Maternal-Fetal Transfer of Lipid Metabolites

Fetal and Neonatal Physiology: Third Edition

Volumn 1-2, Issue , 2003, Pages 375-388

  Herrera, Emilio ^a   Lasunción, Miguel Angel ^b,c  

^a UNIVERSIDAD SAN PABLO CEU   (Spain)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 51849120925     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-7216-9654-6.50042-4     Document Type: Chapter

References (232)

1. Boyd EM The lipemia of pregnancy. J Clin Invest 1934, 13:347.
2. Peters JP, et al. The lipids of serum in pregnancy. J Clin Invest 1951, 30:388.
3. Montelongo A, et al. Longitudinal study of plasma lipoproteins and hormones during pregnancy in normal and diabetic women. Diabetes 1992, 41:1651.
4. Knopp RH, et al. Lipoprotein metabolism in pregnancy. Perinatal Biochemistry 1992, 19-51. CRC Press, Boca Raton. E. Herrera, R.H. Knopp (Eds.).
5. Montes A, et al. Physiologic and supraphysiologic increases in lipoprotein lipids and apoproteins in late pregnancy and postpartum: possible markers for the diagnosis of "prelipemia.". Arteriosclerosis 1984, 4:407.
6. Fahraeus L, et al. Plasma lipoproteins including high density lipoprotein subfractions during normal pregnancy. Obstet Gynecol 1985, 66:468.
7. Alvarez JJ, et al. Longitudinal study on lipoprotein profile, high density lipoprotein subclass, and postheparin lipases during gestation in women. J Lipid Res 1996, 37:299.
8. Elliott JA The effect of pregnancy on the control of lipolysis in fat cells isolated from human adipose tissue. Eur J Clin Invest 1975, 5:159.
9. Knopp RH, et al. Carbohydrate metabolism in pregnancy: VIII. metabolism of adipose tissue isolated from fed and fasted pregnant rats during late gestation. J Clin Invest 1970, 49:1438.
10. Chaves JM, Herrera E In vitro response of glycerol metabolism to insulin and adrenaline in adipose tissue from fed and fasted rat during pregnancy. Biol Neonate 1980, 38:139.
11. Ramos P, Herrera E Reversion of insulin resistance in the rat during late pregnancy by 72-h glucose infusion. Am J Physiol Endocrinol Metab 1995, 269:E858.
12. Weinstein I, et al. Effects of ethynylestradiol on metabolism of (1-14C)-oleate by perfused livers and hepatocytes from female rats. Biochem J 1979, 180:265.
13. Kinnunen PK, et al. Activities of post-heparin plasma lipoprotein lipase and hepatic lipase during pregnancy and lactation. Eur J Clin Invest 1980, 10:469.
14. Herrera E, et al. Serum lipid profile in diabetic pregnancy. Adv Diabet 1992, 5(Suppl 1):73.
15. Otway S, Robinson DS The significance of changes in tissue clearing-factor lipase activity in relation to the lipaemia of pregnancy. Biochem J 1968, 106:677.
16. Herrera E, et al. Role of lipoprotein lipase activity on lipoprotein metabolism and the fate of circulating triglycerides in pregnancy. Am J Obstet Gynecol 1988, 158:1575.
17. Martin-Hidalgo A, et al. Lipoprotein lipase and hormone-sensitive lipase activity and mRNA in rat adipose tissue during pregnancy. Am J Physiol 1994, 266:E930.
18. Ramos P, Herrera E Comparative responsiveness to prolonged hyperinsulinemia between adipose tissue and mammary gland lipoprotein lipase activities in pregnant rats. Early Pregnancy Biol Med 1996, 2:29.
19. Hamosh M, et al. Lipoprotein lipase activity of adipose and mammary tissue and plasma triglyceride in pregnant and lactating rats. Biochim Biophys Acta 1970, 210:473.
20. Herrera E, et al. Control by insulin of adipose tissue lipoprotein lipase activity during late pregnancy in the rat. Frontiers in Diabetes Research: Lessons from Animal Diabetes III 1990, 551-554. Smith-Gordon, London. E. Shafrir (Ed.).
21. Iglesias A, et al. Changes in cholesteryl ester transfer protein activity during normal gestation and postpartum. Clin Biochem 1994, 27:63.
22. Applebaum-Bowden D, et al. Lipoprotein, apolipoprotein, and lipolytic enzyme changes following estrogen administration in postmenopausal women. J Lipid Res 1989, 30:1895.
23. Peinado-Onsurbe J, et al. Effects of sex steroids on hepatic and lipoprotein lipase activity and mRNA in the rat. Horm Res 1993, 40:184.
