Anti-IL-6 receptor antibody increases blood IL-6 level via the blockade of IL-6 clearance, but not via the induction of IL-6 production

International Immunopharmacology

Volumn 8, Issue 11, 2008, Pages 1595-1601

  Uchiyama, Yasushi ^a   Yoshida, Hiroto ^a   Koike, Nobuo ^a   Hayakawa, Naohiko ^a   Sugita, Atsuko ^a   Nishimura, Takashi ^b   Mihara, Masahiko ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b Institute for Genetic Medicine   (Japan)

Author keywords

Anti IL 6R antibody; Clearance; IL 6; Protein synthesis; Soluble IL 6R

Indexed keywords

ATLIZUMAB; COLLAGEN TYPE 2; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MR16 1; RECOMBINANT INTERLEUKIN 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNOMODULATION; IMMUNOTHERAPY; LIVER; LYMPH NODE; MACACA; MALE; MOUSE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; SPLEEN; SYNOVIUM;

ANIMALS; ANTIBODIES, MONOCLONAL; ARTHRITIS, EXPERIMENTAL; C-REACTIVE PROTEIN; FEMALE; HUMANS; INTERLEUKIN-6; MACACA FASCICULARIS; MALE; MICE; MICE, MUTANT STRAINS; RECEPTORS, INTERLEUKIN-6; RNA, MESSENGER;

EID: 51749087872     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2008.07.002     Document Type: Article

References (18)

1. Akira S., Taga T., and Kishimoto T. Interleukin-6 in biology and medicine. Adv Immunol 54 (1993) 1-78
2. Kishimoto T., Akira S., Narazaki M., and Taga T. Interleukin-6 family of cytokines and gp130. Blood 86 (1995) 1243-1254
3. Mihara M., Kasutani K., Okazaki M., Nakamura A., Kawai S., Sugimoto M., et al. Tocilizumab inhibits signal transduction mediated by both mIL-6R and sIL-6R, but not by the receptors of other members of IL-6 cytokine family. Int Immunopharmacol 5 (2005) 1731-1740
4. Nishimoto N., Kanakura Y., Aozasa K., Johkoh T., Nakamura M., Nakano S., et al. Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood 106 (2005) 2627-2632
5. Nishimoto N., Yoshizaki K., Miyasaka N., Yamamoto K., Kawai S., Takeuchi T., et al. Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum 50 (2004) 1761-1769
6. Ito H., Takazoe M., Fukuda Y., Hibi T., Kusugami K., Andoh A., et al. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 126 (2004) 989-996
7. Yokota S., Miyamae T., Imagawa T., Iwata N., Katakura S., Mori M., et al. Therapeutic efficacy of humanized recombinant anti-interleukin-6 receptor antibody in children with systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 52 (2005) 818-825
8. Nishimoto N., Terao K., Kakehi T., and Kishimoto T. Increase in serum IL-6 and soluble IL-6 receptor after anti-IL-6 receptor antibody therapy in patients with rheumatoid arthritis. Arthritis Rheum 50 (2004) S109 (Suppl)
9. Wendling D., Racadot E., and Wijdenes J. Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody. J Rheumatol 20 (1993) 259-262
10. Hirano T., Matsuda T., Turner M., Miyasaka N., Buchan G., Tang B., et al. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol 18 (1988) 1797-1801
11. Mahida Y.R., Kurlac L., Gallagher A., and Hawkey C.J. High circulating concentrations of interleukin-6 in active Crohn's disease but not ulcerative colitis. Gut 32 (1991) 1531-1534
12. Gaillard J.P., Bataille R., Brailly H., Zuber C., Yasukawa K., Attal M., et al. Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy. Eur J Immunol 23 (1993) 820-824
13. Narazaki M., Yasukawa K., Saito T., Ohsugi Y., Fukui H., Koishihara Y., et al. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood 82 (1993) 1120-1126
14. Mihara M., Kotoh M., Nishimoto N., Oda Y., Kumagai E., Takagi N., et al. Humanized antibody to human interleukin-6 receptor inhibits the development of collagen arthritis in cynomolgus monkeys. Clin Immunol 98 (2001) 319-326
15. Uchiyama Y., Yorozu K., Hashizume M., Moriya Y., and Mihara M. Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis. Biol Pharm Bull 31 (2008) 1159-1163
16. Sato K., Tsuchiya M., Saldanha J., Koishihara Y., Ohsugi Y., Kishimoto T., et al. Humanization of a mouse anti-human interleukin-6 receptor antibody comparing two methods for selecting human framework regions. Mol Immunol 31 (1994) 371-381
17. Okazaki M., Yamada Y., Nishimoto N., Yoshizaki K., and Mihara M. Characterization of anti-mouse interleukin-6 receptor antibody. Immunol Lett 84 (2002) 231-240
18. Imazeki I., Saito H., Hasegawa M., Shinkura H., Kishimoto T., and Ohsugi Y. IL-6 functions in cynomolgus monkeys blocked by a humanized antibody to human IL-6 receptor. Int J Immunopharmacol 20 (1998) 345-357