Multivalent scFv display of phagemid repertoires for the selection of carbohydrate-specific antibodies and its application to the Thomsen-Friedenreich antigen

Journal of Molecular Biology

Volumn 343, Issue 4, 2004, Pages 985-996

  Ravn, Peter ^a,b,c   Danielczyk, Antje ^c   Bak Jensen, Kim ^a,d   Kristensen, Peter ^d   Astrup Christensen, Peter ^a   Larsen, Martin ^a,b   Karsten, Uwe ^a,b   Goletz, Steffen ^a,c,e  

^a NEMOD Biotherapeutics GmbH Co KG   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c GLYCOTOPE GMBH   (Germany)

^d AARHUS UNIVERSITY   (Denmark)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

antibody engineering; multivalent scFv; phage display; Thomsen Friedenreich antigen; tumor targeting

Indexed keywords

AMINO ACID; ASIALOGLYCOPROTEIN; CARBOHYDRATE ANTIGEN; CARRIER PROTEIN; DISACCHARIDE; EPITOPE; GLYCOPHORIN; RECOMBINANT ANTIBODY; TETRAMER; THOMSEN FRIEDENREICH ANTIGEN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ANTIGEN EXPRESSION; ARTICLE; BINDING AFFINITY; CANCER IMMUNOTHERAPY; CARBOHYDRATE ANALYSIS; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE LIBRARY; GENE STRUCTURE; GENE TARGETING; IMMUNIZATION; IMMUNOHISTOCHEMISTRY; IMMUNOPHARMACOLOGY; MOUSE; NONHUMAN; PHAGE DISPLAY; PHAGEMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; TUMOR CELL;

EID: 5144226696     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.08.052     Document Type: Article

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