메뉴 건너뛰기




Volumn 29, Issue 11, 2008, Pages 1733-1743

Motor and cognitive deficits in the heterozygous leaner mouse, a Cav2.1 voltage-gated Ca2+ channel mutant

Author keywords

Calcium currents; Learning; Memory; Natural mutant; Rotarod test; Water maze test

Indexed keywords

CALCIUM CHANNEL; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL 2.1;

EID: 51449092440     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2007.04.005     Document Type: Article
Times cited : (28)

References (42)
  • 1
    • 0027745596 scopus 로고
    • Modified hippocampal long-term potentiation in PKC gamma-mutant mice
    • Abeliovich A., Chen C., Goda Y., Silva A.J., Stevens C.F., and Tonegawa S. Modified hippocampal long-term potentiation in PKC gamma-mutant mice. Cell 75 (1993) 1253-1262
    • (1993) Cell , vol.75 , pp. 1253-1262
    • Abeliovich, A.1    Chen, C.2    Goda, Y.3    Silva, A.J.4    Stevens, C.F.5    Tonegawa, S.6
  • 2
    • 0027787664 scopus 로고
    • PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning
    • Abeliovich A., Paylor R., Chen C., Kim J.J., Wehner J.M., and Tonegawa S. PKC gamma mutant mice exhibit mild deficits in spatial and contextual learning. Cell 75 (1993) 1263-1271
    • (1993) Cell , vol.75 , pp. 1263-1271
    • Abeliovich, A.1    Paylor, R.2    Chen, C.3    Kim, J.J.4    Wehner, J.M.5    Tonegawa, S.6
  • 3
    • 0031019589 scopus 로고    scopus 로고
    • Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene
    • Airaksinen M.S., Eilers J., Garaschuk O., Thoenen H., Konnerth A., and Meyer M. Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 1488-1493
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 1488-1493
    • Airaksinen, M.S.1    Eilers, J.2    Garaschuk, O.3    Thoenen, H.4    Konnerth, A.5    Meyer, M.6
  • 4
    • 0344406276 scopus 로고    scopus 로고
    • Phenotypes of spinocerebellar ataxia type 6 and familial hemiplegic migraine caused by a unique CACNA1A missense mutation in patients from a large family
    • Alonso I., Barros J., Tuna A., Coelho J., Sequeiros J., Silveira I., and Coutinho P. Phenotypes of spinocerebellar ataxia type 6 and familial hemiplegic migraine caused by a unique CACNA1A missense mutation in patients from a large family. Arch. Neurol. 60 (2003) 610-614
    • (2003) Arch. Neurol. , vol.60 , pp. 610-614
    • Alonso, I.1    Barros, J.2    Tuna, A.3    Coelho, J.4    Sequeiros, J.5    Silveira, I.6    Coutinho, P.7
  • 6
    • 0027476024 scopus 로고
    • A synaptic model of memory: long-term potentiation in the hippocampus
    • Bliss T.V., and Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361 (1993) 31-39
    • (1993) Nature , vol.361 , pp. 31-39
    • Bliss, T.V.1    Collingridge, G.L.2
  • 7
    • 0028071507 scopus 로고
    • Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein
    • Bourtchuladze R., Frenguelli B., Blendy J., Cioffi D., Schutz G., and Silva A.J. Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79 (1994) 59-68
    • (1994) Cell , vol.79 , pp. 59-68
    • Bourtchuladze, R.1    Frenguelli, B.2    Blendy, J.3    Cioffi, D.4    Schutz, G.5    Silva, A.J.6
  • 11
    • 1942543174 scopus 로고    scopus 로고
    • Altered calcium homeostasis in cerebellar Purkinje cells of leaner mutant mice
    • Dove L.S., Nahm S.S., Murchison D., Abbott L.C., and Griffith W.H. Altered calcium homeostasis in cerebellar Purkinje cells of leaner mutant mice. J. Neurophysiol. 84 (2000) 513-524
    • (2000) J. Neurophysiol. , vol.84 , pp. 513-524
    • Dove, L.S.1    Nahm, S.S.2    Murchison, D.3    Abbott, L.C.4    Griffith, W.H.5
  • 12
    • 0031064169 scopus 로고    scopus 로고
    • Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice
    • Doyle J., Ren X., Lennon G., and Stubbs L. Mutations in the Cacnl1a4 calcium channel gene are associated with seizures, cerebellar degeneration, and ataxia in tottering and leaner mutant mice. Mamm. Genome 8 (1997) 113-120
    • (1997) Mamm. Genome , vol.8 , pp. 113-120