24. Brinton EA Oral estrogen replacement therapy in postmenopausal women selectively raises levels and production rates of lipoprotein A-I and lowers hepatic lipase activity without lowering the fractional catabolic rate. Arterioscler Thromb Vasc Biol 1996, 16:431.
25. Hrab RV, et al. Prevention of fluvastatin-induced toxicity, mortality, and cardiac myopathy in pregnant rats by mevalonic acid supplementation. Teratology 1994, 50:19.
26. Soria A, et al. Opposite metabolic response to fenofibrate treatment in pregnant and virgin rats. J Lipid Res 2002, 43:74.
27. Winkel CA, et al. Uptake and degradation of lipoproteins by human trophoblastic cells in primary culture. Endocrinology 1980, 107:1892.
28. Albrecht ED, et al. Developmental increase in low density lipoprotein receptor messenger ribonucleic acid levels in placental syncytiotrophoblasts during baboon pregnancy. Endocrinology 1995, 136:5540.
29. Winkel CA, et al. Regulation of cholesterol and progesterone synthesis in human placental cells in culture by serum lipoproteins. Endocrinology 1980, 106:1054.
30. Alsat E, et al. Low-density lipoprotein binding sites in the microvillous membranes of human placenta at different stages of gestation. Mol Cell Endocrinol 1984, 38:197.
31. Alsat E, et al. Characterization of specific low-density lipoprotein binding sites in human term placental microvillous membranes. Mol Cell Endocrinol 1982, 28:439.
32. Winkel CA, et al. Regulation of cholesterol metabolism by human trophoblastic cells in primary culture. Endocrinology 1981, 109:1084.
33. Henson MC, et al. Developmental increase in placental low density lipoprotein uptake during baboon pregnancy. Endocrinology 1992, 130:1698.
34. Cummings SW, et al. The binding of high and low density lipoproteins to human placental membrane fractions. J Clin Endocrinol Metab 1982, 54:903.
35. Furuhashi M, et al. Expression of low density lipoprotein receptor gene in human placenta during pregnancy. Mol Endocrinol 1989, 3:1252.
36. Malassine A, et al. Ultrastructural visualization of the internalization of low density lipoprotein by human placental cells. Histochemistry 1987, 87:457.
37. Overbergh L, et al. Expression of mouse alpha-macroglobulins, lipoprotein receptor-related protein, LDL receptor, apolipoprotein E, and lipoprotein lipase in pregnancy. J Lipid Res 1995, 36:1774.
38. Bonet B, et al. Metabolism of very-low-density lipoprotein triglyceride by human placental cells: the role of lipoprotein lipase. Metabolism 1992, 41:596.
39. Elphick MC, Hull D Rabbit placental clearing-factor lipase and transfer to the foetus of fatty acids derived from triglycerides injected into the mother. J Physiol (Lond) 1977, 273:475.
40. Rotherwell JE, Elphick MC Lipoprotein lipase activity in human and guinea pig placenta. J Dev Physiol 1982, 4:153.
41. Thomas CR, Lowy C The clearance and placental transfer of FFA and triglycerides in the pregnant guinea-pig. J Dev Physiol 1982, 4:163.
42. Clegg RA Placental lipoprotein lipase activity in the rabbit, rat and sheep. Comp Biochem Physiol 1981, 69B:585.
43. Farrugia W, et al. Type II phospholipase A2 in human gestational tissues: Subcellular distribution of placental imuno- and catalytic activity. Biochim Biophys Acta 1993, 1166:77.
44. 2 enzymatic activity in human term placenta. J Endocrinol 1998, 157:25.
45. Biale Y Lipolytic activity in the placentas of chronically deprived fetuses. Acta Obstet Gynecol Scand 1985, 64:111.
46. Kaminsky S, et al. Effects of maternal undernutrition and uterine artery ligation on placental lipase activities in the rat. Biol Neonate 1991, 60:201.
47. Mochizuki M, et al. Lipolytic action of human chorionic somatomammotropin. Endocrinol Jpn 1975, 22:123.
48. Coleman RA, Haynes EB Synthesis and release of fatty acids by human trophoblast cells in culture. J Lipid Res 1987, 28:1335.
49. 2, and alpha-fetoprotein concentrations at the human feto-maternal interface. J Lipid Res 1997, 38:276.
50. Benassayag C, et al. High affinity of nonesterified polyunsaturated fatty acids for rat alpha-fetoprotein (AFP). Oncodev Biol Med 1980, 1:27.
51. Parmelee DC, et al. The presence of fatty acids in human α-fetoprotein. J Biol Chem 1978, 253:2114.
52. Berghaus TM, et al. Essential fatty acids and their long-chain polyunsaturated metabolites in maternal and cord plasma triglycerides during late gestation. Biol Neonate 2000, 77:96.
