The Associations among GNB3 C825T Polymorphism, erectile dysfunction, and related risk factors

Journal of Sexual Medicine

Volumn 5, Issue 9, 2008, Pages 2061-2068

  Lee, Yung Chin ^a   Lin, Hui Hui ^b   Wang, Chii Jye ^a   Liu, Chia Chu ^a   Wu, Wen Jeng ^a   Huang, Chun Hsiung ^a   Chang, Lin Li ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Erectile Dysfunction; GNB3; Polymorphism

Indexed keywords

CHOLESTEROL; CYTOSINE; GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; LIPID; TESTOSTERONE; TRIACYLGLYCEROL; TYROSINE;

ADULT; AGE; ALCOHOL CONSUMPTION; ALLELE; ANAMNESIS; ARTICLE; BODY MASS; CIGARETTE SMOKING; CONTROLLED STUDY; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DISEASE SEVERITY; DNA EXTRACTION; ERECTILE DYSFUNCTION; GENE AMPLIFICATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PENIS ERECTION; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; RISK FACTOR; SCORING SYSTEM; SYSTOLIC BLOOD PRESSURE; TAIWAN; VASCULAR DISEASE;

EID: 51349139203     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2008.00938.x     Document Type: Article

References (39)

1. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol 1994;151:54-61.
2. Laumann EO, West S, Glasser D, Carson C, Rosen R, Kang JH. Prevalence and correlates of erectile dysfunction by race and ethnicity among men aged 40 or older in the United States: From the male attitudes regarding sexual health survey. J Sex Med 2007;4:57-65.
3. Shabsigh R, Anastasiadis AG. Erectile dysfunction. Annu Rev Med 2003;54:153-68.
4. Jackson G. Erectile dysfunction: A marker of silent coronary artery disease. Eur Heart J 2006;27:2613-4.
5. El-Sakka A, Morsy A, Fagih B. Enhanced external counterpulsation in patients with coronary artery disease-associated erectile dysfunction. Part I: Effects of risk factors. J Sex Med 2007;4:771-9.
6. Heruti RJ, Uri I, Arbel Y, Swartzon M, Galor S, Justo D. Erectile dysfunction severity might be associated with poor cardiovascular prognosis in diabetic men. J Sex Med 2007;4:465-71.
7. Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F, Soubrier F. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 1992;51:197-205.
8. Wattanapitayakul SK, Mihm MJ, Young AP, Bauer JA. Therapeutic implications of human endothelial nitric oxide synthase gene polymorphism. Trends Pharmacol Sci 2001;22:361-8.
9. El-Sakka AI. Association of risk factors and medical comorbidities with male sexual dysfunctions. J Sex Med 2007;4:1691-700.
10. Siffert W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R, Sharma AM, Ritz E, Wichmann HE, Jakobs KH, Horsthemke B. Association of a human G-protein beta3 subunit variant with hypertension. Nat Genet 1998;18:45-8.
11. Kedzierska K, Ciechanowski K, Safranow K, Bober J, Golembiewska E, Kwiatkowska E, Kabat-Koperska J, Ostrowski M, Adler G, Chlubek D. GNB3 C825T and ACE I/D polymorphisms on the sodium-proton exchanger and the prevalence of essential hypertension in males. Arch Med Res 2006;37:150-7.
12. Sperling H, Eisenhardt A, Virchow S, Hauck E, Lenk S, Porst H, Stief C, Wetterauer U, Rubben H, Muller N, Siffert W. Sildenafil response is influenced by the G protein beta 3 subunit GNB3 C825T polymorphism: A pilot study. J Urol 2003;169:1048-51.
13. Kiani JG, Saeed M, Parvez SH, Frossard PM. Association of G-protein beta-3 subunit gene (GNB3) T825 allele with Type II diabetes. Neuro Endocrinol Lett 2005;26:87-8.
14. Renner W, Hoffmann MM, Grünbacher G, Winkelmann BR, Boehm BO, März W. G-protein beta3 subunit (GNB3) gene polymorphisms and cardiovascular disease: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Atherosclerosis 2007;192:108-12.
15. Lue TF. Erectile dysfunction. N Engl J Med 2000;342:1802-13.
16. Terai A, Ichioka K, Matsui Y, Yoshimura K. Association of lower urinary tract symptoms with erectile dysfunction in Japanese men. Urology 2004;64:132-6.
17. Lee YC, Huang CH, Wang CJ, Liu CC, Wu WJ, Chang LL, Lin HH. The associations among eNOS G894T gene polymorphism, erectile dysfunction and related risk factors. BJU Int 2007;100:1116-20.
18. Ponholzer A, Temml C, Rauchenwald M, Madersbacher S. Vascular risk factors and erectile dysfunction in a cohort of healthy men. Int J Impot Res 2006;18:489-93.
19. Zhu H, Wang X, Lu Y, Poola J, Momin Z, Harshfield GA, Snieder H, Dong Y. Update on G-protein polymorphisms in hypertension. Curr Hypertens Rep 2006;8:23-9.
