LEAPT: Lectin-directed enzyme-activated prodrug therapy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 40, 2004, Pages 14527-14532

  Robinson, Mark A ^a   Charlton, Stuart T ^b   Garnier, Philippe ^a   Wang, Xiang Tao ^a   Davis, Stanley S ^b   Perkins, Alan C ^c   Frier, Malcolm ^c   Duncan, Ruth ^d   Savage, Tony J ^e   Wyatt, David A ^e   Watson, Susan A ^b   Davis, Benjamin G ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c QUEEN S MEDICAL CENTRE   (United Kingdom)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOHYDRATE; DOXORUBICIN ALPHA PYRANOSIDASE; ENZYME; HYMECROMONE; LECTIN; MENDIAXON ALPHA RHAMNOPYRANOSIDE; NARINGINASE DEGLYCOSYLATED GALACTOSE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING COMPETITION; CANCER MODEL; CARBOHYDRATE ANALYSIS; CELL TYPE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONJUGATE; CONTROLLED STUDY; DEGLYCOSYLATION; DRUG ACTIVATION; DRUG BINDING SITE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG LIVER LEVEL; DRUG RELEASE; DRUG SYNTHESIS; DRUG THERAPY; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME GLYCOSYLATION; ENZYME LOCALIZATION; ENZYME STABILITY; ENZYME STRUCTURE; GAMMA SCINTIGRAPHY; IN VIVO STUDY; LECTIN BINDING; LECTIN DIRECTED ENZYME ACTIVATED PRODRUG THERAPY; LIGAND BINDING; LIVER CELL; LIVER CELL CARCINOMA; MALE; NONHUMAN; ORGAN DISTRIBUTION; PRIORITY JOURNAL; PROTEIN ENGINEERING; RABBIT; TARGET CELL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; DOXORUBICIN; DRUG DELIVERY SYSTEMS; ENZYME ACTIVATION; ENZYME STABILITY; GLYCOSIDE HYDROLASES; GLYCOSYLATION; HUMANS; KIDNEY; LECTINS; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, NUDE; PRODRUGS; PROTEIN ENGINEERING; RABBITS; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 5144232846     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0303574101     Document Type: Article

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