Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice

Immunogenetics

Volumn 60, Issue 10, 2008, Pages 599-607

  Zhang, Ming Cai ^a,b   Furukawa, Hiroshi ^a,c   Tokunaka, Kazuhiro ^d   Saiga, Kan ^d   Date, Fumiko ^a   Owada, Yuji ^e   Nose, Masato ^f   Ono, Masao ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c SAGAMIHARA NATIONAL HOSPITAL   (Japan)

^d NIPPON KAYAKU CO LTD   (Japan)

^e YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Desmoglein 4; Early transposon; Hypotrichosis; Lupus prone mouse; Mast cell

Indexed keywords

DESMOGLEIN; DESMOGLEIN 4; GENOMIC DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL HYPERPLASIA; CELL POPULATION; CONTROLLED STUDY; DNA SEQUENCE; EXON; FEMALE; GENE INSERTION; GENE MUTATION; HAIR FOLLICLE; HYPOTRICHOSIS; INTRON; LUPUS ERYTHEMATOSUS NEPHRITIS; MALE; MAST CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPLEEN CELL; SURVIVAL TIME; T LYMPHOCYTE; TRANSPOSON;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; DESMOGLEINS; FLOW CYTOMETRY; GENETIC PREDISPOSITION TO DISEASE; HAIR FOLLICLE; HYPERPLASIA; HYPOTRICHOSIS; INTRONS; LUPUS VULGARIS; MAST CELLS; MICE; MICE, INBRED MRL LPR; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; MUTATION; SEQUENCE HOMOLOGY, AMINO ACID; SKIN; SURVIVAL RATE;

MUS;

EID: 51249106658     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00251-008-0320-4     Document Type: Article

References (27)