    • Doyle, J.1    Ren, X.2    Lennon, G.3    Stubbs, L.4
  • 13
    • 0018366237 scopus 로고
    • The relationship between extracellular calcium concentrations and the induction of hippocampal long-term potentiation
    • Dunwiddie T.V., and Lynch G. The relationship between extracellular calcium concentrations and the induction of hippocampal long-term potentiation. Brain Res. 169 (1979) 103-110
    • (1979) Brain Res. , vol.169 , pp. 103-110
    • Dunwiddie, T.V.1    Lynch, G.2
  • 14
    • 0036877968 scopus 로고    scopus 로고
    • Calcium stores and synaptic plasticity
    • Fitzjohn S.M., and Collingridge G.L. Calcium stores and synaptic plasticity. Cell Calcium 32 (2002) 405-411
    • (2002) Cell Calcium , vol.32 , pp. 405-411
    • Fitzjohn, S.M.1    Collingridge, G.L.2
  • 16
    • 0037466778 scopus 로고    scopus 로고
    • Fluoro-jade identification of cerebellar granule cell and purkinje cell death in the alpha1A calcium ion channel mutant mouse, leaner
    • Frank T.C., Nunley M.C., Sons H.D., Ramon R., and Abbott L.C. Fluoro-jade identification of cerebellar granule cell and purkinje cell death in the alpha1A calcium ion channel mutant mouse, leaner. Neuroscience 118 (2003) 667-680
    • (2003) Neuroscience , vol.118 , pp. 667-680
    • Frank, T.C.1    Nunley, M.C.2    Sons, H.D.3    Ramon, R.4    Abbott, L.C.5
  • 17
    • 0025089008 scopus 로고
    • Two components of long-term potentiation induced by different patterns of afferent activation
    • Grover L.M., and Teyler T.J. Two components of long-term potentiation induced by different patterns of afferent activation. Nature 347 (1990) 477-479
    • (1990) Nature , vol.347 , pp. 477-479
    • Grover, L.M.1    Teyler, T.J.2
  • 18
    • 0035094767 scopus 로고    scopus 로고
    • A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
    • Guy J., Hendrich B., Holmes M., Martin J.E., and Bird A. A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat. Genet. 27 (2001) 322-326
    • (2001) Nat. Genet. , vol.27 , pp. 322-326
    • Guy, J.1    Hendrich, B.2    Holmes, M.3    Martin, J.E.4    Bird, A.5
  • 19
    • 0019949253 scopus 로고
    • Cerebellar cell degeneration in the leaner mutant mouse
    • Herrup K., and Wilczynski S.L. Cerebellar cell degeneration in the leaner mutant mouse. Neuroscience 7 (1982) 2185-2196
    • (1982) Neuroscience , vol.7 , pp. 2185-2196
    • Herrup, K.1    Wilczynski, S.L.2
  • 20
    • 33846299611 scopus 로고    scopus 로고
    • Characterization of acetylcholine release and the compensatory contribution of non-Ca(v)2.1 channels at motor nerve terminals of leaner Ca(v)2.1-mutant mice
    • Kaja S., van de Ven R.C., Broos L.A., Frants R.R., Ferrari M.D., van den Maagdenberg A.M., and Plomp J.J. Characterization of acetylcholine release and the compensatory contribution of non-Ca(v)2.1 channels at motor nerve terminals of leaner Ca(v)2.1-mutant mice. Neuroscience 144 (2007) 1278-1287
    • (2007) Neuroscience , vol.144 , pp. 1278-1287
    • Kaja, S.1    van de Ven, R.C.2    Broos, L.A.3    Frants, R.R.4    Ferrari, M.D.5    van den Maagdenberg, A.M.6    Plomp, J.J.7
  • 21
    • 0035929240 scopus 로고    scopus 로고
    • An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory
    • Kang H., Sun L.D., Atkins C.M., Soderling T.R., Wilson M.A., and Tonegawa S. An important role of neural activity-dependent CaMKIV signaling in the consolidation of long-term memory. Cell 106 (2001) 771-783
    • (2001) Cell , vol.106 , pp. 771-783
    • Kang, H.1    Sun, L.D.2    Atkins, C.M.3    Soderling, T.R.4    Wilson, M.A.5    Tonegawa, S.6
  • 22
    • 33846909445 scopus 로고    scopus 로고
    • Motor deficits in homozygous and heterozygous P/Q-type calcium channel mutants
    • Katoh A., Jindal J., and Raymond J. Motor deficits in homozygous and heterozygous P/Q-type calcium channel mutants. J. Neurophysiol. 97 (2007) 1280-1287
    • (2007) J. Neurophysiol. , vol.97 , pp. 1280-1287
