Proof of hazard and proof of safety in toxicological studies using simultaneous confidence intervals for differences and ratios to control

Journal of Biopharmaceutical Statistics

Volumn 18, Issue 5, 2008, Pages 915-933

  Hothorn, Ludwig A ^a   Hasler, Mario ^a  

^a LEIBNIZ UNIVERSITY HANNOVER   (Germany)

Author keywords

Proof of hazard; Proof of safety; Regulatory toxicology; Simultaneous confidence intervals

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CARCINOGENICITY; CHRONIC TOXICITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG SAFETY; ERYTHROCYTE; HEALTH HAZARD; MOUSE; NONHUMAN; PRIORITY JOURNAL; SAMPLE SIZE; STATISTICAL ANALYSIS; TOXICITY TESTING;

ANIMALS; CONFIDENCE INTERVALS; DATA INTERPRETATION, STATISTICAL; MICE; RATS; RESEARCH DESIGN; TOXICOLOGY;

EID: 51649090660     PISSN: 10543406     EISSN: 15205711     Source Type: Journal    
DOI: 10.1080/10543400802287511     Document Type: Article

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