53. Herrera E Implications of dietary fatty acids during pregnancy on placental, fetal and postnatal development. Placenta (Suppl A, Trophoblast Research) 2002, 16:59.
54. Kitajima M, et al. Maternal serum triglyceride at 24-32 weeks' gestation and newborn weight in nondiabetic women with positive diabetic screens. Obstet Gynecol 2001, 97:776.
55. Knopp RH, et al. Prediction of infant birth weight by GDM screening tests: Importance of plasma triglycerides. Diabetes Care 1992, 15:1605.
56. Skryten A, et al. Studies in diabetic pregnancy. I. Serum lipids. Acta Obstet Gynecol Scand 1976, 55:215.
57. Hytten FE, Leitch I The Physiology of Human Pregnancy 1971, Blackwell Scientific, Oxford.
58. Beaton GH, et al. Protein metabolism in the pregnant rat. J Nutr 1954, 54:291.
59. Lopez Luna P, et al. Carcass and tissue fat content in the pregnant rat. Biol Neonate 1991, 60:29.
60. King JC, et al. Energy metabolism during pregnancy: Influence of maternal energy status. Am J Clin Nutr 1994, 59(Suppl):439S.
61. Ludeña MC, et al. Effects of alcohol ingestion in the pregnant rat on daily food intake, offspring growth and metabolic parameters. Gen Pharmacol 1983, 14:327.
62. Palacin M, et al. Circulating metabolite utilization by periuterine adipose tissue in situ in the pregnant rat. Metabolism 1991, 40:534.
63. Knopp RH, et al. Lipid metabolism in pregnancy: II. Postheparin lipolytic activity and hypertriglyceridemia in the pregnant rat. Metabolism 1975, 24:481.
64. López-Luna P, et al. Body fat in pregnant rats at mid- and late-gestation. Life Sci 1986, 39:1389.
65. Freinkel N Metabolic changes in pregnancy. Textbook of Endocrinology 1985, 438-451. WB Saunders Co, Philadelphia. J.D. Wilson, D.W. Foster (Eds.).
66. Chaves JM, Herrera E In vitro glycerol metabolism in adipose tissue from fasted pregnant rats. Biochem Biophys Res Commun 1978, 85:1299.
67. Herrera E, et al. Lipid metabolism in pregnancy. Biol Neonate 1987, 51:70.
68. Humphrey JL, et al. Lipid metabolism in pregnancy: VII. Kinetics of chylomicron triglyceride removal in the fed pregnant rat. Am J Physiol 1980, 239:E81.
69. 14C]oleate in pregnancy. Biochim Biophys Acta 1980, 619:471.
70. 14C-tripalmitate administration in the late pregnant rat. Metabolism 1989, 38:104.
71. Stemberg L, et al. Serum proteins in parturient mother and newborn: an electrophoretic study. Can Med Assoc J 1956, 74:49.
72. Argilés J, Herrera E Lipids and lipoproteins in maternal and fetus plasma in the rat. Biol Neonate 1981, 39:37.
73. Herrera E, et al. Carbohydrate metabolism in pregnancy: VI. plasma fuels, insulin, liver composition, gluconeogenesis and nitrogen metabolism during gestation in the fed and fasted rat. J Clin Invest 1969, 48:2260.
74. Rémésy C, Demigné C Adaptation of hepatic gluconeogenesis and ketogenesis to altered supply of substrates during late pregnancy in the rat. J Dev Physiol 1966, 8:195.
75. Chaves JM, Herrera E In vivo glycerol metabolism in the pregnant rat. Biol Neonate 1980, 37:172.
76. Zorzano A, et al. Role of the availability of substrates on hepatic and renal gluconeogenesis in the fasted late pregnant rat. Metabolism 1986, 35:297.
77. Ramirez I, et al. Circulating triacylglycerols, lipoproteins, and tissue lipoprotein lipase activities in rat mothers and offspring during the perinatal period: effect of postmaturity. Metabolism 1983, 32:333.
78. Carrascosa JM, et al. Changes in the kinase activity of the insulin receptor account for an increased insulin sensitivity of mammary gland in late pregnancy. Endocrinology 1998, 139:520.
79. Scow RO, et al. Hyperlipemia and ketosis in the pregnant rat. Am J Physiol 1964, 206:796.
80. Scow RO, et al. Ketosis in the rat fetus. Proc Soc Exp Biol Med 1958, 98:833.
81. Girard J, et al. Fetal metabolic response to maternal fasting in the rat. Am J Physiol 1977, 232:E456.
82. Testar X, et al. Increase with starvation in the pregnant rat of the liver lipoprotein lipase. Biochem Soc Trans 1985, 13:134.
