Influence of genotyping error in linkage mapping for complex traits - An analytic study

BMC Genetics

Volumn 9, Issue , 2008, Pages

  Lebrec, Jérémie J P ^a   Putter, Hein ^a   Houwing Duistermaat, Jeanine J ^a   Van Houwelingen, Hans C ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL ERROR; ARTICLE; EPIDEMIOLOGICAL DATA; FAMILY STUDY; GENE CONTROL; GENE MAPPING; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC TRAIT; GENOTYPE; HOMOZYGOSITY; HUMAN; LINKAGE ANALYSIS; MATHEMATICAL ANALYSIS; METHODOLOGY; MICROARRAY ANALYSIS; POPULATION GENETICS; QUANTITATIVE ANALYSIS; QUANTITATIVE TRAIT LOCUS; REGRESSION ANALYSIS; SIBLING; SINGLE NUCLEOTIDE POLYMORPHISM; BIOLOGICAL MODEL; CHROMOSOME MAP; QUANTITATIVE TRAIT; STATISTICAL ANALYSIS;

CHROMOSOME MAPPING; GENOTYPE; HUMANS; LINKAGE (GENETICS); MATCHED-PAIR ANALYSIS; MODELS, GENETIC; QUANTITATIVE TRAIT, HERITABLE; REGRESSION ANALYSIS;

EID: 51649125709     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/1471-2156-9-57     Document Type: Article

References (18)

1. Amos CI Chen WV Lee A Li W Kern M Lundsten R Batliwalla F Wener M Remmers E Kastner DA Criswell LA Seldin MF Gregersen PK High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33 Genes Immun 2006, 7:277-286 10.1038/sj.gene.6364295 16691188
2. Evans DM Cardon LR Guidelines for genotyping in genomewide linkage studies: Single-nucleotide-polymorphism maps versus microsatellite maps Am J Hum Genet 2004, 75:687-692 1182056 15311375 10.1086/424696
3. Schaid DJ Guenther J Christensen G Hebbring S Rosenow C Hilker C McDonnell S Cunningham J Slager S Blute M Thibodeau SN Comparison of microsatellites versus single-nucleotide polymorphisms in a genome linkage screen for prostate cancer-susceptibility loci Am J Hum Genet 2004, 75:948-965 1182157 15514889 10.1086/425870
4. Douglas JA Boehnke M Lange K A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data Am J Hum Genet 2000, 66:1287-1297 1288195 10739757 10.1086/302861
5. Abecasis GR Cherny SS Cardon LR The impact of genotyping error on family-based analysis of quantitative traits Eur J Hum Genet 2001, 9:130-134 10.1038/sj.ejhg.5200594 11313746
6. Walters K The effect of genotyping error in sib-pair genomewide linkage scans depends crucially upon the method of analysis J Hum Genet 2005, 50:329-337 10.1007/s10038-005-0269-1 16059746
7. Sham PC Purcell S Equivalence between Haseman-Elston and Variance-Components linkage analyses for sib-pairs Am J Hum Genet 2001, 68:1527-1532 1226141 11353401 10.1086/320593
8. Tang HK Siegmund D Mapping quantitative trai loci in oligogenic models Biostatistics 2001, 2:147-162 10.1093/biostatistics/2.2.147 12933546
9. Skatkiewicz JP Cuenco KT Feingold E Recent advances in human Quantitative-Trait-Locus mapping: Comparison of methods for discordant sibling pairs Am J Hum Genet 2003, 73:874-885 1180609 12970846 10.1086/ 378590
10. Cuenco KT Skatkiewicz JP Feingold E Recent advances in human Quantitative-Trait-Locus mapping: Comparison of methods for selected sibling pairs Am J Hum Genet 2003, 73:863-873 1180608 12970847 10.1086/ 378589
11. Sobel E Papp J Lange K Detection and integration of genotyping errors in statistical genetics Am J Hum Genet 2002, 70:496-508 384922 11791215 10.1086/338920
12. Putter H Lebrec J van Houwelingen JC Selection Strategies for Linkage Studies Using Twins Twin Res 2003, 6:377-382 10.1375/136905203770326376 14624721
13. Lebrec J Putter H van Houwelingen JC Score test for detecting linkage to complex traits in selected samples Genet Epidemiol 2004, 27:97-108 10.1002/gepi.20012 15305326
14. Ewen K Bahlo M Treloar S Levinson D Mowry B Barlow J Foote S Identification and analysis of error types in high-throughput genotyping Am J Hum Genet 2000, 67:727-736 1287531 10924406 10.1086/303048
15. Devlin B Roeder K Genomic control for association studies Biometrics 1999, 55:997-1004 10.1111/j.0006-341X.1999.00997.x 11315092
16. Kruglyak L Daly MJ Reeve-Daly MP Lander ES Parametric and nonparametric linkage analysis: A unified multipoint approach Am J Hum Genet 1996, 58:1347-1363 1915045 8651312
17. Abecasis GR Cherny SS Cookson WO Cardon LR Merlin - rapid analysis of dense genetic maps using sparse gene flow trees Nat Genet 2002, 30:97-101 10.1038/ng786 11731797
18. Elston RC Song D Iyengar SK Mathematical Assumptions versus Biological Reality: Myths in Affected Sib Pair Linkage Analysis Am J Hum Genet 2005 76 152 156 1196418 15540158 10.1086/426872