Presence of gas in the refluxate enhances reflux perception in non-erosive patients with physiological acid exposure of the oesophagus

Gut

Volumn 57, Issue 4, 2008, Pages 443-447

  Emerenziani, S ^a   Sifrim, D ^b   Habib, F I ^c   Ribolsi, M ^a   Guarino, M P L ^a   Rizzi, M ^a   Caviglia, R ^a   Petitti, T ^a   Cicala, M ^a,d  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d NONE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PROTON PUMP INHIBITOR;

ACIDITY; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ESOPHAGOSCOPY; ESOPHAGUS; ESOPHAGUS MANOMETRY; ESOPHAGUS PH; FEMALE; GAS; GASTRIC PH MONITORING; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMAN; LIQUID; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NON EROSIVE REFLUX DISEASE; PRIORITY JOURNAL; REFLUX ESOPHAGITIS; STATISTICAL SIGNIFICANCE; STOMACH ACID; STOMACH CONTENT; TREATMENT DURATION; TREATMENT OUTCOME; AMBULATORY MONITORING; CHEMISTRY; IMPEDANCE; METABOLISM; METHODOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; PH; SENSORY DYSFUNCTION; STOMACH JUICE;

ADULT; ELECTRIC IMPEDANCE; ESOPHAGUS; FEMALE; GASES; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL CONTENTS; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MIDDLE AGED; MONITORING, AMBULATORY; PROTON PUMP INHIBITORS; SENSATION DISORDERS;

EID: 41149095043     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2007.130104     Document Type: Article

References (32)

1. Quigley EMM, DiBaise JK. Non-erosive reflux disease: the real problem in gastro-oesophageal reflux disease. Digest Liver Dis 2001;33:523-7.
2. Fass R, Fennerty B, Vakil N. Non-erosive reflux disease: current concepts and dilemmas. Am J Gastroenterol 2001;96:303-14.
3. Clouse RE, Richter JE, Heading RC, et al. Functional gastrointestinal disorders. Gut 1999;24(Suppl II):1-6.
4. Tew S, Jamieson GG, Pilowsky I, et al. The illness behavior of patients with gastroesophageal reflux disease with and without endoscopic esophagitis. Dis Esophagus 1997;10:9-15.
5. Lind T, Havelund T, Carlsson R, et al. Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response. Scand J Gastroenterol 1997;32:974-9.
6. Richter JE, Kovacs TO, Greski-Rose PA, et al. Lansoprazole in the treatment of heartburn in patients without erosive oesophagitis. Aliment Pharmacol Ther 1999;13:795-804.
7. Rodriguez-Stanley S, Robinson M, Earnest DL, et al. Esophageal hypersensitivity may be a major cause of heartburn. Am J Gastroenterol 1999;94:628-31.
8. Trimble KC, Pryde A, Heading RC. Lowered oesophageal sensory thresholds in patients with symptomatic but not excess gastro-oesophageal reflux: evidence for a spectrum of visceral sensitivity in GORD. Gut 1995;37:7-12.
9. Fass R, Tougas G. Functional heartburn: the stimulus, the pain, and the brain. Gut 2002;51:885-92.
10. Sifrim D, Dupont L, Blondeau K, et al. Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring. Gut 2005;54:449-54.
11. Zerbib F, Roman S, Ropert A, et al. Esophageal pH-monitoring and symptom analysis in GERD: a study in patients off and on therapy. Am J Gastroenterol 2006;101:1956-63.
12. Cicala M, Emerenziani S, Caviglia R, et al. Intra-oesophageal distribution and perception of acid reflux in non-erosive gastro-oesophageal reflux disease patients. Aliment Pharmacol Ther 2003;18:605-13.
13. Mehta AJ, De Caestecker JS, Camm AJ, et al. Sensitization to painful distention and abnormal sensory perception in the esophagus. Gastroenterology 1995;108:311-9.
14. Fass R, Naliboff B, Higa L, et al. Differential effect of long-term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 1998;115:1363-73.
15. Hu W, Martin C, Talley J. Intraesophageal acid perfusion sensitizes the esophagus to mechanical distension: a barostat study. Am J Gastroenterol 2000;95:2189-94.
16. Takeda T, Nabae T, Kassab G, et al. Oesophageal wall stretch: the stimulus for distension induced oesophageal sensation. Neurogastroenterol Motility 2004;16:721-8.
17. Orr W, Elsenbruch S, Harnish M, et al. Proximal migration of esophageal acid perfusions during waking and sleep. Am J Gastroenterol 2000;95:37-42.
18. Emerenziani S, Zhang X, Blondeau K, et al. Gastric fullness, physical activity, and proximal exent of gastroesophageal reflux. Am J Gastroenterol 2005;100:1251-6.
19. Silny J. Intraluminal multiple electrical impedance procedure for measurement of gastrointestinal motility. J Gastrointest Mot 1991;3:151-62.
20. Bredenoord AJ, Weusten BL, Timmer R, et al. Reproducibility of multichannel intraluminal electrical impedance monitoring of gastroesophageal reflux. Am J Gastroenterol 2005;100:265-9.
21. Sifrim D, Castell D, Dent J, et al. Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux. Gut 2004;53:1024-31.
22. Weusten BL, Roelofs JM, Akkermans LM, et al. The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data. Gastroenterology 1994;107:1741-5.
23. Hosmer DW, Lemeshow S. In: Applied logistic regression, 2nd edition. New York: Wiley-Interscience Publications, 2000.
24. Sifrim D, Holloway R, Silny J, et al. Acid, non-acid, and gas reflux in patients with gastroesophageal reflux during ambulatory 24-hour pH-impedance recordings. Gastroenterology 2001;120:1588-98.
25. Bredenoord AJ, Weusten BL, Curvers WL, et al. Determinants of perception of heartburn and regurgitation. Gut 2005;55:313-8.
26. Bredenoord AJ, Weusten BL, Timmer R, et al. Addition of esophageal impedance monitoring to pH monitoring increases the yield of symptom association analysis in patients off PPI therapy. Am J Gastroenterol 2006;101:453-59.
27. Galmiche JP, Clouse R, Balint A, et al. Functional esophageal disorders. Gastroenterology 2006;130:1459-165.
28. Taghavi SA, Ghasedi M, Saperi-Firoozi M, et al. Symptom association probability and symptom sensitivity index: preferable but still suboptimal predictors of response to high dose omeprazole. Gut 2005;54:1067-71.
29. Peghini PL, Johnston BT, Leite LP, et al. Mucosal acid exposure sensitized a subset of normal subjects to intra-esophageal balloon distension. Eur J Gastroenterol Hepatol 1996;8:979-83.
30. DeVault KR. Acid infusion does not affect intraesophageal balloon distention-induced sensory and pain thresholds. Am J Gastroenterol 1997;92:947-9.
31. Quigley EMM. Motility, heartburn and dyspepsia. Aliment Pharmacol Ther 1997;11(Suppl.2):41-50.
32. Carlsson R, Dent J, Bolling-.Sternevald E, et al. The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal disease. Scand J Gastroenterol 1998;33:1023-9.