83. Vilaró S, et al. Lipoprotein lipase activity in the liver of starved pregnant rats. Biol Neonate 1990, 57:37.
84. Carlson MG, et al. Fuel and energy metabolism in fasting humans. Am J Clin Nutr 1994, 60:29.
85. Vazquez JA, Kazi U Lipolysis and gluconeogenesis from glycerol during weight reduction with very-low-calorie diets. Metabolism 1994, 43:1293.
86. Palacin M, et al. Transporte de metabolitos a través de la placenta. Rev Esp Pediatr 1984, 40:163.
87. Munro HN, et al. The placenta in nutrition. Rev Nutr 1983, 3:97.
88. Yudilevich DL, Seeiry JH Transport of amino acids in the placenta. Biochim Biophys Acta 1980, 822:169.
89. Hill EP, Longo LD Dynamics of maternal-fetal nutrient transfer. Fed Proc 1980, 39:239.
90. Baur R Morphometric data and questions concerning placental transfer. Placental Transfer Methods and Interpretations, Placenta Suppl 2 1981, 35-44. WB Saunders Co, London. M. Young (Ed.).
91. Morris FHJ Placental factors conditioning fetal nutrition and growth. Am J Clin Nutr 1981, 34:760.
92. Burr GO, Burr MM On the nature and role of the fatty acids essential in nutrition. J Biol Chem 1929, 82:345.
93. Hassam AG, Crawford MA The differential incorporation of labelled linoleic, T-linolenic, dihomo-T-linolenic and arachidonic acids into the developing brain. J Neurochem 1976, 27:967.
94. Hull D Total fat metabolism. Fetal Physiology and Medicine 1976, 105-120. WB Saunders Co, London. R.W. Beard, G. Nathaniels (Eds.).
95. Widdowson EM Chemical composition of newly born mammals. Nature (Lond) 1950, 166:626.
96. James E, et al. A-V differences of FFA and glycerol in the ovine umbilical circulation. Proc Soc Exp Biol Med 1971, 138:823.
97. Hull D, Stammers JP Placental transfer of fatty acids. Biochem Soc Trans 1985, 13:821.
98. Elphick MC, et al. The transfer of fatty acids across the sheep placenta. J Dev Physiol 1979, 1:31.
99. Leat WMF, Harrison FA Transfer of long chain fatty acids to the fetal and neonatal lamb. J Dev Physiol 1980, 2:257.
100. Hull D, Elphick MC Transfer of fatty acids across the cat placenta. Biol Neonate 1984, 45:15.
101. Elphick MC, et al. Transfer of fatty acids across the rabbit placenta. J Physiol (Lond) 1975, 252:29.
102. Hershfield MS, Nemeth AM Placental transport of free palmitic and linoleic acids in the guinea pig. J Lipid Res 1968, 9:460.
103. Bohmer T, Havel RJ Genesis of fatty liver and hyperlipemia in the fetal guinea pig. J Lipid Res 1975, 16:454.
104. Portman OW, et al. Transfer of free fatty acid across the primate placenta. Am J Physiol 1969, 216:143.
105. Koren Z, Shafrir W Placental transfer of FFA in the pregnant rat. Proc Soc Exp Biol Med 1964, 116:411.
106. 14C-1-palmitate in fetal rats. Biol Neonate 1974, 24:298.
107. Jones CT Lipid metabolism and mobilization in the guinea pig during pregnancy. Biochem J 1976, 156:357.
108. Stammers JP, et al. Effect of maternal diet during late pregnancy on fetal lipid stores in rabbits. J Dev Physiol 1983, 5:395.
109. Amusquivar E, et al. Low arachidonic acid rather than α-tocopherol is responsible for the delayed postnatal development in offspring of rats fed fish oil instead of olive oil during pregnancy and lactation. J Nutr 2000, 130:2855.
110. Coleman RA The role of the placenta in lipid metabolism and transport. Semin Perinatol 1989, 13:180.
111. Kuhn DC, Crawford M Placental essential fatty acid transport and prostaglandin synthesis. Prog Lipid Res 1986, 25:345.
112. Abumrad NA, et al. Permeation of long-chain fatty acids into adipocytes. J Biol Chem 1984, 259:8945.
113. Goresky CA, et al. The capillary transport system for free fatty acids in the heart. Circ Res 1994, 74:1015.
114. Campbell FM, et al. Preferential uptake of long chain polyunsaturated fatty acids by isolated human placental membranes. Mol Cell Biochem 1996, 155:77.
