Bisoprolol vs. carvedilol in elderly patients with heart failure: Rationale and design of the CIBIS-ELD trial

Clinical Research in Cardiology

Volumn 97, Issue 9, 2008, Pages 578-586

  Düngen, Hans Dirk ^a   Apostolović, Svetlana ^b   Inkrot, Simone ^a   Tahirović, Elvis ^a   Krackhardt, Florian ^a   Pavlović, Milan ^b   Putniković, Biljana ^c   Lainščak, Mitja ^d   Gelbrich, Götz ^e   Edelmann, Frank ^f   Wachter, Rolf ^f   Eschenhagen, Thomas ^g   Waagstein, Finn ^h   Follath, Ferenc ⁱ   Rauchhaus, Mathias ^a   Haverkamp, Wilhelm ^a   Osterziel, Karl Josef ^j   Dietz, Rainer ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Clinical Center Ni   (Serbia)

^c Clinical Hospital Center Zemun   (Serbia)

^d University Clinic of Pulmonary and Allergic Diseases   (Slovenia)

^e Coordination Center for Clinical Trials Leipzig ^*  (Germany)

^f UNIVERSITY OF GÖTTINGEN   (Germany)

^g UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^h UNIVERSITY OF GOTHENBURG   (Sweden)

ⁱ UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^j NONE   (Germany)

more..

Author keywords

Bisoprolol; Carvedilol; Chronic heart failure; Head to head; Tolerance

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIARRHYTHMIC AGENT; BISOPROLOL; CALCIUM CHANNEL BLOCKING AGENT; CARVEDILOL; CLONIDINE; ERGOTAMINE DERIVATIVE; INOTROPIC AGENT; MONOAMINE OXIDASE INHIBITOR; RIFAMPICIN;

ADULT; AGED; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG CONTRAINDICATION; DRUG DOSE TITRATION; DRUG TOLERABILITY; ELDERLY CARE; HEART FAILURE; HEART HEMODYNAMICS; HUMAN; LABORATORY TEST; MULTICENTER STUDY; PHASE 3 CLINICAL TRIAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RECOMMENDED DRUG DOSE; REVIEW; TREATMENT CONTRAINDICATION; TREATMENT FAILURE; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ADRENERGIC BETA-ANTAGONISTS; AGE DISTRIBUTION; AGED; BISOPROLOL; CARBAZOLES; DOUBLE-BLIND METHOD; DRUG TOLERANCE; FEMALE; HEART FAILURE; HUMANS; MALE; PROPANOLAMINES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; TREATMENT OUTCOME;

EID: 51349165676     PISSN: 18610684     EISSN: 18610692     Source Type: Journal    
DOI: 10.1007/s00392-008-0681-6     Document Type: Review

References (29)

