Immunostimulatory lipid implants containing Quil-A and DC-cholesterol

International Journal of Pharmaceutics

Volumn 363, Issue 1-2, 2008, Pages 91-98

  Myschik, Julia ^a   McBurney, Warren T ^a   Rades, Thomas ^a   Hook, Sarah ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

CD8+ T cell; DC cholesterol; Immune response; Lipid implant; Quil A; Sustained release; Vaccine

Indexed keywords

ADJUVANT; ALUMINUM POTASSIUM SULFATE; ANTIGEN; CATION; CD4 ANTIGEN; CHOLESTEROL DERIVATIVE; LIPID; OVALBUMIN; PHOSPHATIDYLCHOLINE; QUIL A; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; BIOCOMPATIBILITY; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOSTIMULATION; IMPLANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE;

ADJUVANTS, IMMUNOLOGIC; ALUM COMPOUNDS; ANIMALS; ANTIBODIES; ANTIBODY FORMATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHOLESTEROL; DRUG COMPOUNDING; DRUG IMPLANTS; IMMUNITY, CELLULAR; INJECTIONS; KINETICS; LIPOSOMES; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; OVALBUMIN; PHOSPHATIDYLCHOLINES; SAPONINS; SOLUBILITY; VACCINES;

EID: 51649091575     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.07.014     Document Type: Article

References (28)

1. Allison A.C., and Gregoriadis G. Liposomes as immunological adjuvants. Nature 252 (1974) 252
2. Bangham A.D., Horne R.W., Glauert A.M., Dingle J.T., and Lucy J.A. Action of saponin on biological cell membranes. Nature 196 (1962) 952-955
3. Bramwell V.W., and Perrie Y. Particulate delivery systems for vaccines. Crit. Rev. Ther. Drug Carrier Syst. 22 (2005) 151-214
4. Bramwell V.W., and Perrie Y. The rational design of vaccines. Drug Discov. Today 10 (2005) 1527-1534
5. Bramwell V.W., and Perrie Y. Particulate delivery systems for vaccines: what can we expect?. J. Pharm. Pharmacol. 58 (2006) 717-728
6. Brunel F., Darbouret A., and Ronco J. Cationic lipid DC-Chol induces an improved and balanced immunity able to overcome the unresponsiveness to the hepatitis B vaccine. Vaccine 17 (1999) 2192-2203
7. Copland M.J., Rades T., and Davies N.M. Hydration of lipid films with an aqueous solution of Quil A: a simple method for the preparation of immune-stimulating complexes. Int. J. Pharm. 196 (2000) 135-139
8. Copland M.J., Rades T., Davies N.M., and Baird M.A. Lipid based particulate formulations for the delivery of antigen. Immunol. Cell. Biol. 83 (2005) 97-105
9. Demana P.H., Davies N.M., Hook S., and Rades T. Quil A-lipid powder formulations releasing ISCOMs and related colloidal structures upon hydration. J. Control. Release 103 (2005) 45-59
10. Farhood H., Bottega R., Epand R.M., and Huang L. Effect of cationic cholesterol derivatives on gene transfer and protein kinase C activity. Biochim. Biophys. Acta-Biomembr. 1111 (1992) 239-246
11. Friede M., and Aguado M.T. Need for new vaccine formulations and potential of particulate antigen and DNA delivery systems. Adv. Drug Deliv. Rev. 57 (2005) 325-331
12. Gao X., and Huang L. A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem. Biophys. Res. Commun. 179 (1991) 280-285
13. Goyal K., and Huang L. Gene therapy using Dc-Chol liposomes. J. Liposome Res. 5 (1995) 49-60
14. Gregoriadis G. Immunological adjuvants: a role for liposomes. Immunol. Today 11 (1990) 89-97
15. Gupta R.K. Aluminium compounds as vaccine adjuvants. Adv. Drug Deliv. Rev. 32 (1998) 155-172
16. Guy B., Pascal N., Francon A., Bonnin A., Gimenez S., Lafay-Vialon E., Trannoy E., and Haensler J. Design, characterization and preclinical efficacy of a cationic lipid adjuvant for influenza split vaccine. Vaccine 19 (2001) 1794-1805
17. Hauser H. Some aspects of the phase behaviour of charged lipids. Biochim. Biophys. Acta-Biomembr. 772 (1984) 37-50
18. Hui K.M., Sabapathy T.K., Oei A.A., Singhal A., and Huang L. Induction of alloreactive cytotoxic T lymphocytes by intra-splenic immunization with allogeneic class I Major Histocompatibility Complex DNA and DC-chol cationic liposomes. J. Liposome Res. 4 (1994) 1075-1090
19. McBurney W.T., Lendemans D.G., Myschik J., Hennessy T., Rades T., and Hook S. In vivo activity of cationic immune stimulating complexes (PLUSCOMs). Vaccine 26 (2008) 4549-4556
20. Myschik J., Eberhardt F., Rades T., and Hook S. Immunostimulatory biodegradable implants containing the adjuvant Quil-A-Part I: Physicochemical characterisation. J. Drug Target 16 (2008) 213-223
21. Myschik J., McBurney W.T., Hennessy T., Phipps-Green A., Rades T., and Hook S. Immunostimulatory biodegradable implants containing the adjuvant Quil-A-Part II: In vivo evaluation. J. Drug Target 16 (2008) 224-232
22. Myschik, J., McBurney, W.T., Hennessy, T., Rades, T., Hook, S. 2008. Immunogenicity of lipid sustained release implants containing imiquimod, α-galactosylceramide, or Quil-A. Die Pharmazie, in press, doi:10.1691/ph.2008.8072.
23. Nakanishi T., Kunisawa J., Hayashi A., Tsutsumi Y., Kubo K., Nakagawa S., Fujiwara H., Hamaoka T., and Mayumi T. Positively charged liposome functions as an efficient immunoadjuvant in inducing immune responses to soluble proteins. Biochem. Biophys. Res. Commun. 240 (1997) 793-797
24. Nakanishi T., Kunisawa J., Hayashi A., Tsutsumi Y., Kubo K., Nakagawa S., Nakanishi M., Tanaka K., and Mayumi T. Positively charged liposome functions as an efficient immunoadjuvant in inducing cell-mediated immune response to soluble proteins. J. Control. Release 61 (1999) 233-240
25. Perrie Y., McNeil S., and Vangala A. Liposome-mediated DNA immunisation via the subcutaneous route. J. Drug Target 11 (2003) 555-563
26. Sternberg B., Sorgi F.L., and Huang L. New structures in complex formation between DNA and cationic liposomes visualized by freeze-fracture electron microscopy. FEBS Lett. 356 (1994) 361
27. Storni T., Kuendig T.M., Senti G., and Johansen P. Immunity in response to particulate antigen-delivery systems. Adv. Drug Deliv. Rev. 57 (2005) 333-355
28. Wu C.M., Liou W., Chen H.L., Lin T.L., and Jeng U.S. Self-assembled structure of the binary complex of DNA with cationic lipid. Macromolecules 37 (2004) 4974-4980