Selection Strategies for Linkage Studies Using Twins

Twin Research

Volumn 6, Issue 5, 2003, Pages 377-382

  Putter, Hein ^a   Lebrec, Jeremie ^a   Van Houwelingen, Hans C ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BODY HEIGHT; CALCULATION; GENE IDENTIFICATION; GENE LOCATION; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC DISORDER; GENETIC LINKAGE; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; HERITABILITY; HUMAN; INSULIN BLOOD LEVEL; LINKAGE ANALYSIS; MEDICAL RESEARCH; MIGRAINE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REGISTER; REVIEW; SAMPLE SIZE; SIBLING; STATISTICAL MODEL; TECHNIQUE; TWINS;

HUMANS; LINKAGE (GENETICS); MATHEMATICS; MODELS, THEORETICAL; RANDOM ALLOCATION; TWIN STUDIES;

EID: 0347364732     PISSN: 13690523     EISSN: None     Source Type: Journal    
DOI: 10.1375/136905203770326376     Document Type: Review

References (19)

1. Abecasis, G. R., Cherny, S. S., Cookson, W. O., & Cardon, L. R. (2002). Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nature Genetics, 30, 97-101.
2. Amos, C. I. (1994). Robust variance-components approach for assessing genetic linkage in pedigrees. American Journal of Human Genetics, 54, 535-543.
3. Boomsma, D., Busjahn, A., & Peltonen, L. (2002). Classical twin studies and beyond. Nature Review Genetics, 3, 872-882.
4. Cherny, S. S., Purcell, S., Rijsdijk, F., Hewitt, J. K., & Sham, P. C. (1999). Selecting maximally informative sibships for QTL linkage analysis. Behavior Genetics, 29, 352-352.
5. Dolan, C. V., & Boomsma, D. I. (1998). Optimal selection of sib pairs from random samples for linkage analysis of a QTL using the EDAC test. Behavior Genetics, 28, 197-206.
6. Dolan, C. V., Boomsma, D. I., & Neale, M. C. (1999). A note of the power provided by sibships of sizes 2, 3 and 4 in genetic covariance modeling of co-dominant QTL. Behavior Genetics, 29, 163-170.
7. Eaves, L., & Meyer, J. (1994). Locating human quantitative trait loci - guidelines for the selection of sibling pairs for genotyping. Behavior Genetics, 24, 443-455.
8. Lebrec, J., Putter, H., & van Houwelingen, J. C. (2003). Score test for linkage analysis of complex traits using selected samples. Unpublished manuscript.
9. Purcell, S., Cherny, S. S., Hewitt, J. K., & Sham, P. C. (2001). Optimal sibship selection for genotyping in quantitative trait locus linkage analysis. Human Heredity, 52, 1-13.
10. Putter, H., Sandkuijl, L. A., & van Houwelingen, J. C. (2002). Score test for detecting linkage to quantitative traits. Genetic Epidemiology 22, 345-355.
11. Rijsdijk, F. V., & Sham, P. C. (2000). Effects of pedigree structure and genetic model on the power of QTL linkage analysis. Behavior Genetics, 30, 417.
12. Rijsdijk, F. V., Hewitt, J. K., & Sham, P. C. (2001). Analytic power calculation for QTL linkage analysis of small pedigrees. European Journal of Human Genetics, 9, 335-340.
13. Risch, N., & Zhang, H. (1995). Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science, 268, 1584-1589.
14. Risch, N. J. (2000). Searching for genetic determinants in the new millennium. Nature, 405, 847-856.
15. Schork, N. J. (1993). Extended multipoint identify-by-descent analysis of human quantitative traits - efficiency, power and modeling considerations. American Journal of Human Genetics, 53, 1306-1319.
16. Sham, P. C., & Purcell, S. (2001). Equivalence between Haseman-Elston and variance-components linkage analyses for sib-pairs. American Journal of Human Genetics, 68, 1527-1532.
17. Sham, P. C., Purcell, S., Cherny, S. S., & Abecasis, G. R. (2002). Powerful regression-based quantitative-trait linkage analysis of general pedigrees. American Journal of Human Genetics, 71, 238-253.
18. Sham, P. C., Zhao, J. H., Cherny, S. S., & Hewitt, J. K. (2000). Variance-components QTL linkage analysis of selected and nonnormal samples: Conditioning on trait values. Genetic Epidemiology, 19, S22-S28.
19. Williams, J. T., & Blangero, J. (1999). Power of variance component linkage analysis to detect quantitative trait loci. Annals of Human Genetics, 63, 545-563.