1. A Ahmed MW Rich JL Fleg MR Zile JB Young DW Kitzman TE Love WS Aronow KF Adams M Gheorghiade 2006 Effects of digoxin on morbidity and mortality in diastolic heart failure Circulation 114 397 403
2. AJ Baxter A Spensley A Hildreth G Karimova JE O'Connell CS Gray 2002 Beta-blockers in older persons with heart failure: tolerance and impact on quality of life Heart 88 611 614
3. M Böhm N Werner M Kindermann 2006 Drug treatment of chronic heart failure Clin Res Cardiol 95 36 54
4. F Bursi SA Weston MM Redfield SJ Jacobsen S Pakhomov VT Nkomo RA Meverden VL Roger 2006 Systolic and diastolic heart failure in the community JAMA 296 2209 2216
5. CIBIS-II Investigators and Committees 1999 The cardiac insufficiency bisoprolol study II (CIBIS-II): a randomised trial Lancet 353 9 13
6. JG Cleland A Charlesworth J Lubsen K Swedberg WJ Remme L Erhardt A Di Lenarda M Komajda M Metra C Torp-Pedersen PA Poole-Wilson COMET Investigators 2006 A comparison of the effects of carvedilol and metoprolol on well-being, morbidity, and mortality (the "patient journey") in patients with heart failure: a report from the carvedilol or metoprolol european trial (COMET) J Am Coll Cardiol 47 1603 1611
7. JG Cleland A Cohen-Solal CJ Aguilar R Dietz J Eastaugh F Follath N Freemantle A Gavazzi WH van Gilst FDR Hobbs J Korewicki HC Madeira I Preda K Swedberg J Widimsky 2002 Management of heart failure in primary care (the IMPROVEMENT of heart failure programme): an international survey Lancet 360 1631 1639
8. D Dobre DJ van Veldhuisen G Mordenti M Vintila FM Haaijer-Ruskamp AJ Coats PA Poole-Wilson MD Flather SENIORS Investigators 2007 Tolerance and dose-related effects of nebivolol in elderly patients with heart failure: data from the study of the effects of nebivolol intervention on outcomes and rehospitalisation in seniors with heart failure (SENIORS) trial Am Heart J 154 109 115
9. BR Dulin SJ Haas WT Abraham H Krum 2005 Do elderly systolic heart failure patients benefit from Beta-blockers to the same extent as the non-elderly? Meta-analysis of >12,000 patients in large-scale clinical trials Am J Cardiol 95 896 898
10. MD Flather MC Shibata AJ Coats DJ Van Veldhuisen A Parkhomenko J Borbola A Cohen-Solal D Dumitrascu R Ferrari P Lechat J Soler-Soler L Tavazzi L Spinarova J Toman M Böhm SD Anker SG Thompson PA Poole-Wilson SENIORS Investigators 2005 Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS) Eur Heart J 26 215 225
11. M Hori A Kitabatake H Tsutsui H Okamoto K Shirato R Nagai T Izumi H Yokoyama Y Yasumura Y Ishida M Matsuzaki T Oki M; J-DHF Sekiya The Program Committee 2005 Rationale and design of a randomized trial to assess the effects of beta-blocker in diastolic heart failure; Japanese diastolic heart failure study (J-DHF) J Card Fail 11 542 547
12. WB Kannel 1987 Epidemiology and prevention of cardiac failure: Framingham study insights Eur Heart J 8 Suppl F 23 26
13. M Komajda F Follath K Swedberg J Cleland JC Aguilar A Cohen-Solal R Dietz A Gavazzi WH Van Gilst R Hobbs J Korewicki HC Madeira VS Moiseyev I Preda J Widimsky N Freemantle J Eastaugh J Mason Study Group on Diagnosis of the Working Group on Heart Failure of the European Society of Cardiology 2003 The Euroheart failure survey programme-a survey on the quality of care among patients with heart failure in Europe. Part 2: treatment Eur Heart J 24 464 474
14. H Krum J Hill F Fruhwald C Sharpe G Abraham JR Zhu C Poy JA Kragten 2006 Tolerance of beta-blockers in elderly patients with chronic heart failure: the COLA II study Eur J Heart Fail 8 302 307
15. M Lainščak C Moullet N Schoen M Tendera 2007 Treatment of chronic heart failure with carvedilol in daily practice: the SATELLITE survey experience Int J Cardiol 122 149 155
16. C Maack S Tyroller P Schnabel B Cremers E Dabew M Südkamp M Böhm 2001 Characterization of beta(1)-selectivity, adrenoceptor-G(s)- protein interaction and inverse agonism of nebivolol in human myocardium Br J Pharmacol 132 1817 1826
17. MERIT-HF Study Group 1999 Effect of metoprolol CR/XL in chronic heart failure: metoprolol CR/XL randomised intervention trial in congestive heart failure (MERIT-HF) Lancet 353 2001 2007
18. M Packer 2003 Do beta-blockers prolong survival in heart failure only by inhibiting the beta1-receptor? A perspective on the results of the COMET trial J Card Fail 9 429 443
19. M Packer MB Fowler EB Roecker AJ Coats HA Katus H Krum P Mohacsi JL Rouleau M Tendera C Staiger TL Holcslaw I Amann-Zalan DL DeMets 2002 Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study Circulation 106 2194 2199
20. F Peters-Klimm T Müller-Tasch D Schellberg A Remmpis A Barth N Holzapfel J Jünger W Herzog J Szecsenyi 2008 Guideline adherence for pharmacotherapy of chronic systolic heart failure in general practice: a close look on evidence-based therapy Clin Res Cardiol 97 244 252
21. MA Pfeffer K Swedberg CB Granger P Held JJ McMurray EL Michelson B Olofsson J Ostergren S Yusuf S; Pocock CHARM Investigators, Committees 2003 Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-overall programme Lancet 362 759 766
22. PA Poole-Wilson K Swedberg JG Cleland A Di Lenarda P Hanrath M Komajda J Lubsen B Lutiger M Metra WJ Remme C Torp-Pedersen A Scherhag A Skene 2003 Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the carvedilol or metoprolol european trial (COMET): randomised controlled trial Lancet 362 7 13
23. MC Shibata MD Flather D Wang 2001 Systematic review of the impact of beta-blockers on mortality and hospital admissions in heart failure Eur J Heart Fail 3 351 357
24. MC Shibata CM Soneff RT Tsuyuki 2005 Utilization of evidence-based therapies for heart failure in the institutionalized elderly Eur J Heart Fail 7 1122 1125
25. S Stewart K MacIntyre DJ Hole S Capewell JJV McMurray 2001 More 'malignant' than cancer? Five-year survival following a first admission for heart failure Eur J Heart Fail 3 315 322
26. K Swedberg J Cleland H Dargie H Drexler F Follath M Komajda L Tavazzi OA Smiseth A Gavazzi A Haverich A Hoes T Jaarsma J Korewicki S Lévy C Linde JL Lopez-Sendon MS Nieminen L Piérard WJ Remme 2005 Task force for the diagnosis and treatment of chronic heart failure of the European Society of Cardiology. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005) Eur Heart J 26 1115 1140
27. S Varney 2001 A cost-effectiveness analysis of bisoprolol for heart failure Eur J Heart Fail 3 365 371
28. F Waagstein A Hjalmarson E Varnauskas I Wallentin 1975 Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy Br Heart J 37 1022 1036
29. R Willenheimer DJ van Veldhuisen B Silke E Erdmann F Follath H Krum P Ponikowski A Skene L van de Ven P Verkenne P Lechat CIBIS III Investigators 2005 Effect on survival and hospitalization of initiating treatment for chronic heart failure with bisoprolol followed by enalapril, as compared with the opposite sequence: results of the randomized cardiac insufficiency bisoprolol study (CIBIS) III Circulation 112 2426 2435