Mucins (MUC1 and MUC3) of gastrointestinal and breast epithelia reveal different and heterogeneous tumor-associated aberrations in glycosylation

Journal of Histochemistry and Cytochemistry

Volumn 45, Issue 11, 1997, Pages 1547-1557

  Cao, Yi ^a   Blohm, Dietmar ^b   Ghadimi, B Michael ^c   Stosiek, Peter ^d   Xing, Pei Xiang ^e   Karsten, Uwe ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b UNIVERSITY OF BREMEN   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

^d CARL THIEM KLINIKUM   (Germany)

^e AUSTIN RESEARCH INSTITUTE   (Australia)

Author keywords

Breast; Carbohydrate; Gastrointestinal tract; Immunohistochemistry; In situ hybridization; MUC1; MUC3; Periodate oxidation; Tumor

Indexed keywords

ALPHA LEVO FUCOSIDASE; GLYCAN; MESSENGER RNA; MUCIN; PERIODATE; SIALIDASE;

ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; BREAST EPITHELIUM; BREAST TUMOR; CARCINOGENESIS; COLON ADENOMA; COLORECTAL TUMOR; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTESTINE EPITHELIUM; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; RECTUM ADENOMA; TISSUE SECTION;

EID: 0030680989     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215549704501111     Document Type: Article

References (52)

