Zinc coupling potentiates anti-HIV-1 activity of baicalin

Biochemical and Biophysical Research Communications

Volumn 324, Issue 2, 2004, Pages 605-610

  Wang, Qian ^a,b   Wang, Yu Tian ^c   Pu, Shao Ping ^c   Zheng, Yong Tang ^a  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b KUNMING INSTITUTE OF PRECIOUS METALS   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Anti HIV activity; Baicalin; HIV entry; HIV 1; RT; Zinc

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BAICALIN; BAICALIN ZINC COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; UNCLASSIFIED DRUG; ZINC COMPLEX;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG EFFECT; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; SYNCYTIUM;

ANTI-HIV AGENTS; CELL LINE; COLORING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLAVONOIDS; HIV CORE PROTEIN P24; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MODELS, CHEMICAL; RECOMBINANT PROTEINS; T-LYMPHOCYTES; TETRAZOLIUM SALTS; THIAZOLES; TIME FACTORS; ZINC;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 5144232449     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.09.093     Document Type: Article

References (28)

1. K. Kitamura, M. Honda, H. Yoshizaki, S. Yamamoto, H. Nakane, M. Fukushima, K. Ono, and T. Tokunaga Baicalinin, an inhibitor of HIV-1 production vitro Antiviral Res. 37 1998 131 140
2. J. Zhao, Z.P. Zhang, H.S. Chen, X.Q. Zhang, and X.H. Chen Synthesis of Baicalin derivatives and evaluation of their anti-human immunodeficiency virus (HIV-1) activity Acta Pharm. Sin. 33 1998 22 27
3. J. Zhao, Z.P. Zhang, H.S. Chen, X.H. Chen, and X.Q. Zhang Preparation and anti HIV activity study of Baicalien and its benzylated derivatives Acta Pharm. Sin. 32 1997 140 143
4. B.Q. Li, T. Fu, Y. Dongyan, J.A. Mikovits, F.W. Ruscetti, and J.M. Wang Flavonoid Baicalin inhibits HIV-1 infection at the level of viral entry Biochem. Biophys. Res. Commun. 276 2000 534 538
5. E. De Clercq Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection Med. Res. Rev. 20 2000 323 349
6. I. Neves Jr., A.L. Bertho, V.G. Veloso, D.V. Nascimento, D.L.A. Campos-Mello, and M.G. Morgado Improvement of the lymphoproliferative immune response and apoptosis inhibition upon in vitro treatment with zinc of peripheral blood mononuclear cells (PBMC) from HIV+ individuals Clin. Exp. Immunol. 111 1998 264 268
7. Y. Haraguchi, H. Sakurai, S. Hussain, B.M. Anner, and H. Hoshino Inhibition of HIV-1 infection by zinc group metal compounds Antiviral Res. 43 1999 123 133
8. N. Takamune, S. Misumi, and S. Shoji Cyclic zinc-dithiocarbamate-S, S′-dioxide blocks CXCR4-mediated HIV-1 infection Biochem. Biophys. Res. Commun. 272 2000 351 356
9. Y. Inouye, T. Kanamori, T. Yoshida, X.H. Bu, M. Shionoya, T. Koike, and E. Kimura Inhibition of human immunodeficiency virus proliferation by macrocyclic polyamines and their metal complexes Biol. Pharm. Bull. 17 1994 243 250
10. Y. Inouye, T. Kanamori, T. Yoshida, T. Koike, M. Shionoya, H. Fujioka, and E. Kimura Differential contribution of metal complexation and dimerization to the chemotherapeutic potential of bicyclenâ€"Zn II complex against human immunodeficiency virus Biol. Pharm. Bull. 19 1996 456 458
11. Y.T. Zheng, W.F. Zhang, K.L. Ben, and J.H. Wang In vitro immunotoxicity and cytotoxicity of trichosanthin against human normal immunocytes and leukemiaâ€"lymphoma cells Immunopharmacol. Immunotoxicol. 17 1995 69 79