115. Campbell FM, et al. Plasma membrane fatty acid binding protein from human placenta: identification and characterization. Biochem Biophys Res Commun 2000, 209:1011.
116. Campbell FM, et al. Uptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells: role of plasma membrane fatty acid binding protein. J Lipid Res 1997, 38:2558-2568.
117. Haggarty P, et al. Long-chain polyunsaturated fatty acid transport across the perfused human placenta. Placenta 1997, 18:635.
118. Lafond J, et al. Implication of ATP and sodium in arachidonic acid incorporation by placental syncytiotrophoblast brush border and basal plasma membranes in the human. Placenta 2000, 21:661.
119. Shand JH, Noble RC Incorporation of linoleic and arachidonic acids into ovine placental phospholipids in vitro. Biol Neonate 1985, 48:299.
120. Robertson A, et al. Oxidation of palmitate by human placental tissue slices. Phys Chem Physiol 1971, 3:293.
121. Zimmermann T, et al. Oxidation and synthesis of fatty acids in human and rat placental and fetal tissues. Biol Neonate 1979, 36:109.
122. Robertson A, Sprecher H Human placental lipid metabolism. III. Synthesis and hydrolysis of phospholipids. Lipids 1967, 2:403.
123. Tulenko TN, Rabinowitz JL Fatty acid metabolism in human fetal placental vasculature. Am J Physiol 1981, 240:E65.
124. Crawford MA, et al. Essential fatty acids and fetal brain growth. Lancet 1976, 1:452.
125. Innis SM Essential fatty acids in growth and development. Prog Lipid Res 1991, 30:39.
126. Simopoulos AP Ω-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 1991, 54:438.
127. Uauy R, Mena P, Wegher B, et al. Long chain polyunsaturated fatty acid formation in neonates: effect of gestational age and intrauterine growth. Pediatr Res 2000, 47:127.
128. Thomas CR, Lowy C Placental transfer of FFA: factors affecting transfer across the guinea-pig placenta. J Dev Physiol 1983, 5:323.
129. Stephenson TJ, et al. Maternal to fetal transfer of FFA in the "in situ" perfused rabbit placenta. J Dev Physiol 1990, 13:117.
130. Stepien M, et al. Effects of altering umbilical flow and umbilical free fatty acid concentration on transfer of FFA across the rabbit placenta. J Dev Physiol 1991, 15:221.
131. Edson JL, et al. Evidence for increased fatty acid transfer across the placenta during a maternal fast in rabbits. Biol Neonate 1975, 27:50.
132. Stephenson T, et al. Placental transfer of FFA: importance of fetal albumin concentration and acid-base status. Biol Neonate 1993, 63:273.
133. Dancis J, et al. Transfer across perfused human placenta: IV. effect of protein binding on free fatty acids. Pediatr Res 1976, 10:5.
134. Cartlidge PHT, Rutter N Serum albumin concentrations and oedema in the newborn. Arch Dis Child 1986, 61:657.
135. Lasunción MA, et al. Method for the study of metabolite transfer from rat mother to fetus. Biol Neonate 1983, 44:85.
136. Palacin M, et al. Placental formation of lactate from transferred L-alanine and its impairment by aminooxyacetate in the late-pregnant rat. Biochim Biophys Acta 1985, 841:90.
137. Herrera E, et al. Relationship between maternal and fetal fuels and placental glucose transfer in rats with maternal diabetes of varying severity. Diabetes 1985, 34(Suppl 2):42.
138. Palacin M, et al. Decreased uterine blood flow in the diabetic pregnant rat does not modify the augmented glucose transfer to the fetus. Biol Neonate 1985, 48:197.
139. Lasunción MA, et al. Maternal factors modulating nutrient transfer to fetus. Biol Neonate 1987, 51:86.
140. 14C-palmitic acid into placental and fetal liver lipids of the rabbit. Biol Neonate 1977, 32:24.
141. Thomas CR Placental transfer of non-esterified fatty acids in normal and diabetic pregnancy. Biol Neonate 1987, 51:94.
142. Coleman RA Placental metabolism and transport of lipid. Fed Proc 1986, 45:2519.
143. Hummel L, et al. Maternal plasma triglycerides as a source of fetal fatty acids. Acta Biol Med Ger 1976, 35:1635.
144. Thomas CR, Lowy C The interrelationships between circulating maternal esterified and non-esterified fatty acids in pregnant guinea pigs, and their relative contributions to the fetal circulation. J Dev Physiol 1987, 9:203.
