Environmental enrichment facilitates amygdala kindling but reduces kindling-induced fear in male rats

Behavioral Neuroscience

Volumn 118, Issue 5, 2004, Pages 1128-1133

  Young, Nicole A ^a   Wintink, Amanda J ^a   Kalynchuk, Lisa E ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMYGDALOID NUCLEUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL HOUSING; ARTICLE; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; ENVIRONMENTAL ENRICHMENT; FEAR; KINDLING; MALE; NONHUMAN; OPEN FIELD TEST; RAT; WEANING;

AMYGDALA; ANIMALS; ENVIRONMENT; FEAR; KINDLING, NEUROLOGIC; MALE; RATS; RATS, LONG-EVANS; SOCIAL ISOLATION;

EID: 5144228751     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.118.5.1128     Document Type: Article

References (38)

1. Archer, J. (1975). Rodent sex differences in the emotional and related behavior. Behavioral Biology, 14, 451-479.
2. Auvergne, R., Lere, C., El Bahh, B., Arthaud, S., Lespinet, V., Rougier, A., & Le Gal La Salle, G. (2002). Delayed kindling epileptogenesis and increased neurogenesis in adult rats housed in an enriched environment. Brain Research, 954, 277-285.
3. Babcock, A. M., Wright, J., Bjerkness, D., Hartman, H., & Tall Bear, N. (2002). Effects of prior apparatus experience and novelty of testing environment on locomotor activity following MK-801. Physiology & Behavior, 77, 177-181.
4. Depaulis, A., Helfer, V., Deransart, C., & Marescaux, C. (1997). Anxiogenic-like consequences in animal models of complex partial seizures. Neuroscience & Biobehavioral Reviews, 21, 767-774.
5. Ernfors, P., Bengzon, J., Kokaia, Z., Persson, H., & Lindvall, O. (1991). Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis. Neuron, 7, 165-176.
6. Falkenberg, T., Mohammed, A. K., & Henriksson, B. (1992). Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment. Neuroscience Letters, 138, 153-156.
7. Farrell, R., Evans, S., & Corbett, D. (2001). Environment enrichment enhances recovery of function but exacerbates ischemic cell death. Neuroscience, 107, 585-592.
8. Fernandez-Teruel, A., Gimenez-Llort, L., Escorihuela, R. M., Gil, L., Aguilar, R., Steimer, T., & Tobena, A. (2002). Early-life handling stimulation and environmental enrichment. Are some of their effects mediated by similar neural mechanisms? Pharmacology Biochemistry and Behavior, 73, 233-245.
9. Goddard, G. V. (1964). Amygdaloid stimulation and learning in the rat. Journal of Comparative Physiological Psychology, 58, 23-30.
10. Goddard, G. V., McIntyre, D. C., & Leech, C. K. (1969). A permanent change in brain function resulting from daily electrical stimulation. Experimental Neurology, 25, 295-330.
11. Green, E. J., Greenough, W. T., & Schlumpf, B. E. (1983). Effects of complex or isolated environments on cortical dendrites of middle-aged rats. Brain Research, 264, 233-240.
12. Hannesson, D. K. & Corcoran, M. E. (2000). The mnemonic effects of kindling. Neuroscience and Biobehavioral Reviews, 24, 725-751.
13. Kalynchuk, L. E. (2000). Long-term amygdala kindling in rats as a model for the study of interictal emotionality in temporal lobe epilepsy. Neuroscience & Biobehavioral Reviews, 24, 691-704.
14. Kalynchuk, L. E., Davis, A. C., Gregus, A., Taggart, J., Dodd, C. C., Wintink, A. J., & Marchant, E. G. (2001). Hippocampal involvement in the expression of kindling-induced fear in rats. Neuroscience & Biobehavioral Reviews, 25, 687-696.
15. Kalynchuk, L. E., Pinel, J. P. J., Treit, D., & Kippin, T. E. (1997). Changes in emotional behavior produced by long-term amygdala kindling in rats. Biological Psychiatry, 41, 438-451.
16. Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998). Experience-induced neurogenesis in the senescent dentate gyrus. Journal of Neuroscience, 18, 3206-3212.
17. Lee, A. W., & Kalynchuk, L. E. (2002, June). Effect of postnatal handling on the emotional behavior of adult amygdala-kindled rats. Paper presented at the International Behavioral Neuroscience Society Annual Meeting, Capri, Italy.
