High-dose methylprednisolone in a pregnant woman with Crohn's disease and adrenal suppression in her newborn

Neonatology

Volumn 94, Issue 4, 2008, Pages 306-309

  Homar, Vesna ^a   Grosek, Stefan ^a   Battelino, Tadej ^b  

^a UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^b UNIVERSITY CHILDREN S HOSPITAL   (Slovenia)

Author keywords

Adrenal insufficiency, newborn; Crohn's disease; Methylprednisolone therapy, Crohn's disease; Pregnancy, Crohn's disease

Indexed keywords

HYDROCORTISONE; HYDROCORTISONE ACETATE; METHYLPREDNISOLONE;

ADRENAL INSUFFICIENCY; ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; CONTINUOUS INFUSION; CORTICOSTEROID THERAPY; CORTICOTROPIN TEST; CROHN DISEASE; DRUG MEGADOSE; EVENING DOSAGE; FEMALE; HUMAN; MALE; MORNING DOSAGE; NEONATAL RESPIRATORY DISTRESS SYNDROME; NEWBORN; NEWBORN DISEASE; NEWBORN INTENSIVE CARE; PREGNANT WOMAN; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADRENAL INSUFFICIENCY; ADULT; CROHN DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; HYDROCORTISONE; INFANT, NEWBORN; MALE; METHYLPREDNISOLONE; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 51249087068     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000151652     Document Type: Article

References (26)

1. Kane S: Inflammatory bowel disease in pregnancy. Gastroenterol Clin North Am 2003;32:323-340.
2. Friedman S, Regueiro MD: Pregnancy and nursing in inflammatory bowel disease. Gastroenterol Clin North Am 2002;31:265-273.
3. Tromm A, Möllmann H, Barth J, Hochhaus G, Krieg M, Bigalke C, Möllmann A, Derendorf H: Pharmacokinetics and rectal bio-availability of hydrocortisone acetate after single and multiple administration in healthy subjects and patients. J Clin Pharmacol 2001;41:536-541.
4. van Runnard Heimel PJ, Schobben AF, Huisjes AJ, Franx A, Bruinse HW: The transplacental passage of prednisolone in pregnancies complicated by early-onset HELLP syndrome. Placenta 2005;26:842-845.
5. Beitins IZ, Bayard F, Ances IG, Kowarski A, Migeon CJ: The transplacental passage of prednisone and prednisolone in pregnancy near term. J Pediatr 1972;81:936-945.
6. Sun K, Adamson SL, Yang K, Challis JR: Interconversion of cortisol and cortisone by 11beta-hydroxysteroid dehydrogenases type 1 and 2 in the perfused human placenta. Placenta 1999;20:13-19.
7. Fraser FC, Sajoo A: Teratogenic potential of corticosteroids in humans. Teratology 1995;51:45-46.
8. Briggs GG, Freeman RK, Yaffe SJ: Drugs in Pregnancy and Lactation, ed 7. Baltimore, Lippincott Williams & Wilkins, 2005.
9. Mogadam M, Dobbins WO 3rd, Korelitz BI, Ahmed SW: Pregnancy in inflammatory bowel disease: effect of sulfasalazine and corticosteroids on fetal outcome. Gastroenterology 1981;80:72-76.
10. Isarangkura M, Bhongvej S, Bunnag S: Adrenal insufficiency in a newborn infant born to a mother who received corticosteroid throughout pregnancy. Med Assoc Thai 1978;61:647-650.
11. Grajwer LA, Lilien LD, Pildes RS: Neonatal subclinical adrenal insufficiency. Result of maternal steroid therapy. JAMA 1977;238:1279-1280.
12. Kreines K, DeVaux WD: Neonatal adrenal insufficiency associated with maternal Cushing's syndrome. Pediatrics 1971;47:516-519.
13. Oppenheimer EH: Lesions in the adrenals of an infant following maternal corticosteroid therapy. Johns Hopkins Med J 1964;114:146-151.
14. Connell W, Miller A: Treating inflammatory bowel disease during pregnancy: risks and safety of drug therapy. Drug Saf 1999;21:311-323.
15. Limal JM, Bouhours-Nouet N, Rouleau S, Gatelais F, Coutant R: Acute adrenal insufficiency in the newborn. Arch Pédiatr 2006;13:1358-1363.
16. Weintrob N, Drouin J, Vallette-Kasic S, Taub E, Marom D, Lebenthal Y, Klinger G, Bron-Harlev E, Shohat M: Low estriol levels in the maternal triple-marker screen as a predictor of isolated adrenocorticotropic hormone deficiency caused by a new mutation in the TPIT gene. Pediatrics 2006;117:e322-e327.
17. Dominitz JA, Young JC, Boyko EJ: Outcomes of infants born to mothers with inflammatory bowel disease: a population-based cohort study. Am J Gastroenterol 2002;97:641-648.
18. Fonager K, Sørensen HT, Olsen J, Dahlerup JF, Rasmussen SN: Pregnancy outcome for women with Crohn's disease: a follow-up study based on linkage between national registries. Am J Gastroenterol 1998;93:2426-2430.
19. Ludvigsson JF, Ludvigsson J: Inflammatory bowel disease in mother or father and neonatal outcome. Acta Paediatr 2002;91:145-151.
20. Lockshin MD, Sammaritano LR: Corticosteroids in pregnancy. Scand J Rheumatol 1998;27:136-138.
21. Burton PJ, Waddell BJ: Dual function of 11β -hydroxysteroid dehydrogenase in placenta: modulating placental glucocorticoid passage and local steroid action. Biol Reprod 1999;60:234-240.
22. Dodds HM, Taylor PJ, Johnson LP, Mortimer RH, Pond SM, Cannell GR: Cortisol metabolism and its inhibition by glycyrrhetinic acid in the isolated perfused human placental lobule. J Steroid Biochem Mol Biol 1997;62:337-343.
23. Petitjean O, Wendling JL, Tod M, Louchahi K, Nicolas P, Perret G, Astier A: Pharmacokinetics and absolute rectal bioavailability of hydrocortisone acetate in distal colitis. Aliment Pharmacol Ther 1992;6:351-357.
24. Möllmann H, Barth J, Möllmann C, Tunn S, Krieg M, Derendorf H: Pharmacokinetics and rectal bioavailability of hydrocortisone acetate. J Pharm Sci 1991;80:835-836.
25. Langer M, Modi BP, Agus M: Adrenal insufficiency in the critically ill neonate and child. Curr Opin Pediatr 2006;18:448-453.
26. Fernandez E, Schrader R, Watterberg K: Prevalence of low cortisol values in term and near-term infants with vasopressor-resistant hypotension. J Perinatol 2005;25:114-118.