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Volumn 47, Issue 3-4, 2007, Pages 385-396

The theoretical challenge posed by low-voltage membrane electroporation, viewed from the perspective of continuum and molecular-level models

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EID: 51249111992     PISSN: 00212148     EISSN: None     Source Type: Journal    
DOI: 10.1560/IJC.47.3-4.385     Document Type: Conference Paper
Times cited : (4)

References (48)
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    • Zimmerman, U.; Neil, G., Eds. Electromanipulation of Cells; CRC Press: New York, 1996.
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    • Tarek, M. Biophys. J. 2005, 88, 4045-4053.
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    • Tarek, M.1
  • 16
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    • Kandasamya, S.K.; Larson, R.G. J. Chem. Phys. 2006, 125, 0749011-0749019.
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  • 25
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    • An alternate description of short λ dispersion was suggested in ref 23 based on MD analysis of membrane fluctuations; it takes the form of a surface tension contribution fsq, γ q2
    • 2.
  • 36
    • 51249109834 scopus 로고    scopus 로고
    • The lowest electroporation voltage observed in the MD simulation of DMPC14 is ∼2 V, which is significantly lower than the Crowley limit (∼2.85 V) and still exceeds our estimate, Vcr ∼ 1.6 V. The corresponding time of the pore formation is ∼5 nanoseconds. In the most recent MD study of POPC16 the electroporation was observed at V ∼1.75 V, with the pore formation time ∼30 ns. It is instructive to reflect on the apparently counterintuitive relation between these two estimates of the breakdown voltage, which corresponds to the same charge disbalance of Δq, 5e across the DMPC14 and POPC 16 bilayers. With ∼7% difference in the area A per lipid (∼0.56 nm2 for DMPC and ∼0.60 nm2 POPC, the same number of lipids (sixty-four) per simulated leaflet and with hydrophobic domain (d) of POPC being ∼10% thicker, the potential across POPC bilayer
    • 16 or refs 12-14 should predict higher compressibility of the simulated bilayers. It is appropriate to ask if the comparatively low voltage of electroporation observed in ref 16 is a result of the aforementioned "softness" of the simulated bilayer.
  • 42
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    • Partenskii, M.; Jordan, P. ArXiv. Physics 2005, 0412183, 23 pages.
    • Partenskii, M.; Jordan, P. ArXiv. Physics 2005, 0412183, 23 pages.
  • 45
    • 51249094825 scopus 로고    scopus 로고
    • Importantly, an applied field can also trigger phase separation in membranes composed of lipids of different chain lengths,44 which can influence electroporation as well
    • 44 which can influence electroporation as well.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.