18. Mar, A., Spreekmeester, E., & Rochford, J. (2002). Fluoxetine-induced increases in open-field habituation in the olfactory bulbectomized rat depend on test aversiveness but not on anxiety. Pharmacology Biochemistry and Behavior, 73, 703-712.
19. Mohammed, A. H., Zhu, S. W., Darmopil, S., Hjerling-Leffler, J., Ernfors, P., Winblad, B., Diamond, M. C., Eriksson, P. S., & Bogdanovic, N. (2002). Environment and the brain. Progress in Brain Research, 138, 109-133.
20. Mohapel, P., & McIntyre, D. C. (1998). Amygdala kindling-resistant (SLOW) or -prone (FAST) rat strains show differential fear responses. Behavioral Neuroscience, 112, 1402-1413.
21. Murphy, P., & Burnham, W. M. (2003). The effect of kindled seizures on the locomotor behavior of Long-Evans rats. Experimental Neurology, 180, 87-91.
22. Parent, J. M., Janumpali, S., McNamara, J. O., & Lowenstein, D. H. (1998). Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat. Neuroscience Letters, 247, 9-12.
23. Passineau, M. J., Green, E. J., & Dietrich, W. D. (2001). Therapeutic effects of environmental enrichment on cognitive function and tissue integrity following severe traumatic brain injury in rats. Experimental Neurology, 168, 373-384.
24. Paxinos, G., & Watson, C. (1998). The rat brain in stereotaxic coordinates (4th ed.). Sydney: Academic Press.
25. Pham, T. M., Winblad, B., Granholm, A., & Mohammed, A. H. (2002). Environmental influences on brain neurotrophins in rats. Pharmacology Biochemistry and Behavior, 73, 167-175.
26. Pinel, J. P. J., & Rovner, L. I. (1978). Experimental epileptogenesis: Kindling-induced epilepsy in rats. Experimental Neurology, 58, 190-202.
27. Racine, R. J. (1972). Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalography and Clinical Neurophysiology, 32, 281-294.
28. Reibel, S., Larmet, Y., Le, B. T., Carnahan, J., Marescaux, C., & Depaulis, A. (2000). Brain-derived neurotrophic factor delays hippocampal kindling in the rat. Neuroscience, 100, 777-788.
29. Rice, A. C., & DeLorenzo, R. J. (1998). Kindling induces long-term changes in gene expression. In M. Corcoran & S. Moshe (Eds.), Kindling 5 (pp. 267-284). New York: Plenum Press.
30. Scharfman, H. E. (2002). Epilepsy as an example of neural plasticity. Neuroscientist, 8, 155-174.
31. Scott, B. W., Wang, S., Burnham, W. M., De Boni, U., & Wojtowicz, J. M. (1998). Kindling-induced neurogenesis in the dentate gyrus of the rat. Neuroscience Letters, 248, 73-76.
32. Silva-Gomez, A. B., Bermudez, M., Quirion, R., Srivastava, L. K., Picazo, O., & Flores, G. (2003). Comparative behavioral changes between male and female postpubertal rats following neonatal excitotoxic lesions of the ventral hippocampus. Brain Research, 973, 285-292.
33. Sutula, T., He, X. X., Cavazos, J., & Scott, G. (1988, March 4). Synaptic reorganization in the hippocampus induced by abnormal functional activity. Science, 239, 1147-1150.
34. Van Praag, H., Kempermann, G., & Gage, F. (2000). Neural consequences of environmental enrichment. Nature Reviews Neuroscience, 1, 191-198.
35. Walsh, R. N., & Cummins, R. A. (1976). The open-field test: A critical review. Psychological Bulletin, 3, 482-504.
36. Wintink, A. J., Young, N. A., Davis, A. C., Gregus, A., & Kalynchuk, L. E. (2003). Kindling-induced emotional behavior in male and female rats. Behavioral Neuroscience, 117, 632-640.
37. Wintink, A. J., Young, N. A., & Kalynchuk, L. E. (2002). Environmental enrichment facilitates the development of amygdala kindling in rats [Abstract]. (Poster session presented at the annual meeting of the Society for Neuroscience, Program No. 600.14). Retrieved from http://www .sfn.scholarone.com/2002itin.index.html
38. Young, D., Lawlor, P. A., Leone, P., Dragunow, M., & During, M. J. (1999). Environmental enrichment inhibits spontaneous apoptosis, prevents seizures, and is neuroprotective. Nature Medicine, 5, 448-453.