145. Elphick MC, et al. The passage of fat emulsion across the human placenta. Br J Obstet Gynaecol 1978, 85:610.
146. Seeds AE, et al. Comparison of human and sheep chorion leave permeability to glucose, beta-hydroxybutyrate and glycerol. Am J Obstet Gynecol 1980, 138:604.
147. Sabata V, et al. The role of FFA, glycerol, ketone bodies and glucose in the energy metabolism of the mother and fetus during delivery. Biol Neonate 1968, 13:7.
148. Gilbert M Origin and metabolic fate of plasma glycerol in the rat and rabbit fetus. Pediatr Res 1977, 11:95.
149. Palacin M, et al. Lactate production and absence of gluconeogenesis from placental transferred substrates in fetuses from fed and 48-H starved rats. Pediatr Res 1987, 22:6.
150. Battaglia FC, Meschia C Principal substrates of fetal metabolism. Physiol Rev 1978, 58:499.
151. Herrera E, et al. Carbohydrate-lipid interactions during gestation and their control by insulin. Braz J Med Biol Res 1994, 27:2499.
152. Bissonette JM Studies "in vivo" of glucose transfer across the guinea-pig placenta. Placenta 1981, 2(Suppl):155.
153. Mampel T, et al. Changes in circulating glycerol, FFA and glucose levels following liver transplant in the pig. Arch Int Physiol Biochim 1981, 89:195.
154. Mampel T, et al. Hepatectomy-nephrectomy effects in the pregnant rat and fetus. Biochem Biophys Res Commun 1985, 131:1219.
155. Mackay EM, Barnes RH Fasting ketosis in the pregnant rat as influenced by adrenalectomy. Proc Soc Exp Biol Med 1936, 34:683.
156. Morris FH, et al. Umbilical V-A differences of acetoacetate and beta hydroxybutyrate in fed and starved ewes. Proc Soc Exp Biol Med 1974, 145:879.
157. Kim YJ, Felig P Maternal and amniotic fluid substrate levels during caloric deprivation in human pregnancy. Metabolism 1971, 21:507.
158. Felig P, Lynch V Starvation in human pregnancy: hypoglycemia, hypoinsulinemia, and hyperketonemia. Science 1970, 170:990.
159. Williamson DH Regulation of the utilization of glucose and ketone bodies by brain in the perinatal period. Early Diabetes in Early Life 1975, 195-202. Academic Press, New York. R.A. Camerini-Davalos, H.S. Cole (Eds.).
160. Persson B, Lunell NO Metabolic control of diabetic pregnancy: variations in plasma concentrations of glucose, FFA, glycerol, ketone bodies, insulin and human chorionic somato-mammotropin during the last trimester. Am J Obstet Gynecol 1975, 122:737.
161. Butte NF Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus. Am J Clin Nutr 2000, 71(Suppl):1256S.
162. Page MA, Williamson DH Enzymes of ketone-body utilisation in human brain. Lancet 1971, 2:66.
163. Shambaugh GE, et al. Fetal fuels: III. Ketone utilization by fetal hepatocyte. Am J Physiol 1978, 235:E330.
164. Adam PAJ, et al. Oxidation of glucose and D-hydroxybutyrate by the early human fetal brain. Acta Paediatr Scand 1975, 64:17.
165. Shambaugh GE, et al. Nutrient metabolism and fetal brain development. Perinatal Biochemistry 1992, 213-231. CRC Press, Boca Raton. E. Herrera, R.H. Knopp (Eds.).
166. Drew JH, et al. Congenital malformations, abnormal glucose tolerance, and estriol excretion in pregnancy. Obstet Gynecol 1978, 51:129.
167. Churchill JA, et al. Neuropsychological deficits in children of diabetic mothers. Am J Obstet Gynecol 1969, 105:257.
168. Miodovnik M, et al. Effect of maternal ketoacidemia on the pregnant ewe and the fetus. Am J Obstet Gynecol 1982, 144:585.
169. Paterson P, et al. Maternal and fetal ketone concentrations in plasma and urine. Lancet 1967, 1:862.
170. Smith AL, Scanlon J Amniotic fluid D(-)β-hydroxybutyrate and the dysmature newborn infant. Am J Obstet Gynecol 1973, 115:569.
171. Arola L, et al. Effects of 24 hour starvation on plasma composition in 19 and 21 day pregnant rats and their foetuses. Horm Metabol Res 1982, 14:364.
172. Lee LPK, Fritz IB Hepatic ketogenesis during development. Can J Biochem 1971, 49:599.
173. Alonso de la Torre SR, et al. Carrier-mediated β-D-hydroxybutyrate transport in brush-border membrane vesicles from rat placenta. Pediatr Res 1992, 32:317.
