Serum angiotensin converting enzyme and the obstructive sleep apnea hypopnea syndrome

Journal of Clinical Sleep Medicine

Volumn 4, Issue 4, 2008, Pages 325-331

  Benjamin, John Amit ^a   Moller, Maria ^b   Ebden, Philip ^c   Bartle, Ionah ^a   Lewis, Keir E ^a,b  

^a PRINCE PHILIP HOSPITAL   (United Kingdom)

^b SWANSEA UNIVERSITY   (United Kingdom)

^c SINGLETON HOSPITAL   (United Kingdom)

Author keywords

Angiotensin converting enzyme; CPAP; Obstructive sleep apnea

Indexed keywords

ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; AGED; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DAYTIME SOMNOLENCE; DIASTOLIC BLOOD PRESSURE; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; EPWORTH SLEEPINESS SCALE; FEMALE; GENE FREQUENCY; HEALTH CARE FACILITY; HUMAN; HYPERTENSION; INTERVENTION STUDY; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; POSITIVE END EXPIRATORY PRESSURE; SLEEP APNEA SYNDROME; SLEEP DISORDERED BREATHING; SNORING; SYSTOLIC BLOOD PRESSURE; UNITED KINGDOM;

ADULT; AGED; CONTINUOUS POSITIVE AIRWAY PRESSURE; CROSS-SECTIONAL STUDIES; ENDOTHELIUM, VASCULAR; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; PEPTIDYL-DIPEPTIDASE A; PROSPECTIVE STUDIES; SLEEP APNEA, OBSTRUCTIVE; SNORING;

