Science and Applications (M. B. Reddy, R. S. H. Yang, H. J. Clewell and M. E. Andersen, Eds.), pp. 321-346. John Wiley & Sons, Inc, Hoboken, NJ.
32. Levy, G. (1976). Effect of plasma protein binding of drugs on duration and intensity of pharmacological activity. J. Pharm. Sci. 65 1264-1265.
33. Liberati, T. A., Sansone, S. R., and Feuston, M. H. (2004). Hematology and clinical chemistry values in pregnant Wistar Hannover rats compared with nonmated controls. Vet. Clin. Pathol. 33, 68-73.
34. Lin, Y.-S., Smith, T. J., Wypij, D., Kelsey, K. T., and Sacks, F. M. (2002). Association of the blood/air partition coefficient of 1,3-butadiene with blood lipids and albumin. Environ. Health Perspect. 110, 165-168.
35. Long, C. (1961). Chemical composition of animal tissues and related data. In The Biochemists' Handbook (C. Long, E. King and S. W.M, Eds.), Vol. 1, pp. 839-936. D. Van Nostrand Company, Inc., Princeton, NJ.
36. Lonnerdal, B., Forsum, E., and Hambraeus, L. (1976). A longitudinal study of the protein, nitrogen, and lactose contents of human milk from Swedish well-nourished mothers. Am. J. Clin. Nutr. 29, 1127-1133.
37. Lopez-Luna, P., Munoz, T., and Herrera, E. (1986). Body fat in pregnant rats at mid- and late-gestation. Life Sci. 39, 1389-1393.
38. Marty, M. S., Rick, D. L., Grundy, J. M., Bartels, M. J., and Mattson, J. L. (2006). Biomonitoring implications of chlorpyrifos (CPF) blood partitioning during gestation and lactation. Toxicologist 90 (S-1), 254-255.
39. Mattsson, J. L., Maurissen, J. P. J., Nolan, R. J., and Brzak, K. A. (2000). Lack of differential sensitivity to cholinesterase inhibition in fetuses and neonates compared to dams treated perinatally with chlorpyrifos. Toxicol. Sci. 53, 438-446.
40. Montelongo, A., Lasuncion, M. A., Pallardo, L. F., and Herrera, E. (1992). Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women. Diabetes 41, 1651-1659.
41. Nicholas, K. R., and Hartmann, P. E. (1991). Milk secretion in the rat: Progressive changes in milk composition during lactation and weaning and the effect of diet. Comp. Biochem. Physiol. A 98, 535-542.
42. O'Flaherty, E. J., Scott, W., Schreiner, C., and Beliles, R. P. (1992). A physiologically based kinetic model of rat and mouse gestation: Disposition of a weak acid. Toxicol. Appl. Pharmacol. 112, 245-256.
43. Olanoff, L. S., and Anderson, J. M. (1980). Controlled release of tetracycline-III: A physiological pharmacokinetic, model of the pregnant rat. J. Pharmacokinet. Biopharm. 8, 599-620.
44. Papworth, T. A., and Clubb, S. K. (1995). Clinical pathology in the neonatal rat. Comp. Haematol. Int. 5, 237-250.
45. Poulin, P., and Krishnan, K. (1995). An algorithm for predicting tissue: Blood partitioning of organic chemicals from n-octanol: Water partition coefficient data. J. Toxicol. Environ. Health 46, 117-129.
46. Poulin, P., and Theil, F.-P. (1995). A priori prediction of tissue: Plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery. J. Pharm. Sci. 89, 16-35.
47. Safe Drinking Water Act. (1996). Legislation enacted by the United States government in 1974 and amended in 1986 and 1996 (P.L. 104-182).
48. Saghir, S. A., Mendrala, A. L., Bartels, M. J., Day, S. J., Hansen, S. C., Sushynski, J. M., and Bus, J. S. (2006). Strategies to assess systemic exposure to chemicals in subchronic/chronic diet and drinking water studies. Toxicol. Appl. Pharmacol. 211, 245-260.
49. Stock, B., Dean, M., and Levy, G. (1980). Serum protein binding of drugs during and after pregnancy in rats. J. Pharmacol. Exp. Ther. 212, 264-268.
50. Vidair, C. A. (2004). Age dependence of organophosphate and carbamate neurotoxicity in the postnatal rat: Extrapolation to the human. Toxicol. Appl. Pharmacol. 196, 287-302.
51. Vodicnik, M. J., and Lech, J. J. (1980). The transfer of 2,4,5,2′,4′,5′- hexachlorobiphenyl to fetuses and nursing offspring. I. Disposition in pregnant and lactating mice and accumulation in young. Toxicol. Appl. Pharmacol. 54, 293-300.
52. Watson, R. E., DeSesso, J. M., Hurtt, M. E., and Capon, G. D. (2006). Postnatal growth and morphological development of the brain: A species comparison. Birth Defects Res. B 77, 471-484.
53. Wixom, S. K., and Smiler, K. L. (1997). Anesthesia and analgesia in rodents. In Anesthesia and Analgesia in Laboratory Animals (D. F. Kohn, Ed.), pp. 190. Academic Press, New York.
54. Zoetis, T., and Hurtt, M. E. (2003a). Species comparison of anatomical and functional renal development. Birth Defects Res. B 68, 111-120.
55. Zoetis, T., and Hurtt, M. E. (2003b). Species comparison of lung development. Birth Defects Res. B 68, 121-124.