174. Boyd RD, et al. Growth of glucose and oxygen uptakes by fetuses of fed and starved ewes. Am J Physiol 1973, 225:897.
175. Patel MS, et al. The metabolism of ketone bodies in developing human brain: development of ketone-body utilizing enzymes and ketone bodies as precursors for lipid synthesis. J Neurochem 1975, 25:905.
176. Williamson DH Ketone body metabolism and the fetus. Fetal Growth Retardation 1981, 29-34. Churchill Livingstone, Edinburgh. F.A. Van Assche (Ed.).
177. Seccombe DW, et al. Fetal utilization of maternally derived ketone bodies for lipogenesis in the rat. Biochim Biophys Acta 1977, 438:402.
178. Thaler MM Effects of starvation on normal development of beta-hydroxybutyrate dehydrogenase activity in fetal and newborn rat brain. Nature New Biol 1972, 236:140.
179. Dierks-Ventling C Prenatal induction of ketone-body enzymes in the rat. Biol Neonate 1971, 19:426.
180. Ohvo-Rekilä H, et al. Cholesterol interactions with phospholipids in membranes. Prog Lipid Res 2002, 41:66.
181. Brown MS, Goldstein JL The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997, 89:331.
182. Schroepfer GJ Oxysterols: modulators of cholesterol metabolism and other processes. Physiol Rev 2000, 80:361.
183. Peet DJ, et al. The LXRs: a new class of oxysterol receptors. Curr Opin Genet Dev 1998, 8:571.
184. cdc2 kinase activity and arrests the cell cycle at G2. FASEB J 1999, 13:1359.
185. Suárez Y, et al. Differential effects of ergosterol and cholesterol on Cdk1 activation and SRE-driven transcription: Sterol specificity for cell cycle progression in human cells. Eur J Biochem 2002, 269:1761.
186. Mauch DH, et al. CNS synaptogenesis promoted by glia-derived cholesterol. Science 2001, 294:1354.
187. Roux C, et al. Role of cholesterol in embryonic development. Am J Clin Nutr 2000, 71:1270s.
188. Mann RK, Beachy PA Cholesterol modification of proteins. Biochim Biophys Acta 2000, 1529:188.
189. Waterham HR, Wanders RJA Biochemical and genetic aspects of 7-dehydrocholesterol reductase and Smith-Lemli-Opitz syndrome. Biochim Biophys Acta 2000, 152:340.
190. Moebius FF, et al. Genetic defects in postsqualene cholesterol biosynthesis. Trends Endocrinol Metab 2000, 11:106.
191. Wise T, et al. Relationships of light and heavy fetuses to uterine position, placental weight, gestational age, and fetal cholesterol concentrations. J Anim Sci 1997, 75:2197.
192. Schoknecht PA, et al. Dietary cholesterol supplementation improves growth and behavioral response of pigs selected for genetically high and low serum cholesterol. J Nutr 1994, 124:305.
193. Lu CD, et al. Response to dietary fat and cholesterol in young adult boars genetically selected for high or low plasma cholesterol. J Anim Sci 1995, 73:2043.
194. Cieslak DG, et al. Effect of a high fat supplement in late gestation and lactation on piglet survival and performance. J Anim Sci 1983, 57:954.
195. Schroepfer GJ Sterol biosynthesis. Annu Rev Biochem 1982, 51:555.
196. Chevallier F Transferts et synthèse du cholesterol chez le rat au cours de sa croissance. Biochim Biophys Acta 1964, 84:316.
197. Connor WE, Lin DS Placental transfer of cholesterol-4-14C into rabbit and guinea pig fetus. J Lipid Res 1967, 8:558.
198. Pitkin RM, et al. Cholesterol metabolism and placental transfer in the pregnant Rhesus monkey. J Clin Invest 1972, 51:2584.
199. Yount NY, McNamara DJ Dietary regulation of maternal and fetal cholesterol metabolism in the guinea pig. Biochim Biophys Acta 1991, 1085:82.
200. Belknap WM, Dietschy JM Sterol synthesis and low density lipoprotein clearance in vivo in the pregnant rat, placenta, and fetus. Sources for tissue cholesterol during fetal development. J Clin Invest 1988, 82:2077.
201. Woollett LA Origin of cholesterol in the fetal golden Syrian hamster: contribution of de novo sterol synthesis and maternal-derived lipoprotein cholesterol. J Lipid Res 1996, 37:1246.
202. Jurevics HA, et al. Sources of cholesterol during development of the rat fetus and fetal organs. J Lipid Res 1997, 38:723.
203. Haave NC, Innis SM Cholesterol synthesis and accretion within various tissues of the fetal and neonatal rat. Metabolism 2001, 50:12.