1. Apostolopoulos V, McKenzie IFC (1994) Cellular mucins: targets fur immunotherapy. Crit Rev Immunol 14:293-309
2. Apostolopoulos V, Xing PX, McKenzie IFC (1995) Anti peptide monoclonal antibodies to intestinal mucin 3. J Gastroenterol Hepatol 10:555-561
3. Audie JP, Janin A, Porchet N, Copin MC, Gosselin B, Aubert JP (1993) Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization. J Histochem Cytochem 41:1479-1485
4. Bara J, Decaens C, Loridon-Rosa B, Oriol R (1992) Immunohistological characterization of mucin epitopes by pre-treatment of gastro-intestinal sections with periodic acid. J Immunol Methods 149:105-113
5. Bara J, Imberty A, Pérez S, Imai K, Yachi A, Oriol R (1993) A fucose residue can mask the MUC-1 epitopes in normal and cancerous gastric mucosae. Int J Cancer 54:607-613
6. Burchell J, Gendler S, Taylor-Papadimitriou J, Girling A, Lewis A, Millis R, Lamport D (1987) Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin. Cancer Res 47:5476-5482
7. Burchell J, Taylor-Papadimitriou J, Boshell M, Gendler S, Duhig T (1989) A short sequence, within the amino acid tandem repeat of a cancer-associated mucin, contains immunodominant epitopes. Int J Cancer 44: 691-696
8. Carrato C, Balague C, Bolos CD, Gonzalez E, Gambus G, Planas J, Perini JM, Andreu D, Real FX (1994) Differential apomucin expression in normal and neoplastic human gastrointestinal tissues. Gastroenterology 107:160-172
9. Cao Y, Karsten U, Hilgers J (1997a) TD-4 Workshop (Group #9): immunohistochemical characterization of a panel of 56 antibodies with normal human small intestine, colon, and breast tissues. Tumor Biol, in press
10. Cao Y, Karsten U, Liebrich W, Haensch W, Springer GF, Schlag P (1995) Expression of Thomsen-Friedenreich-related antigens in primary and metastatic colorectal carcinomas: a reevaluation. Cancer 76:1700-1708
11. Cao Y, Schlag PM, Karsten U (1997b) Immunodetection of epithelial mucin (MUC1, MUC3) and mucin-associated glycotopes (TF, Tn, and Sialosyl-Tn) in benign and malignant lesions of co-lon epithelium: apolar localization correspond to the malignant transformation. Virchows Arch, in press
12. Cao Y, Stosiek P, Springer GF, Karsten U (1996) Thomsen-Friedenreich-related carbohydrate antigens in normal adult human tissues: a systematic and comparative study. Histochem Oil Biol 106:197-207
13. Chang S-K, Dohrman AF, Basbaum CB, Ho SB, Tsuda T, Toribara NW, Gum JR, Kim YS (1994) Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer. Gastroenterology 107:28-36
14. Devine PL, McKenzie IFC (1992) Mucins: structure, function, and associations with malignancy. BioEssays 14:619-625
15. Elston CW, Ellis IO (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19:403-410
16. Gimmi CD, Morrinson BW, Mainprice BA, Gribben JG, Boussiotis VA, Freeman GJ, Park SYL, Watanabe M, Gong J, Hayes DF, Kufe DW, Nadler LM (1996) Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells. Nature Med 2:1367-1370
17. Girling A, Bartkova J, Burchell J, Gendler S, Gillett C, Taylor-Papadimitriou J (1989) A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas. Int J Cancer 43:1072-1076
18. Graham RA, Burchell JM, Taylor-Papadimitriou J (1996) The polymorphic epithelial mucin: potential as an immunogen for a cancer vaccine. Cancer Immunol Immunother 42:71-80
19. Gum JR, Hicks JW, Swallow DM, Lagace RE, Byrd JC, Lamport DTA, Siddiki B, Kim YS (1990) Molecular cloning of CDNAs derived from a novel human intestinal mucin gene. Biochem Biophys Res Commun 171:407-415
20. Hareuveni M, Tsarfaty I, Zaretsky J, Kotkes P, Horev J, Zrihan S, Weiss M, Green S, Lathe R, Kydar I, Wreschner DH (1990) A transcribed gene, containing a variable number of tandem repeats, codes for a human epithelial tumor antigen. cDNA cloning, expression of the transfected gene and over-expression in breast cancer tissue. Eur J Biochem 189:475-486
21. Hilkens J, Ligtenberg MJL, Vos HL, Litvinov SV (1992) Cell membrane-associated mucins and their adhesion-modulating property. Trends Biol Sci 17:359-363
22. Hilkens J, Vos HL, Wesseling J, Boer M, Storm J, van der Valk S, Calafat J, Patriarca C (1995) Is episialm/MUC1 involved in breast cancer progression? Cancer Lett 90:27-33
23. Ho JJL, Cheng S, Kim YS (1995) Access to peptide regions of a surface mucin (MUC1) is reduced by sialic acids. Biochem Biophys Res Commun 210:866-873
24. Ho SB, Ewing SL, Montgomery CK, Kim YS (1996) Altered mucin core peptide immunoreactivity in the colon polyp-carcinoma sequence. Oncol Res 8:53-61
