Characterization of umami receptor and coupling G protein in mouse taste cells

NeuroReport

Volumn 19, Issue 12, 2008, Pages 1169-1173

  Narukawa, Masataka ^a   Kitagawa Iseki, Keiko ^a   Oike, Hideaki ^b,c   Abe, Keiko ^b   Mori, Tomohiko ^a   Hayashi, Yukako ^a  

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

Author keywords

gustducin; Inhibitory G protein subunit; Signal transduction; Taste; Umami

Indexed keywords

CALCIUM; G PROTEIN COUPLED RECEPTOR; GDP BETA S; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT GUSTDUCIN; PERTUSSIS TOXIN; PROTEIN INHIBITOR; RECEPTOR; UMAMI RECEPTOR; UNCLASSIFIED DRUG; ALPHA GUSTDUCIN, MOUSE; ALPHA-GUSTDUCIN, MOUSE; DRUG DERIVATIVE; GUANOSINE 5' O (2 THIODIPHOSPHATE); GUANOSINE 5'-O-(2-THIODIPHOSPHATE); GUANOSINE DIPHOSPHATE; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; NUCLEOTIDE; TASTE RECEPTORS, TYPE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL ACTIVATION; CELL TYPE; ELECTROPHYSIOLOGY; FEMALE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STIMULUS; TASTE BUD; TASTE RECEPTOR CELL; UMAMI STIMULUS; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOCHEMISTRY; METABOLISM; PATCH CLAMP; PHYSIOLOGY; TASTE;

ANIMALS; CALCIUM; ELECTROPHYSIOLOGY; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEINS; GUANOSINE DIPHOSPHATE; HETEROTRIMERIC GTP-BINDING PROTEINS; IMMUNOCHEMISTRY; MICE; MICE, INBRED C57BL; PATCH-CLAMP TECHNIQUES; PERTUSSIS TOXIN; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; TASTE; TASTE BUDS; THIONUCLEOTIDES;

EID: 51649112997     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e328308b36c     Document Type: Article

References (22)

1. Kuninaka A, Kibi M, Sakaguchi K. History and development of flavor nucleotides. Food Technol 1964; 18:287-293.
2. Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS. The receptors and cells for mammalian taste. Nature 2006; 444:288-294.
3. Kitagawa M, Kusakabe Y, Miura H, Ninomiya Y, Hino A. Molecular genetic identification of a candidate receptor gene for sweet taste. Biochem Biophys Res Commun 2001; 283:236-242.
4. Sainz E, Korley JN, Battey JF, Sulliva SL. Identification of a novel member of the T1R family of putative taste receptors. J Neurochem 2001; 77:896-903.
5. Matunami H, Montmayeur JP, Buck LB. A family of candidate taste receptors in human and mouse. Nature 2000; 404:601-604.
6. Toyono T, Seta Y, Kataoka S, Kawano S, Shigemoto R, Toyoshima K. Expression of metabotropic glutamate receptor group I in rat gustatory papillae. Cell Tissue Res 2003; 313:29-35.
7. Chaudhari N, Yang H, Lamp C, Delay E, Cartford C, Than T, et al. The taste of monosodium glutamate: membrane receptors in taste buds. J Neurosci 1996; 16:3817-3826.
8. Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E. Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A 2002; 99:4692-4696.
9. McLaughlin SK, McKinnon PJ, Margolskee RF. Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 1992; 357:563-569.
10. Rossler P, Kroner C, Freitag J, Noe J, Breer H. Identification of a phospholipase C beta subtype in rat taste cells. Eur J Cell Biol 1998; 77:253-261.
11. Perez CA, Huang L, Rong M, Kozak JA, Preuss AK, Zhang H, et al. A transient receptor potential channel expressed in taste receptor cells. Nat Neurosci 2002; 5:1169-1176.
12. Lindemann B. Receptors and transduction in taste. Nature 2001; 413:219-225.
13. Kusakabe Y, Yasuoka A, Asano-Miyoshi M, Iwabuchi K, Matumoto I, Arai S, et al. Comprehensive study on G protein α-subunits in taste bud cells, with special reference to the occurrence of Gαi2 as a major Gα species. Chem Senses 2000; 25:525-531.
14. Abaffy T, Trubey KR, Chaudhari N. Adenylyl cyclase expression and modulation of cAMP in rat taste cells. Am J Physiol Cell Physiol 2003; 284:C1420-C1428.
15. Lin W, Ogura T, Kinnamon SC. Responses to di-sodium guanosine 5′-monophosphate and monosodium -glutamate in taste receptor cells of rat fungiform papillae. J Neurophysiol 2003; 89:1434-1439.
16. Birnbaumer L, Brown AM. G proteins and the mechanism of action of hormones, neurotransmitters, and autocrine and paracrine regulatory factors. Am Rev Respir Dis 1990; 141 (3 Pt 2):S106-S114.
17. Wong GT, Gannon KS, Margolskee RF. Transduction of bitter and sweet taste by gustducin. Nature 1996; 381:796-800.
18. He W, Yasumatsu K, Varadarajan V, Yamada A, Lem J, Ninomiya Y, et al. Umami taste responses are mediated by α-transducin and α-gustducin. J Neurosci 2004; 24:7674-7680.
19. Bigiani A, Cristiani R, Fieni F, Ghiaroni V, Bagnoli P, Pietra P. Postnatal development of membrane excitability in taste cells of the mouse vallate papilla. J Neurosci 2002; 22:493-504.
20. Iseki K, Hayashi Y, Oh SH, Teeter J, Restrepo D, Mori T. Umami taste: electrophysiological recordings of synergism in mouse taste cells. Sensory Neuron 2001; 3:155-167.
21. Hermans E, Challiss RA. Structural, signaling and regulatory properties of group I metabotropic glutamate receptors: prototype family C G-protein-coupled receptors. Biochem J 2001; 359:465-484.
22. Kim MR, Kusakabe Y, Miura H, Shindo Y, Ninomiya Y, Hino A. Regional expression patterns of T1R family in the mouse tongue. Biochem Biophys Res Commun 2003; 312:500-506.