Concentration and age-dependent elimination kinetics of polychlorinated dibenzofurans in Yucheng and Yusho patients

Toxicology and Industrial Health

Volumn 23, Issue 8, 2007, Pages 493-501

  Leung, Hw ^a   Kerger, Bd ^b   Paustenbach, Dj ^c   Ryan, Jj ^d   Masuda, Y ^e  

^a Health Science Resource Integration ^*  (United States)

^b Health Science Resource Integration   (United States)

^c CARDNO CHEMRISK   (United States)

^d HEALTH CANADA   (Canada)

^e DAIICHI UNIVERSITY OF PHARMACY   (Japan)

Author keywords

blood lipid dioxins; elimination half life; human; ingestion exposure; PCDF; pharmacokinetics; rice cooking oil

Indexed keywords

BENZOFURAN DERIVATIVE; CHLORINATED DIBENZOFURANS; VEGETABLE OIL;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; CHEMISTRY; DOSE RESPONSE; FEMALE; HALF LIFE TIME; HUMAN; JAPAN; MALE; MIDDLE AGED; RICE; SOIL POLLUTANT; TAIWAN;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; BENZOFURANS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HALF-LIFE; HUMANS; JAPAN; MALE; MIDDLE AGED; ORYZA SATIVA; PLANT OILS; SOIL POLLUTANTS; TAIWAN;

EID: 51449110336     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233708089024     Document Type: Article

References (20)

1. Aylward LL Brunet RC Carrier G. (2005a) Concentration-dependent TCDD elimination kinetics in humans: toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohort. J Expo Anal Environ Epidemiol 15: 51 – 65.
2. Aylward LL Brunet RC Starr TB. (2005b) Exposure reconstruction for the TCDD-exposed NIOSH cohort using a concentration- and age-dependent model of elimination. Risk Anal 25: 945 – 956.
3. Diggle PJ Heagerty PJ Liang K-Y Zeger SL. (2002) Analysis of longitudinal data, second ed. New York : Oxford University Press.
4. Emond C Michaelek JE Birnbaum LS DeVito MJ. (2004) Use of a PBPK model with dose-dependent elimination rates predicts higher peak dioxin exposure than previously estimated. Organohalogen Compd 66: 2655 – 2659.
5. Flesch-Janys D Becher H Gurn P. (1996) Elimination of polychlorinated dibenzo-p-dioxins and dibenzofurans in occupationally exposed persons. J Toxicol Environ Health 47: 363 – 378.
6. Geusau A Schmaldienst S Derfler K Papke O Abraham K. (2002) Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: kinetics and trials to enhance elimination in two patients. Arch Toxicol 76: 316 – 325.
7. Geyer HJ Schramm K-W Feicht EA. (2002) Half-lives of tetra-, penta-, hexa-, and octachlorodibenzo-p-dioxin in rats, monkeys, and humans—a critical review. Chemosphere 48: 631 – 644.
8. Hirakawa H Iida T Matsueda T Matsueda T Nagayama J. (1992) Concentrations and distribution of PCDDs, PCDFs and coplanar PCBs in various human tissues. Organohalogen Compd 10: 93 – 96.
9. Kerger BD Leung H-W Paustenbach DJ. (2006) Age- and concentration-dependent TCDD elimination half-life in Seveso children. Environ Health Perspect 114: 1596 – 1602.
10. Kerger BD Leung H-W Scott P Paustenbach DJ. (2007a) Refinements on the age-dependent half life model for estimating child body burdens of polychlorodibenzodioxins and dibenzofurans. Chemosphere 67: S272 – S278.
11. Kerger BD Leung H-W Scott P Paustenbach DJ. (2007b) An adaptable internal dose model for risk assessment of dietary and soil dioxin exposures in young children. Toxicol Sci. 100: 224 – 237.
12. Kreuzer PE Csanady GA Baur C. (1997) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and congeners in infants. A toxicokinetic model of human lifetime body burden by TCDD with special emphasis on its uptake by nutrition. Arch Toxicol 71: 383 – 400.
13. Leung H-W Kerger BD Paustenbach DJ. (2006) Elimination half-lives of selected polychlorinated dibenzodioxins and dibenzofurans in breast-fed human infants. J Toxicol Environ Health A 69; 437 – 443.
14. Masuda Y. (1996) Chapter 4. Causal agents in Yusho. In: M Kuratsune H Yoshimura Y Hori M Okumura Y Masuda, (eds), Yusho, a human disaster caused by PCBs and related compounds. Fukuoka, Japan : Kyushu Press, pp. 47–80.
15. Masuda Y. (2001) Fate of PCDF/PCB congeners and change of clinical symptoms in patients with Yusho PCB poisoning for 30 years. Chemosphere 43: 925 – 930.
16. Masuda Y Haraguchi K Kuroki H Ryan JJ. (2001) The changes of PCBs and PCDFs as well as symptoms in Yusho patients for 30 years. Fukuoka Acta Medica 92: 149 – 157.
17. Ryan JJ Panopio LG Lewis DA. (1991) Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in cows'milk packaged in plastic-coated bleached paperboard containers. J Agric Food Chem 39: 218 – 223.
18. Ryan JJ Levesque D Panopio LG. (1993a) Elimination of polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) from human blood in the Yusho and Yu-Cheng rice oil poisonings. Arch Environ Contam Toxicol 24: 504 – 512.
19. Ryan JJ Hsu C-C Guo YL. (1993b) Exposure of children whose mothers suffered form Yucheng poisoning to polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs). Organohalogen Compd 14: 243 – 246.
20. Schecter A Ryan JJ Kostyniak PJ. (1990) Decrease over a six year period of dioxin and dibenzofuran tissue levels in a single patient following exposure. Chemosphere 20: 911 – 917.