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Activation of the ethylene gas response pathway in Arabidopsis by nuclear protein ETHYLENE-INSENSITIVE3 and related proteins
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Chao Q., Rothenberg M., Solano R., Roman G., Terzaghi W., and Ecker J.R. Activation of the ethylene gas response pathway in Arabidopsis by nuclear protein ETHYLENE-INSENSITIVE3 and related proteins. Cell 89 (1997) 1133-1144
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Cell
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Chao, Q.1
Rothenberg, M.2
Solano, R.3
Roman, G.4
Terzaghi, W.5
Ecker, J.R.6
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41
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33749337753
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Possible role of light in the maintenance of EIN3/EIL1 stability in Arabidopsis seedlings
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Lee J.H., Deng X.W., and Kim W.T. Possible role of light in the maintenance of EIN3/EIL1 stability in Arabidopsis seedlings. Biochem Biophys Res Comm 350 (2006) 484-491
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Biochem Biophys Res Comm
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Lee, J.H.1
Deng, X.W.2
Kim, W.T.3
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42
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34250675590
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The Arabidopsis EIN3 binding F-box proteins EBF1 and EBF2 have distinct but overlapping roles in ethylene signaling
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In this paper, the authors elucidate different temporal roles of EBF1 and EBF2 F-box proteins, which coordinately fine-tune the regulation of EIN3/EIL1 through degradation. Kinetic analysis of hypocotyl growth rates, as well as phenotypic analysis of double mutants, revealed that EBF2 most likely acts to degrade EIN3 after EBF1 acts and after ethylene responses have been initiated. The authors also show that EIN3 and EIL1 are the predominant targets of EBF1/2.
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Binder B., Walker J., Gagne J., Emborg T., Hemmann G., Bleecker A., and Vierstra R. The Arabidopsis EIN3 binding F-box proteins EBF1 and EBF2 have distinct but overlapping roles in ethylene signaling. Plant Cell 19 (2007) 509-523. In this paper, the authors elucidate different temporal roles of EBF1 and EBF2 F-box proteins, which coordinately fine-tune the regulation of EIN3/EIL1 through degradation. Kinetic analysis of hypocotyl growth rates, as well as phenotypic analysis of double mutants, revealed that EBF2 most likely acts to degrade EIN3 after EBF1 acts and after ethylene responses have been initiated. The authors also show that EIN3 and EIL1 are the predominant targets of EBF1/2.
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(2007)
Plant Cell
, vol.19
, pp. 509-523
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Binder, B.1
Walker, J.2
Gagne, J.3
Emborg, T.4
Hemmann, G.5
Bleecker, A.6
Vierstra, R.7
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43
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39149095565
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4 signaling
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This paper identifies the components of two potential MAP kinase cascades that oppositely regulate EIN3 stability. EIN3 is stabilized when phosphorylated on a particular site by MAP kinases MPK3 and MPK6. Data from protoplasts and phenotypic analysis of mutant plants suggests that the MKK9 MAPK kinase positively regulates MPK3/6. A second MAPK phosphorylation site on EIN3 is involved in EIN3 degradation. The authors show that CTR1, a putative MAPK kinase kinase, may have a role in phosphorylation on this site.
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4 signaling. Nature 451 (2008) 789-795. This paper identifies the components of two potential MAP kinase cascades that oppositely regulate EIN3 stability. EIN3 is stabilized when phosphorylated on a particular site by MAP kinases MPK3 and MPK6. Data from protoplasts and phenotypic analysis of mutant plants suggests that the MKK9 MAPK kinase positively regulates MPK3/6. A second MAPK phosphorylation site on EIN3 is involved in EIN3 degradation. The authors show that CTR1, a putative MAPK kinase kinase, may have a role in phosphorylation on this site.