204. Levin MS, et al. Developmental changes in the expression of genes involved in cholesterol biosynthesis and lipid transport in human and rat fetal and neonatal livers. Biochim Biophys Acta 1989, 1003:293.
205. McNamara DJ, et al. Regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: developmental pattern. J Biol Chem 1972, 247:5805.
206. Ness GC, et al. Perinatal development of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in rat lung, liver and brain. Lipids 1979, 14:447.
207. Munilla MA, Herrera E A cholesterol-rich diet causes a greater hypercholesterolemic response in pregnant than in nonpregnant rats and does not modify fetal lipoprotein profile. J Nutr 1997, 127:2239.
208. Feingold KR, et al. De novo cholesterogenesis in pregnancy. J Lab Clin Med 1983, 101:256.
209. Haave NC, Innis SM Hepatic cholesterol and fatty acid synthesis in pregnant and fetal rats: effect of maternal dietary fat and cholestyramine. J Nutr 1991, 121:1529.
210. Gaoua W, et al. Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz syndrome animal model. J Lipid Res 2000, 41:637.
211. Barbu V, et al. Cholesterol prevents the teratogenic action of AY 9944: importance of the timing of cholesterol supplementation to rats. J Nutr 1988, 118:774.
212. McConihay JA, et al. Effect of maternal hypercholesterolemia on fetal sterol metabolism in the Golden Syrian hamster. J Lipid Res 2001, 42:1111.
213. Parker CR, et al. Analysis of the potential for transfer of lipoprotein-cholesterol across the human placenta. Early Hum Dev 1983, 8:289.
214. Ortega RM, et al. Influence of maternal serum lipids and maternal diet during the third trimester of pregnancy on umbilical cord blood lipids in two populations of Spanish newborns. Int J Vitam Nutr Res 1996, 66:250.
215. Nakai T, et al. Plasma lipids and lipoproteins of Japanese adults and umbilical cord blood. Artery 1981, 9:132.
216. Devi CS, et al. Concentration of triglyceride and cholesterol in lipoprotein fractions in maternal and cord blood samples. Clin Chim Acta 1982, 123:169.
217. Ramon y Cajal J, et al. Plasma lipids and high density lipoprotein cholesterol in maternal and umbilical vessels in twin pregnancies. Artery 1988, 15:109.
218. Neary RH, et al. Fetal and maternal lipoprotein metabolism in human pregnancy. Clin Sci (Colch) 1995, 88:311.
219. Skinner ER, et al. The composition and concentration of umbilical cord plasma lipoproteins; their relationship to the birth weight and other clinical factors of the newborn. Clin Chim Acta 1983, 135:219.
220. Diaz M, et al. Cord blood lipoprotein-cholesterol: relationship of birth weight and gestational age of newborns. Metabolism 1989, 38:435.
221. Napoli C, et al. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia: intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions. J Clin Invest 1997, 100:2680.
222. Wyne KL, Woollett LA Transport of maternal LDL and HDL to the fetal membranes and placenta of the Golden Syrian hamster is mediated by receptor-dependent and receptor-independent processes. J Lipid Res 1998, 39:518.
223. Winkel CA, et al. Uptake and degradation of lipoproteins by human trophoblastic cells in primary culture. Endocrinology 1980, 107:1892.
224. Alsat E, et al. Low-density lipoprotein binding sites in the microvillous membranes of human placenta at different stages of gestation. Mol Cell Endocrinol 1984, 38:197.
225. Winkel CA, et al. The role of receptor-mediated low-density lipoprotein uptake and degradation in the regulation of progesterone biosynthesis and cholesterol metabolism by human trophoblasts. Placenta Suppl 1981, 3:133.
226. Lasunción MA, et al. Mechanism of the HDL2 stimulation of progesterone secretion in cultured placental trophoblast. J Lipid Res 1991, 32:1073.
227. McConihay JA, et al. Maternal high density lipoproteins affect fetal mass and extra-embryonic fetal tissue sterol metabolism in the mouse. J Lipid Res 2000, 41:424.
228. Knopp RH, et al. Relationships of infant birth size to maternal lipoproteins, apoproteins, fuels, hormones, clinical chemistries, and body weight at 36 weeks gestation. Diabetes 1985, 34:271.
229. Calvo D, Vega MA Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. J Biol Chem 1993, 268:18929.
230. Hammad SM, et al. Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins. J Biol Chem 2000, 275:12003.
231. Hatzopoulos AK, et al. Temporal and spatial pattern of expression of the HDL receptor SR-BI during murine embryogenesis. J Lipid Res 1998, 39:495.
232. Seetharam B, et al. Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor. J Clin Invest 1997, 99:2317.