1. SN Abraham R Malaviya 1997 Mast cells in infection and immunity Infect Immun 65 3501 3508
2. M Adachi R Watanabe-Fukunaga S Nagata 1993 Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice Proc Natl Acad Sci U S A 90 1756 1760 doi:10.1073/pnas.90.5.1756
3. PC Arck B Handjiski EM Peters AS Peter E Hagen A Fischer 2003 Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways Am J Pathol 162 803 814
4. C Baust GJ Baillie DL Mager 2002 Insertional polymorphisms of ETn retrotransposons include a disruption of the wiz gene in C57BL/6 mice Mamm Genome 13 423 428 doi:10.1007/s00335-002-2178-3
5. C Baust L Gagnier GJ Baillie MJ Harris DM Juriloff DL Mager 2003 Structure and expression of mobile ETnII retroelements and their coding-competent MusD relatives in the mouse insertional polymorphisms of ETn retrotransposons include a disruption of the wiz gene in C57BL/6 mice J Virol 77 11448 11458 doi:10.1128/JVI.77.21.11448-11458.2003
6. H Bazzi A Martinez-Mir A Kljuic AM Christiano 2005 Desmoglein 4 mutations underlie localized autosomal recessive hypotrichosis in humans, mice, and rats J Investig Dermatol Symp Proc 10 222 224 doi:10.1111/j.1087-0024.2005.10110.x
7. SC Bischoff G Sellge 2002 Mast cell hyperplasia: role of cytokines Int Arch Allergy Immunol 127 118 122 doi:10.1159/000048181
8. F Fagotto BM Gumbiner 1996 Cell contact-dependent signaling Dev Biol 180 445 454 doi:10.1006/dbio.1996.0318
9. D Garrod M Chidgey 2007 Desmosome structure, composition and function Biochim Biophys Acta 9 9
10. M Hofmann M Harris D Juriloff T Boehm 1998 Spontaneous mutations in SELH/Bc mice due to insertions of early transposons: molecular characterization of null alleles at the nude and albino loci Genomics 52 107 109 doi:10.1006/geno.1998.5409
11. S Honda K Nemoto T Mae K Kinjoh M Kyogoku H Kawamura 1999 Mice with early onset of death (EOD) due to lupus glomerulonephritis Clin Exp Immunol 116 153 163 doi:10.1046/j.1365-2249.1999.00847.x
12. JF Huntley GF Newlands S Gibson A Ferguson HR Miller 1985 Histochemical demonstration of chymotrypsin like serine esterases in mucosal mast cells in four species including man J Clin Pathol 38 375 384 doi:10.1136/jcp.38.4.375
13. CA Jahoda A Kljuic R O'Shaughnessy N Crossley CJ Whitehouse M Robinson 2004 The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene Genomics 83 747 756 doi:10.1016/j.ygeno.2003.11.015
14. A Kljuic H Bazzi JP Sundberg A Martinez-Mir R O'Shaughnessy MG Mahoney 2003 Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris Cell 113 249 260 doi:10.1016/S0092-8674(03)00273-3
15. H Komori H Furukawa S Mori MR Ito M Terada MC Zhang 2006 A signal adaptor SLAM-associated protein regulates spontaneous autoimmunity and Fas-dependent lymphoproliferation in MRL-Faslpr lupus mice J Immunol 176 395 400
16. T Kumamoto D Shalhevet H Matsue ME Mummert BR Ward JV Jester 2003 Hair follicles serve as local reservoirs of skin mast cell precursors Blood 102 1654 1660 doi:10.1182/blood-2003-02-0449
17. LF Lu EF Lind DC Gondek KA Bennett MW Gleeson K Pino-Lagos 2006 Mast cells are essential intermediaries in regulatory T-cell tolerance Nature 442 997 1002 doi:10.1038/nature05010
18. JA McGrath V Wessagowit 2005 Human hair abnormalities resulting from inherited desmosome gene mutations Keio J Med 54 72 79 doi:10.2302/kjm.54.72
19. AG Messenger H Bazzi R Parslew L Shapiro AM Christiano 2005 A missense mutation in the cadherin interaction site of the desmoglein 4 gene underlies localized autosomal recessive hypotrichosis J Invest Dermatol 125 1077 1079 doi:10.1111/j.0022-202X.2005.23903.x
20. B Meyer H Bazzi V Zidek A Musilova M Pravenec TW Kurtz 2004 A spontaneous mutation in the desmoglein 4 gene underlies hypotrichosis in a new lanceolate hair rat model Differentiation 72 541 547 doi:10.1111/j.1432-0436.2004.07209007. x
21. C Noli A Miolo 2001 The mast cell in wound healing Vet Dermatol 12 303 313 doi:10.1046/j.0959-4493.2001.00272.x
22. P Pisitkun JA Deane MJ Difilippantonio T Tarasenko AB Satterthwaite S Bolland 2006 Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication Science 312 1669 1672 doi:10.1126/science.1124978
23. J Schweizer 2006 More than one gene involved in monilethrix: intracellular but also extracellular players J Invest Dermatol 126 1216 1219 doi:10.1038/sj.jid.5700266
24. HW Wang N Tedla JE Hunt D Wakefield HP McNeil 2005 Mast cell accumulation and cytokine expression in the tight skin mouse model of scleroderma Exp Dermatol 14 295 302 doi:10.1111/j.0906-6705.2005.00315.x
25. K Weller K Foitzik R Paus W Syska M Maurer 2006 Mast cells are required for normal healing of skin wounds in mice FASEB J 20 2366 2368 doi:10.1096/fj.06-5837fje
26. NV Whittock 2003 Genomic sequence analysis of the mouse desmoglein cluster reveals evidence for six distinct genes: characterization of mouse DSG4, DSG5, and DSG6 J Invest Dermatol 120 970 980 doi:10.1046/j.1523-1747.2003. 12257.x
27. M Yoshida K Saiga T Hato S Iwaki T Niiya N Arita 2006 Cappuccino mutation in an autoimmune-prone strain of mice suggests a role of platelet function in the progression of immune complex crescentic glomerulonephritis Arthritis Rheum 54 2934 2943 doi:10.1002/art.22059