Cardiovascular effects of nonproteolytic activation of prorenin [5]

Hypertension

Volumn 48, Issue 6, 2006, Pages

  Susic, Dinko ^a   Lippton, Howard ^b   Knight, Martha ^b   Frohlich, Edward D ^a  

^a OCHSNER CLINIC FOUNDATION   (United States)

^b Pneumosite LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN RECEPTOR ANTAGONIST; COLLAGEN; PRORENIN; RENIN; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; GLOMERULOSCLEROSIS; HEART INJURY; HEART LEFT VENTRICLE MASS; HEART MUSCLE FIBROSIS; HEMODYNAMICS; KIDNEY INJURY; LETTER; MALE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SPONTANEOUSLY HYPERTENSIVE RAT; STREPTOZOCIN DIABETES; STROKE;

ANIMALS; CARDIOVASCULAR DISEASES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HEART; KIDNEY; KIDNEY DISEASES; MICE; PROTEINS; RATS; RENIN;

EID: 33751084042     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000247309.36509.7b     Document Type: Letter

References (5)

1. Ichihara A, Hayashi M, Kaneshiro Y, Suzuki F, Najagawa T, Tada Y, Koura Y, Nishiyama A, Okada H, Uddin MN, Nabi AH, Ishida Y, Inagami T, Saruta T. Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin. J Clin Invest. 2004;114:1128-1135.
2. Ichihara A, Suzuki F, Nakagawa T, Kaneshiro Y, Takemitsu T, Sakoda M, Nabi AH, Nishiyama A, Sugaya T, Hayashi M, Inagami T. Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice. J Am Soc Nephrol. 2006;17:1950-1961.
3. Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Suzuki F, Nakagawa T, Nishiyama A, Inagami T, Hayashi M. Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension. 2006;47:894-900.
4. Danser AHJ. Prorenin: back into the arena. Hypertension. 2006;47:824-826.
5. Kaneko K, Susic D, Nunez E, Frohlich ED. Losartan reduces cardiac mass and improves coronary flow reserve in the spontaneously hypertensive rat. J Hypertens. 1996;14:645-653.