25. Ho SB, Niehans GA, Lyftogt C, Yan PS, Cherwitz DL, Gum ET, Dahiya R, Kim YS (1993) Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res 53:641-651
26. Jass JR, Roberton AM (1994) Colorectal mucin histochemistry in health and disease: a critical review. Pathol Int 44:487-504
27. Jass JR, Sohin LH (1989) Histological Typing of Intestinal Tumours. 2nd ed. Berlin, Springer-Verlag
28. Jentoft N (1990) Why are proteins O-glycosylated? Trends Biol Sci 15:291-294
29. Karsten U, Butschak G, Cao Y, Goletz S, Hanisch F-G (1995) A new monoclonal antibody (A78-G/A7) to the Thomsen-Friedenreich pan-tumor antigen. Hybridoma 14:37-44
30. Karsten U, Pilgrim G, Hanisch F-G, Uhlenhruck G, Kasper M, Stosiek P, Papsdorf G, Pasternak G (1988) A new monoclonal antibody (A46-B/B10) highly specific for the blood group H type 2 epitope: generation, epitope analysis, scrological and histological evaluation. Br J Cancer 58:176-181
31. King M-J, Chan A, Roe R, Warren BF, Dell A, Morris HR, Bartolo DCC, Durdey P, Corfield AP (1994) Two different glycosyltransferase defects that result in GalNAcα-O-peptide (Tn) expression. Glycobiology 4:267-279
32. Konishi F, Morson BC (1982) Pathology of colorectal adenomas: a colonoscopic survey. J Clin Pathol 35:830-841
33. Kozarsky K, Kingsley D, Krieger M (1988) Use of a mutant cell line to study the kinetics and function of O-linked glycosylation of low density lipoprotein receptors. Proc Natl Acad Sci USA 85:4335-4339
34. Nakamori S, Ota DM, Cleary KR, Shirotani K, Irimura T (1994) MUC1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma. Gastroenterology 106: 53-361
35. Ogata S, Uehara H, Chen A, Itzkowitz SH (1992) Mucin gene expression in colonic tissues and cell lines. Cancer Res 52:5971-5978
36. Patton S, Gendler SJ, Spicer AP (1995) The epithelial mucin, MUC1, of milk, mammary gland and other tissues. Biochim Biophys Acta 1241:407-424
37. Podolsky DK (1985) Oligosaccharide structures of human colonic mucin. J Biol Chem 260:8262-8271
38. Regimbald LH, Pilarski LM, Longenecker BM, Reddish MA, Zimmermann G, Hugh JC (1996) The breast mucin MUC1 as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer. Cancer Res 56:4244-4249
39. Schaeren-Wiemers N, Gerfin-Moser A (1993) A simple protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry 100:431-440
40. Schwartz B, Bresalier RS, Kim YS (1992) The role of mucin in colon-cancer metastasis. Int J Cancer 52:60-65
41. Siddiqui J, Abe M, Hayes D, Shani E, Yunis E, Kufe D (1988) Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen. Proc Natl Acad Sci USA 85:2320-2323
42. Spiro RG (1966) Characterization of carbohydrate units of glycoproteins. Methods Enzymol 8:26-52
43. Strous GJ, Dekker J (1992) Mucin-type glycoproteins. Crit Rev Biochem Mol Biol 27:57-92
44. Swallow D, Gendler S, Griffiths B, Corney G, Taylor-Papadimitriou J, Bramwell ME (1987) The human tumour-associated epithelial mucins are coded by an expressed hypervariable gene locus PUM. Nature 328:82-84
45. Taylor-Papadimitriou J, Epenetos AA (1994) Exploiting altered glycosylation patterns in cancer: progress and challenges in diagnosis and therapy. Trends Biotechnol 12:227-233
46. Vavasseur F, Dole K, Yang J-M, Matta KL, Myerscough N, Corfield A, Paraskeva C, Brockhausen I (1994) O-glycan biosynthesis in human colorectal adenoma cells during progression to cancer. Eur J Biochem 222:415-424
47. Weiss AA, Babyatsky MW, Ogata S, Chen A, Itzkowitz SH (1996) Expression of MUC2 and MUC3 mRNA in human normal, malignant, and inflammatory intestinal tissues. J Histochem Cytochem 44:1161-1166
48. Woodward MP, Young WW Jr, Bloodgood RA (1985) Detection of monoclonal antibodies specific for carbohydrate epitopes using penodate oxidation. J Immunol Methods 78:143-153
49. World Health Organization (1982) The World Health Organization histological typing of breast tumors - second edition. Am J Clin Pathol 78:806-816
50. Xing PX, Apostolopoulos V, Trapani J, Prenzoska J, McKenzie IFC (1994) Peptide epitopes in breast cancer mucins. Adv Exp Med Biol 353:9-16
51. Yang J-M, Byrd JC, Siddiki BB, Chung Y-S, Okuno M, Sowa M, Kim YS, Matta KL, Brockhausen I (1994). Alterations of O-glycan biosynthesis in human colon tissues. Glycobiology 4:873-884
52. Zotter S, Hageman PC, Lossnitzer A, Mooi WJ, Hilgers J (1988) Tissue and tumor distribution of human polymorphic epithelial mucin. Cancer Rev 11-12:55-101