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(2008)
Nature
, vol.451
, pp. 789-795
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Yoo, S.1
Cho, Y.2
Tena, G.3
Xiong, Y.4
Sheen, J.5
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44
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0141963860
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Differential regulation of EIN3 stability by glucose and ethylene signalling in plants
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Yanagisawa S., Yoo S.-D., and Sheen J. Differential regulation of EIN3 stability by glucose and ethylene signalling in plants. Nature 425 (2003) 521-525
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(2003)
Nature
, vol.425
, pp. 521-525
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Yanagisawa, S.1
Yoo, S.-D.2
Sheen, J.3
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45
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16344390469
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Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis
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Liu Y., and Zhang S. Phosphorylation of 1-aminocyclopropane-1-carboxylic acid synthase by MPK6, a stress-responsive mitogen-activated protein kinase, induces ethylene biosynthesis in Arabidopsis. Plant Cell 16 (2004) 3386-3399
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(2004)
Plant Cell
, vol.16
, pp. 3386-3399
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Liu, Y.1
Zhang, S.2
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46
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33748600413
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ETHYLENE-INSENSITIVE5 encodes a 5′ → 3′ exoribonuclease required for regulation of the EIN3-targeting F-box proteins EBF1/2
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By map-based cloning of the EIN5 locus, the authors find that EIN5 encodes the exoribonuclease XRN4. They show that EIN5 rescues the pleiotropic phenotypes of a yeast xrn mutant and find that EBF2 transcripts, and to a lesser extent EBF1, are upregulated in the ein5 mutant background. Consequently, EIN3 protein does not accumulate in the ein5 mutant in the presence of ethylene, supporting a role for EIN5 in regulating EBF1/2 transcript levels.
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Olmedo G., Guo H., Gregory B., Nourizadeh S., Aguilar-Henonin L., Li H., An F., Guzman P., and Ecker J. ETHYLENE-INSENSITIVE5 encodes a 5′ → 3′ exoribonuclease required for regulation of the EIN3-targeting F-box proteins EBF1/2. Proc Natl Acad Sci U S A 103 (2006) 13286-13293. By map-based cloning of the EIN5 locus, the authors find that EIN5 encodes the exoribonuclease XRN4. They show that EIN5 rescues the pleiotropic phenotypes of a yeast xrn mutant and find that EBF2 transcripts, and to a lesser extent EBF1, are upregulated in the ein5 mutant background. Consequently, EIN3 protein does not accumulate in the ein5 mutant in the presence of ethylene, supporting a role for EIN5 in regulating EBF1/2 transcript levels.
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(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 13286-13293
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Olmedo, G.1
Guo, H.2
Gregory, B.3
Nourizadeh, S.4
Aguilar-Henonin, L.5
Li, H.6
An, F.7
Guzman, P.8
Ecker, J.9
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47
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33845742490
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The exoribonuclease XRN4 is a component of the ethylene response pathway in Arabidopsis
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The authors find that EIN5 and XRN4 are allelic based on complementation analysis after observing a similar increase in expression of EBF1/EBF2 in these mutants. Using kinetic analysis of hypocotyl growth rates, the authors show that the ein5-1 mutant displays a response similar to the ein3-1 mutant, suggesting that the abundance of EBF1/EBF2 transcripts in the ein5-1 background leads to more rapid EIN3 degradation. Importantly, loss of the exoribonuclease EIN5/XRN4 does not lead to more stable EBF1/EBF2 transcripts, indicating that EIN5/XRN4 does not act by degrading EBF1/2 transcripts.
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Potuschak T., Vansiri A., Binder B., Lechner E., Vierstra R., and Genschik P. The exoribonuclease XRN4 is a component of the ethylene response pathway in Arabidopsis. Plant Cell 18 (2006) 3047-3057. The authors find that EIN5 and XRN4 are allelic based on complementation analysis after observing a similar increase in expression of EBF1/EBF2 in these mutants. Using kinetic analysis of hypocotyl growth rates, the authors show that the ein5-1 mutant displays a response similar to the ein3-1 mutant, suggesting that the abundance of EBF1/EBF2 transcripts in the ein5-1 background leads to more rapid EIN3 degradation. Importantly, loss of the exoribonuclease EIN5/XRN4 does not lead to more stable EBF1/EBF2 transcripts, indicating that EIN5/XRN4 does not act by degrading EBF1/2 transcripts.