EID: 51549098989     PISSN: 15509389     EISSN: 15509397     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Anonymous. Management of Obstructive Steep Apnoea/Hypopnea Syndrome in Adults. Scottish Intercollegiate Guidelines Network (SIGN) and British Thoracic Society Guidelines. 2003. Last accessed at www.sign.ac.uk, 2008.
2. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993;328:1230-5.
3. Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 2000;342:1378-84.
4. Philips B. Sleep-disordered breathing and cardiovascular disease. Sleep Med Rev 2005;9:131-40.
5. Dart RA, Gregoire JR, Gutterman DD, Woolf SH. The association of hypertension and secondary cardiovascular disease with sleep-disordered breathing. Chest 2003;123:244-60.
6. Robinson GV, Stradling JR, Davies RJ. Sleep. 6: obstructive sleep apnoea/ hypopnoea syndrome and hypertension. Thorax 2004;59:1089-94.
7. Pepperell JC, Ramdassingh-Dow S, Crosthwaite N, et al. Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial. Lancet 2002;359:204-10.
8. Robinson GV, Smith DM, Langford BA, Davies RJ, Stradling JR. Continuous positive airway pressure does not reduce blood pressure in nonsleepy hypertensive OSA patients. Eur Respir J 2006;27:1229-35.
9. Leuenberger U, Jacob E, Sweer L, Waravdekar N, Zwillich C, Sinoway L. Surges of muscle sympathetic nerve activity during obstructive apnea are linked to hypoxemia. J Appl Physiol 1995;79:581-8.
10. Hedner J, Darpo B, Ejnell H, Carlson J, Caidahl K. Reduction in sympathetic activity after long-term CPAP treatment in sleep apnoea: cardiovascular implications. Eur Respir J 1995;8:222-9.
11. Norman D, Loredo JS, Nelesen RA, et al. Effects of continuous positive airway pressure versus supplemental oxygen on 24-hour ambulatory blood pressure. Hypertension 2006;47:840-5.
12. Heitmann J, Ehlenz K, Penzel T et al. Sympathetic activity is reduced by nCPAP in hypertensive obstructive sleep apnoea patients. Eur Respir J 2004;23:255-62.
13. Erdos EG, Skidgel RA. The angiotensin I-converting enzyme. Lab Invest 1987;56:345-8.
14. Heistad DD, Lopez JA, Baumbach GL. Hemodynamic determinants of vascular changes in hypertension and atherosclerosis. Hypertension 1991;17:III7-11.
15. Cody RJ. The integrated effects of angiotensin II. Am J Cardiol 1997;79:9-11.
16. Gibbons GH. Endothelial function as a determinant of vascular function and structure: a new therapeutic target. Am J Cardiol 1997;79:3-8.
17. Carlson JT, Rangemark C, Hedner JA. Attenuated endothelium-dependent vascular relaxation in patients with sleep apnoea. J Hypertens 1996;14:577-84.
18. Cody RJ. The sympathetic nervous system and the renin-angiotensin-aldosterone system in cardiovascular disease. Am J Cardiol 1997;80:9J-14J.
19. Lewis K, Benjamin J, Ebden P, Bartle I, Griffin D. Serum angiotensin converting enzyme (ACE) and correlation with nocturnal diastolic blood pressure in patients with the sleep apnoea syndrome. Thorax 2005;60:75.
20. Barcelo A, Elorza MA, Barbe F, Santos C, Mayoralas LR, Agusti AG. Angiotensin converting enzyme in patients with sleep apnoea syndrome: plasma activity and gene polymorphisms. Eur Respir J 2001;17:728-32.
21. Holmquist B, Bunning P, Riordan JF. A continuous spectrophotometric assay for angiotensin converting enzyme. Anal Biochem 1979;95:540-8.
22. Kaneko Y, Floras JS, Usui K et al. Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med 2003;348:1233-41.
23. Jimenez PM, Conde C, Casanegra A, Romero C, Tabares AH, Orias M. Association of ACE genotype and predominantly diastolic hypertension: a preliminary study. J Renin Angiotensin Aldosterone Syst 2007;8:42-4.
24. Kretowski A, McFann K, Hokanson JE, et al. Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosis. Diabetes 2007;56:863-71.
25. Seckin D, Ilhan N, Ozbay Y. The relationship between ACE insertion/ deletion polymorphism and coronary artery disease with or without myocardial infarction. Clin Biochem 2006;39:50-4.
26. Cambien F, Poirier O, Lecerf L, et al. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 1992;359:641-4.
27. Raynolds MV, Bristow MR, Bush EW, et al. Angiotensin-converting enzyme DD genotype in patients with ischaemic or idiopathic dilated cardiomyopathy. Lancet 1993;342:1073-5.
28. Nakai K, Itoh C, Miura Y, et al. Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese. Circulation 1994;90:2199-202.
29. Schunkert H, Hense HW, Holmer SR, et al. Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N Engl J Med 1994;330:1634-8.
30. Lin L, Finn L, Zhang J, Young T, Mignot E. Angiotensin-converting enzyme, sleep-disordered breathing, and hypertension. Am J Respir Crit Care Med 2004;170:1349-53.
31. Patel SR, Larkin EK, Mignot E, Lin L, Redline S. The association of angiotensin converting enzyme (ACE) polymorphisms with sleep apnea and hypertension. Sleep 2007;30:531-3.
32. Zhang J, Zhao B, Gesongluobu, et al. Angiotensin-converting enzyme gene insertion/deletion (I/D) polymorphism in hypertensive patients with different degrees of obstructive sleep apnea. Hypertens Res 2000;23:407-11.
33. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990;86:1343-6.
34. O'Donnell CJ, Lindpaintner K, Larson MG, et al. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 1998;97:1766-72.
35. Pitt BR, Lister G, Dawson CA, Linehan JH. Effect of hypoxia and hypercapnia on ACE activity in the cerebral microcirculation of anesthetized dogs. Am J Physiol 1986;250:H806-14.
36. Zapater P, Novalbos J, Gallego-Sandin S, Hernandez FT, Abad-Santos F. Gender differences in angiotensin-converting enzyme (ACE) activity and inhibition by enalaprilat in healthy volunteers. J Cardiovasc Pharmacol 2004;43:737-44.