Optimization of the production of Momordica charantia L. Var. abbreviata Ser. protein hydrolysates with hypoglycemic effect using Alcalase

Food Chemistry

Volumn 111, Issue 2, 2008, Pages 340-344

  Yuan, Xiaoqing ^a   Gu, Xiaohong ^b   Tang, Jian ^b  

^a ZHEJIANG GONGSHANG UNIVERSITY   (China)

^b JIANGNAN UNIVERSITY   (China)

Author keywords

Alcalase 2.4L; Hypoglycemic effect; Momordica charantia L. Var. abbreviata Ser; Optimization; Protein hydrolysates

Indexed keywords

ENZYME; GLIBENCLAMIDE; MOMORDICA CHARANTIA EXTRACT; PANCREATIN; PROTEIN HYDROLYSATE; SUBTILISIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME SYNTHESIS; HYPOGLYCEMIA; MALE; MOMORDICA CHARANTIA; MOUSE; NONHUMAN; PH; PROTEIN HYDROLYSIS; RESPONSE SURFACE METHOD; TEMPERATURE MEASUREMENT;

ABBREVIATA; MOMORDICA CHARANTIA;

EID: 51749125744     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2008.03.070     Document Type: Article

References (27)

1. Adler-Nissen J. Enzymatic hydrolysis of food proteins (1986), Elsevier, New York pp. 110-131
2. Ahmed I., Lakhani M.S., Gillett M., John A., and Raza H. Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-indued rats. Diabetes Research and Clinical Practice 51 (2001) 155-161
3. Akhtar M.S., and Iqbal J. Evaluation of the hypoglycemic effect of Achyranthes aspera in normal and alloxan diabetic rabbits. Journal of Ethnopharmacology 31 (1991) 49-57
4. Baek H.H., and Cadwallader K.R. Enzymatic hydrolysis of crawfish processing by-products. Journal of Food Science 60 5 (1995) 929-935
5. Cakici I., Hurmoglu C., Tunctan B., Abacioglu N., Kanzik I., and Sener B. Hypoglycemic effect of Momordica charantia extracts in normoglycemic or cyprohepta-diene induced hyperglycaemic mice. Journal of Ethnopharmacology 44 (1994) 117-121
6. Chaturvedi P., George S., Milinganyo M., and Tripathi Y.B. Effect of Momordica charantia on lipid profile and oral glucose tolerance in diabetic rats. Phytotherapy Research 18 11 (2004) 954-956
7. Fairclough P.D., Hearty J.E., Silk D.B.A., and Clark M.L. Comparison of the absorption of two protein hydrolysates and their effect on water and electrolyte movements in the human jejunum. Gut 21 (1980) 829-834
8. Keohane P.P., Grimble G.K., Brown B., Spiller R.C., and Silk D.B.A. Influence of protein composition and hydrolysis method on intestinal absorption of protein in man. Gut 26 (1985) 907-913
9. Khanna P., Jain S.C., Panagariya A., and Dixit V.P. Hypoglycemic activity of polypeptide-P from a plant source. Journal of Natural Products 44 6 (1981) 648-655
10. Korhonen H., and Pihlanto A. Food-derived bioactive peptides - opportunities for designing future foods. Current Pharmaceutical Design 9 (2003) 1297-1308
11. Kristinsson H.G., and Rasco B.A. Biochemical and functional properties of Atlantic salmon (Salmo salar) muscle proteins hydrolyzed with various alkaline proteases. Journal of Agricultural and Food Chemistry 48 (2000) 657-666
12. Kristinsson H.G., and Rasco B.A. Kinetics of the enzymatic hydrolysis of Atlantic salmon (Salmo salar) muscle proteins by alkaline proteases and a visceral serine protease mixture. Process Biochemistry 36 (2000) 131-139
13. Mahomoodally M.F., Gurib-Fakim A., and Subratty A.H. Effect of exogenous ATP on Momordica charantia Linn. (Cucurbitaceae) induced inhibition of d-glucose, l-tyrosine and fluid transport across rat everted intestinal sacs in vitro. Journal of Ethnopharmacology 110 2 (2007) 257-263
14. Matsuda H., Li Y., Murakami T., Matsumura N., Yamahara J., and Yoshikawa M. Antidiabetic principles of natural medicines III. Structure-related inhibitory activity and action model of oleanolic acid glycosides on hypoglycemic effect. Chemical and Pharmaceutical Bulletin 46 (1998) 1399-1403
15. Mutilangi W.A.M., Panyam D., and Kilara A. Hydrolysates from proteolysis of heat-denatured whey proteins. Journal of Food Science 60 5 (1995) 1104-1109
16. Nag, B., Medicherla, S., & Sharma, S. D. (2000). Orally active fraction of Momordica charantia, active peptides thereof, and their use in the treatment of diabetes. US Patent 6127338.
17. Ng T.B., Wong C.M., Li W.W., and Yeung H.W. A steryl glycoside fractions from Momordica charantia seeds with an inhibitory action on lipid metabolism in vitro. Biochemistry and Cell Biology 64 8 (1986) 766-771
18. Rao B.K., Kesavulu M.M., and Apparao C. Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic mice. Journal of Ethnopharmacology 78 (2001) 67-71
19. Rao B.K., Kesavulu M.M., and Apparao C. Evaluation of antidiabetic effect of Momordica cymbalaria fruit in alloxan-diabetic rats. Fitoterapia 74 (2003) 7-13
20. Raza H., Ahmed I., John A., and Sharma A.K. Modulation of xenobiotic metabolism and oxidative stress in chronic streptozotocin-induced diabetic rats fed with Momordica charantia fruit extract. Journal of Biochemical and Molecular Toxicology 14 3 (2000) 131-139
21. Simpson B.K., Nayeri G., Yaylayan V., and Ashie I.N.A. Enzymatic hydrolysis of shrimp meat. Food Chemistry 61 (1998) 131-138
22. Tolman K.G., and Chandramouli J. Hepatotoxicity of the thiazolidinediones. Clinics in Liver Disease 7 (2003) 369-370
23. Xia S.H., Wang Z., and Xu S.Y. Characteristics of Bellamya purificata snail foot protein and enzymatic hydrolysates. Food Chemistry 101 (2007) 1188-1196
24. Yamamoto Y., Nakajima M., Yamazaki H., and Yokoi T. Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells. Life Science 70 (2001) 471-482
25. Yuan X.Q., Gu X.H., Tang J., and Wasswa J. Hypoglycemic effect of semi-purified peptides from Momordica charantia L. Var. abbreviata Ser. in alloxan-induced diabetic mice. Journal of Food Biochemistry 32 (2008) 107-121
26. Zhao, H.W. (2005). Studies on extraction and hypoglycemic effect of saponins of Momordica charantia L. Var. Abbreviata Ser. Master dissertation. Wuxi: Jiangnan University.
27. Zheng J. Functional food (1999), China Light Industry Press, Beijing