12. J.H. Wang, S.C. Tam, H. Huang, D.Y. Ouyang, Y.Y. Wang, and Y.T. Zheng Site-directed PEGylation of trichosanthin retained its anti-HIV activity with reduces potency in vitro Biochem. Biophys. Res. Commun. 317 2004 965 971
13. X. Liang, M. Weishapl, J.A. Parkinson, S. Parsons, P.A. McGregor, and P.J. Sadler Selective recognition of configurational substates of zinc cyclam by carboxylates: implications for the design and mechanism of action of anti-HIV agents Chem. Eur. J. 9 2003 4709 4717
14. X. Liang, J.A. Parkinson, M. Weishaupl, R.O. Gould, S.J. Paisey, H.S. Park, T.M. Hunter, C.A. Blindauer, S. Parsons, and P.J. Sadler Structure and dynamics of metallomacrocycles: recognition of zinc xylyl-bicyclam by an HIV coreceptor J. Am. Chem. Soc. 124 2002 9105 9112
15. E. De Clercq The role of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection Antiviral Res. 38 1998 153 179
16. M. Lapadat-Tapolsky, C. Gabus, M. Rau, and J.L. Darlix Possible roles of HIV-1nucleocapsid protein in the specificity of proviral DNA synthesis and in its variability J. Mol. Biol. 268 1997 250 260
17. Y. Zhang, and E. Barklis Nucleocapsid protein effects on the specificity of retrovirus RNA encapsidation J. Virol. 69 1995 5716 5722
18. L. Dawson, and X.F. Yu The role of nucleocapsid of HIV-1 in virus assembly Virology 251 1998 141 157
19. Y. Mely, H. De Rocquigny, N. Morellet, B.P. Roques, and D. Gerard Zinc binding to the HIV-1 nucleocapsid protein: a thermodynamic investigation by fluorescence spectroscopy Biochemistry 35 1996 5175 5182
20. 2+ dissociation Biochemistry 41 2002 4312 4320
21. W.G. Rice, C.A. Schaeffer, B. Harten, F. Villinger, T.L. South, M.F. Summers, L.E. Henderson, J.W. Bess, L.O. Arthur, J.S. McDougal, S.L. Orloff, J. Mendeleyev, and E. Kun Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds Nature 361 1993 473 475
22. N.B. McDnnell, R.N. De Guzman, W.G. Rice, J.A. Turpin, and M.F. Summers Zinc ejection as a new rationale for the use of cystamine and related disulfide-containing antiviral agents in the treatment of AIDS J. Med. Chem. 40 1997 1969 1976
23. P.J. Tummino, P.F. Harvey, T. Mcquade, J. Domagala, R. Gogliotti, J. Sanchez, Y. Song, and D. Hupe The human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein zinc ejection activity of disulfide benzamides and benzisothiazolones: correlation with anti-HIV and virucidal activities Antimicrob. Agents Chemother. 41 1997 394 400
24. S. Druillennec, A. Caneparo, H. de Rocquigny, and B.P. Roques Evidence of interactions between the nucleocapsid protein NCp7 and the reverse transcriptase of HIV-1 J. Biol. Chem. 274 1999 11283 11288
25. H.W. Huang, and K.T. Wang Structural characterization of the metal binding site in the cysteine-rich region of HIV-1 Tat protein Biochem. Biophys. Res. Commun. 227 1996 615 621
26. M.E. Garber, P. Wei, V.N. KewalRamani, T.P. Mayall, C.H. Hermann, A.P. Rice, D.R. Littman, and K.A. Jones The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cystein residue that is not conserved in the murine CycT1 protein Genes Dev. 12 1998 3511 3526
27. N. Wellinghausen, W.V. Kern, W. Jochle, and P. Kern Zinc serum level in human immunodeficiency virus-infected patients in relation to immunological status Biol. Trace Elem. Res. 73 2000 139 149
28. E. Mocchegiani, and M. Muzzioli Therapeutic application of zinc in human immunodeficiency virus against opportunistic infections J. Nutr. 130 2000 1424S 1431S