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(2006)
Plant Cell
, vol.18
, pp. 3047-3057
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Potuschak, T.1
Vansiri, A.2
Binder, B.3
Lechner, E.4
Vierstra, R.5
Genschik, P.6
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48
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0034610344
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Novel features of the XRN-family in Arabidopsis: evidence that AtXRN4, one of several orthologs of nuclear Xrn2p/Rat1p, functions in the cytoplasm
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Kastenmayer J., and Green P. Novel features of the XRN-family in Arabidopsis: evidence that AtXRN4, one of several orthologs of nuclear Xrn2p/Rat1p, functions in the cytoplasm. Proc Natl Acad Sci U S A 97 (2000) 13985-13990
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(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 13985-13990
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Kastenmayer, J.1
Green, P.2
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49
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34547679754
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Mutational loss of the prohibitin AtPHB3 results in an extreme constitutive ethylene response phenotype coupled with partial loss of ethylene-inducible gene expression in Arabidopsis seedlings
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In this paper, the authors identify EER3 as a possible component of the ethylene signaling pathway. eer3-1 was isolated in a screen for Arabidopsis seedlings with enhanced ethylene response. A second allele (a T-DNA insertion), eer3-2, confers a severe constitutive triple-response phenotype and is epistatic to ein2 and ein3 mutations. While this suggests that EER3 may be a negative regulator of ethylene responses acting downstream of EIN2, analysis of ethylene-responsive gene expression suggests that EER3 instead may act to positively regulate certain ethylene responsive genes and to promote growth in the presence of ethylene.
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Christians M.J., and Larsen P.B. Mutational loss of the prohibitin AtPHB3 results in an extreme constitutive ethylene response phenotype coupled with partial loss of ethylene-inducible gene expression in Arabidopsis seedlings. J Exp Bot 58 (2007) 2237-2248. In this paper, the authors identify EER3 as a possible component of the ethylene signaling pathway. eer3-1 was isolated in a screen for Arabidopsis seedlings with enhanced ethylene response. A second allele (a T-DNA insertion), eer3-2, confers a severe constitutive triple-response phenotype and is epistatic to ein2 and ein3 mutations. While this suggests that EER3 may be a negative regulator of ethylene responses acting downstream of EIN2, analysis of ethylene-responsive gene expression suggests that EER3 instead may act to positively regulate certain ethylene responsive genes and to promote growth in the presence of ethylene.
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(2007)
J Exp Bot
, vol.58
, pp. 2237-2248
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Christians, M.J.1
Larsen, P.B.2
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50
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34547689881
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Arabidopsis enhanced ethylene response 4 encodes an EIN3-interacting TFIID transcription factor required for proper ethylene response, including ERF1 induction
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Robles L., Wampole J., Christians M., and Larsen P. Arabidopsis enhanced ethylene response 4 encodes an EIN3-interacting TFIID transcription factor required for proper ethylene response, including ERF1 induction. J Exp Bot 58 (2007) 2627-2639
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(2007)
J Exp Bot
, vol.58
, pp. 2627-2639
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Robles, L.1
Wampole, J.2
Christians, M.3
Larsen, P.4
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51
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33646236590
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Mapping the Arabidopsis organelle proteome
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Dunkley T.P.J., Hester S., Shadforth I.P., Runions J., Weimar T., Hanton S.L., Griffin J.L., Bessant C., Brandizzi F., Hawes C., et al. Mapping the Arabidopsis organelle proteome. Proc Natl Acad Sci U S A 103 (2000) 6518-6523
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(2000)
Proc Natl Acad Sci U S A
, vol.103
, pp. 6518-6523
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Dunkley, T.P.J.1
Hester, S.2
Shadforth, I.P.3
Runions, J.4
Weimar, T.5
Hanton, S.L.6
Griffin, J.L.7
Bessant, C.8
Brandizzi, F.9
Hawes, C.10
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