Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm

Blood

Volumn 112, Issue 4, 2008, Pages 1154-1157

  Mitola, Stefania ^a   Moroni, Emanuela ^a   Ravelli, Cosetta ^a   Andres, German ^a   Belleri, Mirella ^a   Presta, Marco ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; ANGIOPOIETIN RECEPTOR; BONE MORPHOGENETIC PROTEIN; CELL RECEPTOR; COLLAGEN TYPE 1; FIBRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN DRM; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ANGIOGENIC PROTEIN; CKTSF1B1 PROTEIN, MOUSE; GREM1 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; AUTOCRINE EFFECT; CHICK EMBRYO; DRUG ANTAGONISM; GENETICS; METABOLISM; PHYSIOLOGY; UPREGULATION;

ANGIOGENIC PROTEINS; ANGIOPOIETIN-1; ANIMALS; AUTOCRINE COMMUNICATION; BONE MORPHOGENETIC PROTEINS; CHICK EMBRYO; ENDOTHELIAL CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; NF-KAPPA B; RECEPTOR, TIE-2; UP-REGULATION;

EID: 51649116092     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-09-111450     Document Type: Article

References (20)

1. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000;407:249-257.
2. Fiedler U, Augustin HG. Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol. 2006;27:552-558.
3. Cascone I, Audero E. Giraudo E, et al. Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1. Blood. 2003;102:2482-2490.
4. Cho CH, Sung HK, Kim KT. et al. COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model. Proc Natl Acad Sci U S A. 2006;103:4946-4951.
5. Suri C, McClain J, Thurston G, et al. Increased vascularization in mice overexpressing angiopoietin-1. Science. 1998:282:468-471.
6. Pearce JJ, Penny G, Rossant J. A mouse cerbe-rus/Dan-related gene family. Dev Biol. 1999;209: 98-110.
7. Balemans W, Van Hul W. Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators. Dev Biol. 2002;250:231-250.
8. Stabile H, Mitola S, Moroni E, et al. Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. Blood. 2007;109:1834-1840.
9. Namkoong H, Shin SM, Kim HK, et al.The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein. BMC Cancer. 2006;6:74-87.
10. Sneddon JB, Zhen HH, Montgomery K, et al. Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proc Natl Acad Sci U S A. 2006;103:14842-14847.
11. Poliani PL, Mitola S, Ravanini M, et al. CEACAM1/VEGF cross-talk during neuroblastic tumour differentiation. J Pathol. 2007;211:541-549.
12. Belleri M. Ribatti D, Nicoli S, et al. Antiangiogenic and vascular targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4'-trimethoxystilbene. Mol Pharmacol. 2005;67: 1451-1459.
13. Audero E, Cascone I, Maniero F, et al. Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells. J Biol Chem. 2004:279:13224-13233.
14. Belleri M, Ribatti D, Nicoli S, et al. Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4'-trimethoxystilbene. Mol Pharmacol. 2005;67:1451-1459.
15. Knoll A, Schmidt S, Chapman M, et al. A comparison of two controlled-release delivery systems for the delivery of amiloride to control angiogenesis. Microvasc Res. 1999;58:1-9.
16. Ribatti D, Nico B, Vacca A, Presta M. The gelatin sponge-chorioallantoic membrane assay. Nat Protoc. 2006;1:85-91.
17. De Martin R, Hoeth M, Hofer-Warbinek R, Schmid JA. The transcription factor NF-kappa B and the regulation of vascular cell function. Arte-rioscler Thromb Vase Biol. 2000;20:E83-E88.
18. Scott BB, Zaratin PF Gilmartin AG, et al. TNF-alpha modulates angiopoietin-1 expression in rheumatoid synovial fibroblasts via the NF-kappa B signalling pathway. Biochem Biophys Res Commun. 2005;328:409-414.
19. Park YS, Kim NH, Jo I. Hypoxia and vascular endothelial growth factor acutely up-regulate angiopoietin-1 and Tie2 mRNA in bovine retinal pericytes. Microvasc Res. 2003;65:125-131.
20. Zacharek A, Chen J, Zhang C, et al. Nitric oxide regulates Angiopoietin1/Tie2 expression after stroke. Neurosci Lett. 2006;404:28-32.