    • Katoh, A.1    Jindal, J.2    Raymond, J.3
  • 24
    • 0032528954 scopus 로고    scopus 로고
    • Expression of calcium channel alpha1A mRNA and protein in the leaner mouse (tgla/tgla) cerebellum
    • Lau F.C., Abbott L.C., Rhyu I.J., Kim D.S., and Chin H. Expression of calcium channel alpha1A mRNA and protein in the leaner mouse (tgla/tgla) cerebellum. Brain Res. Mol. Brain Res. 59 (1998) 93-99
    • (1998) Brain Res. Mol. Brain Res. , vol.59 , pp. 93-99
    • Lau, F.C.1    Abbott, L.C.2    Rhyu, I.J.3    Kim, D.S.4    Chin, H.5
  • 25
    • 21644449434 scopus 로고    scopus 로고
    • Postnatal apoptosis in cerebellar granule cells of homozygous leaner (tg1a/tg1a) mice
    • Lau F.C., Frank T.C., Nahm S.S., Stoica G., and Abbott L.C. Postnatal apoptosis in cerebellar granule cells of homozygous leaner (tg1a/tg1a) mice. Neurotox. Res. 6 (2004) 267-280
    • (2004) Neurotox. Res. , vol.6 , pp. 267-280
    • Lau, F.C.1    Frank, T.C.2    Nahm, S.S.3    Stoica, G.4    Abbott, L.C.5
  • 27
    • 0032526434 scopus 로고    scopus 로고
    • Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner
    • Lorenzon N.M., Lutz C.M., Frankel W.N., and Beam K.G. Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner. J. Neurosci. 18 (1998) 4482-4489
    • (1998) J. Neurosci. , vol.18 , pp. 4482-4489
    • Lorenzon, N.M.1    Lutz, C.M.2    Frankel, W.N.3    Beam, K.G.4
  • 29
    • 17844389364 scopus 로고    scopus 로고
    • The wide spectrum of spinocerebellar ataxias (SCAs)
    • Manto M.U. The wide spectrum of spinocerebellar ataxias (SCAs). Cerebellum 4 (2005) 2-6
    • (2005) Cerebellum , vol.4 , pp. 2-6
    • Manto, M.U.1
  • 31
    • 0015116941 scopus 로고
    • Three syndromes produced by two mutant genes in the mouse. Clinical, pathological, and ultrastructural bases of tottering, leaner, and heterozygous mice
    • Meier H., and MacPike A.D. Three syndromes produced by two mutant genes in the mouse. Clinical, pathological, and ultrastructural bases of tottering, leaner, and heterozygous mice. J. Hered. 62 (1971) 297-302
    • (1971) J. Hered. , vol.62 , pp. 297-302
    • Meier, H.1    MacPike, A.D.2
  • 34
    • 0042233504 scopus 로고    scopus 로고
    • 'New' functions for 'old' proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice
    • Schwaller B., Meyer M., and Schiffmann S. 'New' functions for 'old' proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice. Cerebellum 1 (2002) 241-258
    • (2002) Cerebellum , vol.1 , pp. 241-258
    • Schwaller, B.1    Meyer, M.2    Schiffmann, S.3
  • 36
    • 0015019475 scopus 로고
    • Evidence for allelism of leaner and tottering in the mouse
    • Tsuji S., and Meier H. Evidence for allelism of leaner and tottering in the mouse. Genet. Res. 17 (1971) 83-88
    • (1971) Genet. Res. , vol.17 , pp. 83-88
    • Tsuji, S.1    Meier, H.2
  • 39
    • 0037379663 scopus 로고    scopus 로고
    • Modelling brain diseases in mice: the challenges of design and analysis
    • Watase K., and Zoghbi H.Y. Modelling brain diseases in mice: the challenges of design and analysis. Nat. Rev. Genet. 4 (2003) 296-307
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 296-307
    • Watase, K.1    Zoghbi, H.Y.2
  • 40
    • 11244352125 scopus 로고    scopus 로고
    • Oligosyndactylism mice have an inversion of chromosome 8
    • Wise T.L., and Pravtcheva D.D. Oligosyndactylism mice have an inversion of chromosome 8. Genetics 168 (2004) 2099-2112
    • (2004) Genetics , vol.168 , pp. 2099-2112
    • Wise, T.L.1    Pravtcheva, D.D.2
  • 42
    • 0035866087 scopus 로고    scopus 로고
    • Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a
    • Zwingman T.A., Neumann P.E., Noebels J.L., and Herrup K. Rocker is a new variant of the voltage-dependent calcium channel gene Cacna1a. J. Neurosci. 21 (2001) 1169-1178
    • (2001) J. Neurosci. , vol.21 , pp. 1169-1178
    • Zwingman, T.A.1    Neumann, P.E.2    Noebels, J.L.3    Herrup, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.