Recent Advances in Human Quantitative-Trait-Locus Mapping: Comparison of Methods for Selected Sibling Pairs

American Journal of Human Genetics

Volumn 73, Issue 4, 2003, Pages 863-873

  T Cuenco, Karen ^a   Szatkiewicz, Jin P ^b   Feingold, Eleanor ^a,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL ERROR; ARTICLE; DATA ANALYSIS; INTERMETHOD COMPARISON; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS MAPPING; REGRESSION ANALYSIS; SIBLING; SIMULATION; STATISTICAL ANALYSIS;

EID: 0142091192     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/378589     Document Type: Article

References (26)

1. Allison DB, Fernández JR, Heo M, Beasley TM (2000) Testing the robustness of the new Haseman-Elston quantitative-trait loci-mapping procedure. Am J Hum Genet 67:249-252
2. Allison DB, Neale MC, Zannolli R, Schork NJ, Amos CI, Blangero J (1999) Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure. Am J Hum Genet 65:531-544
3. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211
4. Amos CI (1994) Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet 54: 535-543
5. Drigalenko E (1998) How sib pairs reveal linkage. Am J Hum Genet 63:1242-1245
6. Elston RC, Buxbaum S, Jacobs KB, Olson JM (2000) Haseman and Elston revisited. Genet Epidemiol 19:1-17
7. Feingold E (2001) Methods for linkage analysis of quantitative trait loci in humans. Theor Popul Biol 60:167-180
8. _ (2002) Regression-based quantitative-trait-locus mapping in the 21st century. Am J Hum Genet 71:217-222
9. Forrest W (2001) Weighting improves the "new Haseman-Elston" method. Hum Hered 52:47-54
10. Ghosh S, Reich T (2002) Integrating sibship data for mapping quantitative trait loci. Ann Hum Genet 66:169-182
11. Goldstein DR, Dudoit S, Speed TP (2001) Power and robustness of a score test for linkage analysis of quantitative traits using identity by descent data on sib pairs. Genet Epidemiol 20:415-431
12. Haseman JK, Elston RC (1972) The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3-19
13. Palmer LJ, Jacobs KB, Elston RC (2000) Haseman and Elston revisited: the effects of ascertainment and residual familial correlations on the power to detect linkage. Genet Epidemiol 19:456-460
14. Putter H, Sandkuijl LA, van Houwelingen JC (2002) Score test for detecting linkage to quantitative traits. Genet Epidemiol 22:345-335
15. Sham PC, Purcell S (2001) Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs. Am J Hum Genet 68:1527-1532
16. Sham PC, Purcell S, Cherny SS, Abecasis GR (2002) Powerful regression-based quantitative-trait linkage analysis of general pedigrees. Am J Hum Genet 71:238-253
17. Szatkiewicz JP, T.Cuenco K, Feingold E (2003) Recent advances in human quantitative-trait-locus mapping - comparison of methods for discordant sibling pairs. 73:874-885 (in this issue)
18. Tang H-K, Siegmund D (2001) Mapping quantitative trait loci in oligogenic models. Biostatistics 2:147-162
19. _ (2002) Mapping multiple genes for quantitative or complex traits. Genet Epidemiol 22:313-327
20. Visscher PM, Hopper JL (2001) Power of regression and maximum likelihood methods to map QTL from sib-pair and DZ twin data. Ann Hum Genet 65:583-601
21. Wang K (2002) Efficient score statistics for mapping quantitative trait loci with extended pedigrees. Hum Hered 54: 57-68
22. Wang K, Huang J (2002a) A score-statistic approach for the mapping of quantitative-trait loci with sibships of arbitrary size. Am J Hum Genet 70:412-424
23. _ (2002b) Score test for mapping quantitative-trait loci with sibships of arbitrary size when the dominance effect is not negligible. Genet Epidemiol 23:398-412
24. Xu X, Weiss S, Xu X, Wei LJ (2000) A unified Haseman-Elston method for testing linkage with quantitative traits. Am J Hum Genet 67:1025-1028
25. Zhang W, Collins A, Lonjou C, Morton NE (2002) A linkage tournament: affection status, parametric analysis, multivariate traits, and enhancements to variance components and relative pairs. Ann Hum Genet 66:87-98
26. Zhang W, Tapper W, Collins A, Jacobs KB, Elston RC (2001) A tournament of linkage tests in complex inheritance. Hum Hered 52:140-148