20. Benjafield AV, Jeyasingam CL, Nyholt DR, Griffiths LR, Morris BJ. G-protein beta3 subunit gene (GNB3) variant in causation of essential hypertension. Hypertension 1998;32:1094-7.
21. Ishikawa K, Imai Y, Katsuya T, Ohkubo T, Tsuji I, Nagai K, Takami S, Nakata Y, Satoh H, Hisamichi S, Higaki J, Ogihara T. Human G-protein beta3 subunit variant is associated with serum potassium and total cholesterol levels but not with blood pressure. Am J Hypertens 2000;13:140-5.
22. Huang X, Ju Z, Song Y, Zhang H, Sun K, Lu H, Yang Z, Jose PA, Zhou G, Wang M, Wang W, Feng S, Hui R. Lack of association between the G protein beta3 subunit gene and essential hypertension in Chinese: A case-control and a family-based study. J Mol Med 2003;81:729-35.
23. Yamamoto M, Abe M, Jin JJ, Wu Z, Tabara Y, Mogi M, Kohara K, Miki T, Nakura J. Association of GNB3 gene with pulse pressure and clustering of risk factors for cardiovascular disease in Japanese. Biochem Biophys Res Commun 2004;316:744-8.
24. Chen YY, Li GW, Li CM, Huang XH, Ju ZY, Sun SX, Cai H, Hui RT. Association between G-protein beta3 subunit (GNB(3)) gene C825T polymorphism, hypertension, insulin resistance and obesity. Zhonghua Yi Xue Za Zhi 2003;83:1229-32.
25. Siffert W, Forster P, Jöckel KH, Mvere DA, Brinkmann B, Naber C, Crookes R, Du P Heyns A, Epplen JT, Fridey J, Freedman BI, Müller N, Stolke D, Sharma AM, Al Moutaery K, Grosse-Wilde H, Buerbaum B, Ehrlich T, Ahmad HR, Horsthemke B, Du Toit ED, Tiilikainen A, Ge J, Wang Y, Rosskopf D. Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol 1999;10:1921-30.
26. Feldman RD, Hegele RA. G-protein polymorphisms and maternal/neonatal metabolism: Still a weight for the answer. Lancet 2000;355:1201-2.
27. Hauner H, Röhrig K, Siffert W. Effects of the G-protein beta3 subunit 825T allele on adipogenesis and lipolysis in cultured human preadipocytes and adipocytes. Horm Metab Res 2002;34:475-80.
28. Andersen G, Overgaard J, Albrechtsen A, Glümer C, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O. Studies of the association of the GNB3 825C>T polymorphism with components of the metabolic syndrome in white Danes. Diabetologia 2006;49:75-82.
29. Wingard C, Fulton D, Husain S. Altered penile vascular reactivity and erection in the Zucker obese-diabetic rat. J Sex Med 2007;4:348-62.
30. Fernández-Real JM, Peñarroja G, Richart C, Castro A, Vendrell J, Broch M, López-Bermejo A, Ricart W. G protein beta3 gene variant, vascular function, and insulin sensitivity in type 2 diabetes. Hypertension 2003; 41: 124-9.
31. Kato N, Sugiyama T, Morita H, Kurihara H, Yamori Y, Yazaki Y. G protein beta3 subunit variant and essential hypertension in Japanese. Hypertension 1998; 32: 935-8.
32. Dzida G, Golon-Siekierska P, Puzniak A, Sobstyl J, Bilan A, Mosiewicz J, Hanzlik J. G-protein beta3 subunit gene C825T polymorphism is associated with arterial hypertension in Polish patients with type 2 diabetes mellitus. Med Sci Monit 2002; 8: 597-602.
33. Zill P, Baghai TC, Zwanzger P, Schüle C, Minov C, Riedel M, Neumeier K, Rupprecht R, Bondy B. Evidence for an association between a G-protein beta3-gene variant with depression and response to antidepressant treatment. Neuroreport 2000; 11: 1893-7.
34. Lee HJ, Cha JH, Ham BJ, Han CS, Kim YK, Lee SH, Ryu SH, Kang RH, Choi MJ, Lee MS. Association between a G-protein beta 3 subunit gene polymorphism and the symptomatology and treatment responses of major depressive disorders. Pharmacogenomics J 2004; 4: 29-33.
35. Kang RH, Hahn SW, Choi MJ, Lee MS. Relationship between G-protein beta-3 subunit C825T polymorphism and mirtazapine responses in Korean patients with major depression. Neuropsychobiology 2007; 56: 1-5.
36. Xie D, Odronic SI, Wu F, Pippen AM, Donatucci CF, Annex BH. A mouse model of hypercholesterolemia-induced erectile dysfunction. J Sex Med 2007; 4: 898-907.
37. Mulhall J, Teloken P, Brock G, Kim E. Obesity, dyslipidemias and erectile dysfunction: A report of a subcommittee of the sexual medicine society of North America. J Sex Med 2006; 3: 778-86.
38. Eisenhardt A, Siffert W. Genetic risk factors for erectile dysfunction and genetic determinants of drug response-on the way to improve drug safety? Herz 2003; 28: 304-13.
39. Bae Y, Park C, Han J, Hong YJ, Song HH, Shin ES, Lee JE, Han BG, Jang Y, Shin DJ, Yoon SK. Interaction between GNB3 C825T and ACE I/D polymorphisms in essential hypertension in Koreans. J Hum Hypertens 2007; 21: 159-66.